multiple sclerosis lesions
Comparison of MR pulse sequences in the detection of multiple sclerosis lesions
... of multiple sclerosis ...five lesions were seen only by conventional spin-echo and 63 were seen only by fast spin-echo; in comparing conventional spin-echo with fast FLAIR sequences, 18 ...
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The evolution of multiple sclerosis lesions on serial MR
... older lesions, with pe- ripheral inflammatory activity, rather could be ascribed to secondary capillary hyperemia and/or ...in multiple sclerosis plaques (15) and is also supported by dynamic MR ...
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Revisiting Notch in remyelination of multiple sclerosis lesions
... demyelinating lesions; however, why these precursors do not differentiate into mature oligodendrocytes and remyelinate axons is ...MS lesions and that Notch1 ...
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An Automated Statistical Technique for Counting Distinct Multiple Sclerosis Lesions
... smaller) lesions rather than fewer (and larger) ...of lesions nor the amount of tissue damage alone captures all rele- vant clinical information and instead suggests that they should be considered ...of ...
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Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status
... MS lesions all foamy macrophages express CD40, CD86 CD64 and CD32 indicative of an M1 pheno- ...active lesions and the pres- ence of co-stimulatory molecules CD86 and CD40 is de- scribed before in the CNS ...
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Magnetization transfer: a potential method to determine the age of multiple sclerosis lesions
... Normal-appearing white matter in all of the patients with multiple sclerosis had magnetization transfer effect values ranging from 0.41 to 0.45.. The magnetization transfer effect value [r] ...
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The landscape of myeloid and astrocyte phenotypes in acute multiple sclerosis lesions
... MS lesions – one demyelinating and one post-demyelinating – to examine the cellular het- erogeneity of myeloid cells and astrocytes based on thir- teen markers known to be expressed by activated glial cells in MS ...
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Differential expression of glucose-metabolizing enzymes in multiple sclerosis lesions
... MS lesions, reduce αKGDH expression in vitro [3, 6, ...MS lesions, demyelinated axons are reported to be in a state of virtual hypoxia, which may also contribute to decreased αKGDH expression ...
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Identification of Chronic Active Multiple Sclerosis Lesions on 3T MRI
... Disclosures: Martina Absinta—UNRELATED: Grant: National Multiple Sclerosis Society and Conrad N. Hilton Foundation.* Daniel S. Reich—UNRELATED: Grants/Grants Pending: Vertex Pharmaceuticals*; Payment for ...
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Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions
... immunocytochemistry and FACS for immunoreactivity for lymphotoxin (LT) and TNF. Both cytokines were identified in acute and chronic active MS lesions but were absent from chronic silent lesions. LT was ...
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The relevance of cortical lesions in patients with multiple sclerosis
... performed with Jim software (Xinapse Systems Ltd., Northants (UK); http://www.xinapse.com). Global cortical thickness evaluation was performed with the semi- automated Freesurfer image analysis suite based on MPRAGE ...
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Association of Developmental Venous Anomalies with Demyelinating Lesions in Patients with Multiple Sclerosis
... The relationship of demyelination and DVAs is underreported, despite the presence of a central vein as a known phenomenon with multiple sclerosis plaques. This may be due in part to lim- itations of ...
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Improved Visualization of Cortical Lesions in Multiple Sclerosis Using 7T MP2RAGE
... settings. Lesions were identified in the axial plane, with the option to confirm them on sagittal and coronal ...images. Lesions had to be hypointense on MP2RAGE images and/or hyperintense on T2* images and ...
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Monthly intravenous methylprednisolone in relapsing-remitting multiple sclerosis - reduction of enhancing lesions, T2 lesion volume and plasma prolactin concentrations
... enhancing lesions during the baseline period, a potential alternative explanation for the reduction of enhancing lesions would be "regression to the ...active lesions during the baseline period ...
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Sexual Dysfunction in Iranian Azeri Women With Multiple Sclerosis: Levels and Correlates
... questionnaire, Multiple Sclerosis Intimacy and Sexuality Questionnaire-19 (MSISQ-19), Fatigue Severity Scale (FSS), and Beck Depression Inventory-Short Form (BDI-13) ...
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Cortical Lesions in Multiple Sclerosis: Combined Postmortem MR Imaging and Histopathology
... intracortical lesions (types II–IV), which are difficult to visualize with MR im- aging, do not show substantial T lymphocyte infiltra- ...GM-WM lesions, which are better detectable with MR imaging, do ...
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Advances in Targeted Therapies III, Nassau, Bahamas, 27 April 1 May 2001
... pre-existing multiple sclerosis showed worsening of lesions detected by MRI; in one patient treated for Crohn’s disease, multiple sclerosis developed de novo; and one patient with RA ...
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Improved detection of enhancing and nonenhancing lesions of multiple sclerosis with magnetization transfer
... enhancing lesions on conventional T1-weighted and T1- weighted magnetization transfer ...enhancing lesions and 63 nonen- hancing ...for lesions was con- trast enhancement on either T1-weighted or ...
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High Signal Periventricular Lesions in Patients with Sarcoidosis: Neurosarcoidosis or Multiple Sclerosis?
... We report five patients with clinical and biopsy- or Kveim test-proved sarcoidosis with CNS symptoms in whom isolated periventricular with occasional subcortical lesions were the only fi[r] ...
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Complement is activated in progressive multiple sclerosis cortical grey matter lesions
... matter lesions of the deeper cortical laminae are characterised as type I (involving both the white and grey matter) or type IV (involving the entire vertical extent of the cortex but without affecting the ...
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