Recombination and selection analysis
Deleterious background selection with recombination.
... for distinguishing between the background selection and the hitchhiking models. Many properties of genetic variation depend on the effective population size. The analysis th[r] ...
13
Interplay of recombination and selection in the genomes of Chlamydia trachomatis
... from selection in genes for host trop- ism or increased virulence may be transmitted fre- quently to other members of the species through ...of recombination and selection in this pathogen, we per- ...
16
Distortions in Genealogies due to Purifying Selection and Recombination
... how selection distorts the shapes of genealogies, and how this depends upon the parameters ...of recombination, sites far away from one another become effectively independent, it may be possible to detect ...
16
Estimating Diversifying Selection and Functional Constraint in the Presence of Recombination
... diversifying selection or functional constraint in a sample of gene ...been recombination in the evolutionary history of the sequences, reconstructing a single phylogenetic tree is not appropriate, and ...
15
Genetic Mapping and Genomic Selection Using Recombination Breakpoint Data
... infer recombination breakpoints, which then facilitate construction of ...genomic selection, we developed a method to create user-de fi ned (arti fi cial) bins, in which breakpoints are allowed within ...data ...
13
Therapeutic targeting and patient selection for cancers with homologous recombination defects
... phenotypic analysis of forma- lin-fixed, paraffin-embedded tumor tissue collected by biopsy or ...this analysis cannot identify tumors with epigenetically silenced HR genes and other yet unknown causes of ...
19
Optimisation of T cell receptors using in vivo recombination and selection
... the analysis of the thymi in Marilyn TCR (CDR3β diversifying) retrogenic mice, we observed a higher frequency of SPCD4 relative to SPCD8 thymocytes suggesting a more efficient positive selection process ...
193
AN ANALYSIS OF VARIABILITY ARISING THROUGH RECOMBINATION
... The second hypothesis states that selection favors particular hetero- zygotes and thereby builds up selected series of alleles at all (or at least many) loci-the particular al[r] ...
36
Fixation Probability in a Two-Locus Model by the Ancestral Recombination–Selection Graph
... mortality selection determined at two loci in a finite haploid population to ascertain the ...coalescence, recombination, or selection events backward in time, whose limit as the population size ...
17
The Relationship of Nucleotide Polymorphism, Recombination Rate and Selection in Wild Tomato Species
... background selection model was also favored by I nnan and S tephan (2003) who found that in RFLP data (M iller and T anksley 1990), levels of polymorphism in ...low recombination. Accord- ing to their ...
11
Natural Selection on Synonymous Sites Is Correlated With Gene Length and Recombination in Drosophila
... with recombination genes in the final set of 537 coding regions is ...interspecific analysis, the number of synonymous (K s ) and by the otherwise inexplicable finding that ...
11
SELECTION ON RECOMBINATION IN CLINES
... Decreasing s decreased the strength of selection for increased recombination, in all cases tested, and the rate of change in frequency of the modifier was often highest when [r] ...
9
Selection for Recombination in Structured Populations
... either selection in the haploid phase followed by random mating or ran- dom mating followed by selection in the diploid phase, after which meiosis occurs to produce an effectively in- finite population of ...
17
The coalescent process in models with selection and recombination.
... The statistical properties of the process describing the genealogical history of a random sample of genes at a selectively neutral locus which is linked to a locus at w[r] ...
10
SELECTION ON RECOMBINATION IN A MULTI-LOCUS SYSTEM
... WILLS and MILLER (1976) proposed “a model for outbreeding populations in which there can be selection for relatively free recombination,” which they claim “does not rely on [r] ...
6
LINKAGE DISEQUILIBRIUM, SELECTION AND RECOMBINATION AT THREE LOCI
... Additionally, interactions among three loci are important in reducing the strength of selection necessary to maintain a given level of disequilibrium, relative to a two-[r] ...
12
SELECTION FOR RECOMBINATION IN PARTIALLY SELF-FERTILIZING POPULATIONS
... I n particular, HOLDEN suggested by analogy with the random-mating case (and confirmed by computer studies) that, with the form of fitness matrix which he studied, th[r] ...
8
GENETIC RECOMBINATION AND CLONAL SELECTION IN DROSOPHILA MERCATORUM
... homozygous genotypes+ xa d.f. -f Fitness estimates of the original S-Im and RSB-Br parental genotypes are given in the first and last columns, respectively. Fitness estimates o[r] ...
18
The Evolution of Recombination: Removing the Limits to Natural Selection
... We assume that the modifier allele is selectively neu- tral except for its effects on the fixation probability of new mutations; that is, we focus on allele frequency [r] ...
28
The effects of normalizing and disruptive selection on genes for recombination
... Robertson (1956), ignoring linkage disequilibrium, showed that, if genetic variance is additive, normalizing selection with a fixed optimum leads to genetic homozygosity.. Bulmer (19716)[r] ...