[PDF] Top 20 Article: Formulation and evaluation of metformin HCl floating microspheres

... preparing floating microspheres was to extend the gastric residence time of a ...The microspheres were spread over the surface of a simulated gastric fluid and the fraction of microspheres ... See full document

... ABSTRACT: Floating matrix tablets of Metformin hydrochloride were developed and evaluated to increase bioavailability by increasing gastric residence time and sustained release of drug in the upper part of ... See full document

... of Metformin Hydrochloride (Anti diabetic drug) loaded floating microspheres with polymers HPMC K100 M, sodium ...the floating microspheres was sufficiently controlled. The ... See full document

... weight number of floating microspheres was transferred in dissolution vessel containing 0.1 N HCl (pH 1.2) maintained at 37 ± 0.5°C. The rotation of apparatus shaft was fixed at a speed of 100 rpm. 5 ... See full document

... Acetate microspheres was determined by dispersing 50 mg formulation (accurately weighed) in 10 mL acetone, followed by agitation with a magnetic stirrer for 12 h to dissolve the polymer and to extract the ... See full document

... the floating behavior of various polymer ...of floating microparticles were placed in each of four 50 ml beakers containing 20 ml of ...0.1N HCl containing ...r.p.m. Floating ... See full document

... indexof microspheres was determined by placing the microspheres in thebasket of dissolution apparatus using dissolution mediumas ...0.1N HCl at ...containing microspheres waswithdrawn, blotted ... See full document

... prepared floating microspheres were evaluated with respect to particle size distribution, floating behavior, drug content, entrapped morphology and in-vitro release ... See full document

... develop floating microspheres containing rabeprazole. Floating microspheres were prepared by solvent evaporation technique by varying the drug polymer ...The floating ... See full document

... Dimethylbiguanide floating microspheres to improve the bioavailability by increasing residence time in ...stomach. Metformin is an anti- hyperglycemic agent which improves glucose tolerance in ... See full document

... Ciprofloxacin HCl belong to the fluoroquinoline derivatives which is widely used in the long term therapy for treatment of a wide range of infections including anthrax, biliary tract infection, bone and joint ... See full document

... of floating microspheres were a high buoyancy and sufficient release of drug in ...N HCl, so it was necessary to select an appropriate balance between buoyancy and drug release ...that ... See full document

... Metformin Hcl is a biguanide antidiabetic agent which is used in the management of type 2 diabetes and it is preferably absorbed in the upper part of the GIT and readily soluble in gastric pH of the ... See full document

... on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric ...the formulation and technological point of ... See full document

... buoyant. Floating lag times were in the range of 58 to 540 ...showed floating lag time of 135, 105, 370 sec, respectively, and remain buoyant for 10, 8, 5h, respectively, Table 4, till completely ...hand, ... See full document

... of Metformin hydrochloride and Glipizide were ...disintegrants. Metformin hydrochloride was formulated by using Hydroxy Propyl Methyl Cellulose as the matrix forming polymer and was directly ...optimized ... See full document

... the formulation, which is compatible with the ...pure Metformin Hydrochloride and microspheres loaded with Metformin Hydrochloride were recorded to check drug polymer interaction and stability ... See full document

... Practical drug content was analyzed by using the following procedure, weighed amount of Timolol floating microspheres equivalent to eight mg of Timolol floating microspheres was dissolved in ... See full document

... Tartarate Floating Microspheres was successfully prepared by solvent diffusion method using ethyl cellulose and HPMC in different ratios and with different stirring speeds and different ...from ... See full document

... Tablet hardness is defined as the force required to break a tablet. Tablets require a certain amount of strength, or hardness and resistance to withstand the mechanical shocks during handling, manufacturing, packaging ... See full document