[PDF] Top 20 Analysis of the 2-kilobase latency-associated transcript expressed in PC12 cells productively infected with herpes simplex virus type 1: evidence for a stable, nonlinear structure.
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Analysis of the 2-kilobase latency-associated transcript expressed in PC12 cells productively infected with herpes simplex virus type 1: evidence for a stable, nonlinear structure.
... the 2-kb LAT gene transcript. Stable RNA molecules derived from splicing reactions have been found to be present in a nonlinear form (8, 34, ...the 2-kb LAT gene transcript, it ... See full document
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Selection of a nonconsensus branch point is influenced by an RNA stem-loop structure and is important to confer stability to the herpes simplex virus 2-kilobase latency-associated transcript.
... Cos-1 cells, total RNA was extracted and subjected to Northern blot analysis as described in Materials and ...the 2-kb LAT intron, upstream of the lambda phage ...normal 2-kb LAT ... See full document
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Analysis of Protein Expression from within the Region Encoding the 2.0-Kilobase Latency-Associated Transcript of Herpes Simplex Virus Type 1
... and latency, while a second promoter was active in tissue culture cells, ...latently infected cells, while the ...LAT-GFP virus did not express detectable levels of GFP either in ... See full document
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The 2-Kilobase Intron of the Herpes Simplex Virus Type 1 Latency-Associated Transcript Has a Half-Life of Approximately 24 Hours in SY5Y and COS-1 Cells
... The herpes simplex virus type 1 (HSV-1) 2-kb latency-associated transcript (LAT) is a stable intron, which accumulates in cells both ... See full document
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Evidence that two latency-associated transcripts of herpes simplex virus type 1 are nonlinear.
... human herpes simplex virus type 1 (HSV-1) establishes latency in those pe- ripheral neurons which send projections to the lytically in- fected ...In productively ... See full document
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Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene Promotes Neuronal Survival
... the stable LAT locus introns known as the LATs ...of latency is not yet ...ganglia infected with LAT null mutants and that at least some of the cells undergoing apoptosis are neurons ... See full document
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Herpes Simplex Virus Type 1 2-Kilobase Latency-Associated Transcript Intron Associates with Ribosomal Proteins and Splicing Factors
... During latency of herpes simplex virus type 1 in sensory neurons, the transcription of viral genes is restricted to the latency-associated transcripts ...The ... See full document
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The Locus Encompassing the Latency-Associated Transcript of Herpes Simplex Virus Type 1 Interferes with and Delays Interferon Expression in Productively Infected Neuroblastoma Cells and Trigeminal Ganglia of Acutely Infected Mice
... provide evidence that a factor encoded by the LAT locus delayed RNA and protein expression of certain IFNs in neuroblastoma cells (SK-N-SH or neuro-2A) and TG of infected mice but not in HEL ...in ... See full document
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The Stable 2.0-Kilobase Intron of the Herpes Simplex Virus Type 1 Latency-Associated Transcript Does Not Function as an Antisense Repressor of ICP0 in Nonneuronal Cells
... ICP0 transcript has given rise to speculation that the ...served stable structure of the abundant ...limited evidence in support of this ... See full document
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The Stable 2-Kilobase Latency-Associated Transcript of Herpes Simplex Virus Type 1 Can Alter the Assembly of the 60S Ribosomal Subunit and Is Exported from Nucleus to Cytoplasm by a CRM1-Dependent Pathway
... were expressed as a percentage of the total counts in a ...fected cells, we found a normal distribution of 28S rRNA, with two visible peaks, one for 60S and one for 80S ...when cells were transfected ... See full document
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The herpes simplex virus type 1 2.0-kilobase latency-associated transcript is a stable intron which branches at a guanosine.
... latently infected neurons ...LATin, expressed in both trans- fected and infected tissue culture cells as well as latently in- fected neurons, as a ...and infected cells ... See full document
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A Herpes Simplex Virus Type 1 Latency-Associated Transcript Mutant with Increased Virulence and Reduced Spontaneous Reactivation
... The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) gene is essential for efficient spontaneous reactivation of HSV-1 from ... See full document
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A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation.
... Latency-associated transcript (LAT) promoter deletion mutants of herpes simplex virus type 1 have a reduced capacity to reactivate following adrenergic induction in ... See full document
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In Vivo Knockdown of the Herpes Simplex Virus 1 Latency-Associated Transcript Reduces Reactivation from Latency
... 4 Analysis of rabbit TG for AAV transduction, LAT expression, and HSV-1 DNA ...latently infected rabbit TG ...which expressed GFP from the CBA ...satellite cells present in the ...each ... See full document
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Physical characterization of the herpes simplex virus latency-associated transcript in neurons.
... 1194 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest RNA transfer Northern blot analysis was used to perform the physical characterization of the transcript expressed i[r] ... See full document
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Herpes Simplex Virus Type 1 Latency-Associated Transcript Reduces Human Neuroblastoma Cell Proliferation
... Herpes simplex virus type 1 latency associated transcript is plentifully expressed through virus ...expression analysis showed that LAT ... See full document
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A Novel Herpes Simplex Virus Type 1 Transcript (AL-RNA) Antisense to the 5′ End of the Latency-Associated Transcript Produces a Protein in Infected Rabbits
... dLAT2903 virus per eye, and serum was collected from individual rabbits 57 days ...which latency had been well ...wild-type- infected rabbits (lanes 1, 2, and 3) recognized a ... See full document
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Neuronal Subtype Determines Herpes Simplex Virus 1 Latency-Associated-Transcript Promoter Activity during Latency
... ABSTRACT Herpes simplex virus (HSV) latency in neurons remains poorly under- stood, and the heterogeneity of the sensory nervous system complicates mechanis- tic ...HSV latency. ... See full document
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Regions of the Herpes Simplex Virus Type 1 Latency-Associated Transcript That Protect Cells from Apoptosis In Vitro and Protect Neuronal Cells In Vivo
... the latency-associated transcript (LAT) region of herpes simplex virus type 1 (HSV-1) is effective at blocking virus-induced apoptosis both in vitro ... See full document
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Herpes Simplex Virus Type 1 Latently Infected Neurons Differentially Express Latency-Associated and ICP0 Transcripts
... the virus rapidly spreads to the nervous system through sensory, autonomic, and motor neuronal pathways and finally becomes latent, not only in the TG, but also in numerous other struc- tures that are connected to ... See full document
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