Hypervariable region
Long-Term Evolution of the Hypervariable Region of Hepatitis C Virus in a Common-Source-Infected Cohort
... virus hypervariable region (HVR) and flanking regions of the E1 and E2 envelope proteins have been studied in a cohort of women infected from a common source of anti-D ...this region can evolve in ...
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Sequence evolution of the hypervariable region in the putative envelope region E2/NS1 of hepatitis C virus is correlated with specific humoral immune responses.
... the hypervariable region 1 (HVR1) in the N terminus of E2/NS1 of hepatitis C virus (HCV) was studied retrospectively in six chimpanzees inoculated with the same genotype 1b strain, containing a unique ...
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Isolation And Characterization Of Hypervariable Region (HVR II) From Cellulose Synthase Gene In Neolamarckia Macrophylla
... two hypervariable regions (HVR I and II), several transmembrane domains and conserved residues [1], [7], [8], ...The hypervariable region II (HVRII) is made up of around 500bp to 600bp and the amino ...
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Role of the E2 Hypervariable Region (HVR1) in the Immunogenicity of a Recombinant Hepatitis C Virus Vaccine
... HCV utilizes many strategies to evade humoral control (33). For example, in order to mask the exposure to and efficacy of neutralizing antibodies, the glycoproteins gpE1 and gpE2 are heavily glycosylated (34, 35), and the ...
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Hypervariable Region 1 Sequence Stability during Hepatitis C Virus Replication in Chimpanzees
... The putative envelope 2 (E2) gene of hepatitis C virus (HCV) contains a highly variable region referred to as hypervariable region 1 (HVR1). We hypothesized that this genetic variability is driven by ...
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Vertical Transmission of the Hepatitis C Virus to Infants of Anti Human Immunodeficiency Virus Negative Mothers: Molecular Evolution of Hypervariable Region 1 in Prenatal and Perinatal or Postnatal Infections
... In a prospective study of 33 infants born to hepatitis C virus (HCV)-positive human immunodeficiency virus-negative mothers the vertical transmission of HCV occurred in 6.8%. The evolution of HCV infection in two babies ...
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Evolution of Hypervariable Region 1 of Hepatitis C Virus in Primary Infection
... The hypervariable region 1 (HVR-1) of the putative envelope encoding E2 region of hepatitis C virus (HCV) RNA was analyzed in sequential samples from three patients with acute type C hepatitis ...
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Role of Hypervariable Region 1 for the Interplay of Hepatitis C Virus with Entry Factors and Lipoproteins
... Hepatitis C virus (HCV) particles associate with lipoproteins and infect cells by using at least four cell entry factors. These fac- tors include scavenger receptor class B type I (SR-BI), CD81, claudin 1 (CLDN1), and ...
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A study of mt-dna hypervariable region 1 (HVI) sequence polymorphism on residents of Johor in Malaysia
... D-loop region has confirmed to be a best tool to identify forensic human, particularly for highly degraded samples (Cordner et ...the region including hypervariable region 1 (HV1, ...
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Antibody Response to Hypervariable Region 1 Interferes with Broadly Neutralizing Antibodies to Hepatitis C Virus
... Hypervariable region 1 (HVR1) (amino acids [aa] 384 to 410) on the E2 glycoprotein of hepatitis C virus contributes to persistent infection by evolving escape mutations that attenuate binding of inhibitory ...
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The Hypervariable Region of Meningococcal Major Pilin PilE Controls the Host Cell Response via Antigenic Variation
... -helical region followed by a globular C-terminal domain containing a disulfide bonded region between the two conserved cysteines (D- region) (for review, see reference ...
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Impact of Preservation Method and 16S rRNA Hypervariable Region on Gut Microbiota Profiling
... Since microbiome research is quickly shifting toward determination of small effect size variations relevant to host health, understanding the effects of preservative solutions is crucial to minimize bias. As part of the ...
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Characterization of Hepatitis C Virus genotype 3a Hypervariable region 1 in patients achieved rapid virological response to alpha interferon and Ribavirin Combination therapy
... variable region is quite vari- able region it still maintains its physiochemical properties which help it maintaining its structure ensures its viability and proper ...
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Genetic drift in hypervariable region 1 of the viral genome in persistent hepatitis C virus infection.
... We further investigated the sequence variability of the HCV genomic region that entirely encodes the envelope proteins gp35 and gp7O; these sequences were derived from virus isolated dur[r] ...
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Genetic Heterogeneity of Hypervariable Region 1 of the Hepatitis C Virus (HCV) Genome and Sensitivity of HCV to Alpha Interferon Therapy
... analysis of the nucleotide sequence entropy and genetic distance showed no statistical differences between responders and nonresponders. By contrast, nonsynonymous substitutions were more frequent than synony- mous ...
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Identification of a hypervariable region in the long terminal repeat of equine infectious anemia virus.
... Differences in cytopathogenicity and host cell range among infectious molecular clones of human immunodeficiency virus type 1 Downloaded from http://jvi.asm.org/ on November 10, 2019 by [r] ...
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Improved molecular detection of Babesia infections in animals using a novel quantitative real time PCR diagnostic assay targeting mitochondrial DNA
... Samples of ethylenediamine tetraacetic acid (EDTA)-antic- oagulated whole blood specimens from various host ani- mals submitted to the VBDDL-NCSU for research or diagnostic testing were used to test the sensitivity and ...
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Genetic Diversity and Tissue Compartmentalization of the Hepatitis C Virus Genome in Blood Mononuclear Cells, Liver, and Serum from Chronic Hepatitis C Patients
... a hypervariable region (called HVR1) of 81 nucleotides (nt), located in the 59-terminus region of the envelope glycoprotein 2 (E2) gene, that may account for more than 60% of the amino acid ...
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The susceptibility sequence to rheumatoid arthritis is a cross reactive B cell epitope shared by the Escherichia coli heat shock protein dnaJ and the histocompatibility leukocyte antigen DRB10401 molecule
... third hypervariable region of the human histocompatibility antigen (HLA) DRB10401 (formerly known as HLA Dw4), the part of the molecule that carries susceptibility to rheumatoid ...third ...
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Mitochondrial genetic background in Ghanaian patients with primary open-angle glaucoma
... southern region of Ghana). The hypervariable region-I (HVS-I) and coding regions comprising mtDNA haplogroup diagnostic polymorphisms were polymerase chain reaction (PCR) amplified and sequenced in ...
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