peptide-major histocompatibility complex (pMHC)
Comparison of peptide–major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells
... 1. Peptide–major histocompatibility complex (pMHC) dextramers bind CD8 + T cells substantially better than tetramers when T cell receptor (TCR)–pMHC affinity is ...540–548 peptide ...
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Fine structure of a virus-encoded helper T-cell epitope expressed on FBL-3 tumor cells.
... To understand peptide-major histocompatibility complex MHC interactions and the subsequent recognition of peptides by specific T cells, we used peptides of decreasing lengths to determin[r] ...
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Initial Studies for the Characterization of a Major Histocompatibility Complex Class I Restricted, Peptide-Specific Cytotoxic T Lymphocyte Response in Dogs.
... NP396 peptide, an additional H2- D b binding peptide, NP366 (23, 24), was tested and also failed to stabilize DLA-88 (data not ...of peptide treatment (data not shown). Importantly, the NP396 ...
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The Major Histocompatibility Complex Class I Genes of Zebrafish.
... signal peptide and transmembrane sequences present in Ula and Uma might also indicate that the molecules undergo specialized trafficking rather than ubiquitous expression at the cell ...
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Major Histocompatibility Complex Class II Molecule-Human Immunodeficiency Virus Peptide Analysis Using a Microarray Chip
... Major histocompatibility complex (MHC) class II alleles, cell surface glycoproteins with a high degree of allelic poly- morphism (8), are constitutively expressed on professional an- tigen-presenting ...
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Molecular Determinants of Peptide Binding to Two Common Rhesus Macaque Major Histocompatibility Complex Class II Molecules
... Finally, our analysis has mapped a number of SIV-derived peptides which bind the two Mamu-DR molecules studied. The results of experiments with PBMC derived from SIV- vaccinated macaques have directly demonstrated that ...
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Diverse Peptide Presentation of Rhesus Macaque Major Histocompatibility Complex Class I Mamu-A*02 Revealed by Two Peptide Complex Structures and Insights into Immune Escape of Simian Immunodeficiency Virus
... 74). Peptide YY9 (YTSGPGIRY) and GY9 (GSENLKSLY), derived from the SIV Nef and Gag proteins, respectively, are two of the earliest-defined typical Mamu-A*02-restricted epitopes, which are commonly used in ...
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An Efficient and Versatile Mammalian Viral Vector System for Major Histocompatibility Complex Class I/Peptide Complexes
... and/or peptide absence leads to misfolding and degrada- tion of the MHC class I heavy chain because of the “quality control” function in the endoplasmic reticulum (ER) ...
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Development and Use of Multimeric Major Histocompatibility Complex Molecules
... Recent studies have also highlighted the use of multimeric MHC in analysis of the maturation of immune responses. In- vestigators have shown, by using multimeric MHC, that with there is an avidity maturation of immune ...
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Investigating and Manipulating Major Histocompatibility Complex (MHC) Class I-Restricted Peptide Epitopes and Cognate T-cell Responses.
... presence of accessory membrane-spanning domains within the canine and feline TAP proteins that have been shown in other species to interact with chaperone molecules during MHCI folding to increase peptide loading ...
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Virus and cytotoxic T lymphocytes: crucial role of viral peptide secondary structure in major histocompatibility complex class I interactions.
... Since the stabilization measured could presumably result from a nonspecific coating process of the cell surface rather than from direct binding of the peptide to Db, we next used a Db-sp[r] ...
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Major Histocompatibility Complex (MHC) Genes and Disease Resistance in Fish
... Allelic variation in fish classical MHC class I. The first solid study on allelic polymorphism in fish classical MHC class I was performed in shark [51], showing a similar level of allelic variation as known in mammals ...
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Gene duplication and fragmentation in the zebra finch major histocompatibility complex
... Phylogenetic analyses highlight the clustering of Class IIB loci by species rather than by orthology relation- ships, suggesting a history of concerted evolution, at least on portions of the genes [38,60,61]. We did, ...
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Human Cytomegalovirus Disrupts the Major Histocompatibility Complex Class I Peptide-Loading Complex and Inhibits Tapasin Gene Transcription
... Remarkably, whereas the disruption of MHC I interaction could be documented for tapasin, ERp57, and TAP, the MHC I-calreticulin interaction was not reduced in infected cells (Fig. 1D). This drew our attention to a recent ...
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The role of major histocompatibility complex molecules in luteal function
... Schematic representation depicting processing of antigens presented by class I MHC molecules. 1) Intracellular proteins are proteolytically degraded within proteasomes. 2) Proteolytic degradation of intracellular ...
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SVM BASED PREDICTION OF MAJOR HISTOCOMPATIBILITY COMPLEX BINDERS: EXPRESSION AND ANALYSIS OF Mesobuthus Tamulus PEPTIDE
... the peptide binders of neurotoxin from Mesobuthus tamulussequence to MHC- I molecules are as 11mer_H2_Db, 10mer_H2_Db, 9mer_H2_Db, ...of peptide MHC class I binding; proteasomal C terminal cleavage and TAP ...
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TARGETING TOOLS FOR A DNA VACCINE CARRIER, A DESIGN IN PREVENTION OF CANCER
... recognize peptide antigens on the cell surface of an antigen-presenting cell in association with a class major histocompatibility complex (MHC) ...
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The Major Histocompatibility Complex in Song Sparrows: Immunity, Signals, and Mate Choice
... smelled by conspecific receivers. Similarly, female three-spined sticklebacks (Gasteroseus aculeatus) assess MHC profiles of potential mates based on their MHC peptide ligands (Milinski et al. 2005). Chemical ...
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Physical Association of the K3 Protein of Gamma-2 Herpesvirus 68 with Major Histocompatibility Complex Class I Molecules with Impaired Peptide and β2-Microglobulin Assembly
... Sec61 complex of proteins, implying that the same complex that translocates nascent proteins from the cytosol to the ER appears to be involved in US2-induced dislocation ...
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Viral Proteins Interfering with Antigen Presentation Target the Major Histocompatibility Complex Class I Peptide-Loading Complex
... a peptide able to induce final maturation; alternatively, the MHC-I may be from a HLA allele less prone to binding the peptide-loading complex or may be unable to bind the peptide-loading ...
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