[PDF] Top 20 Attenuated replication of human immunodeficiency virus type 1 with a didanosine-selected reverse transcriptase mutation.
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Attenuated replication of human immunodeficiency virus type 1 with a didanosine-selected reverse transcriptase mutation.
... Leu74Val mutation (data not ...inefficient replication of Leu74Val mutants in cloned virus is due to the RT mutation and not to an effect of the vector ...Leu74Val virus, the ... See full document
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Decreased Processivity of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (RT) Containing Didanosine-Selected Mutation Leu74Val: a Comparative Analysis of RT Variants Leu74Val and Lamivudine-Selected Met184Val
... Attenuated replication of HIV-1 containing RT mutation Leu74Val in the HXBc2 ...that didanosine-selected mutation Leu74Val confers a replica- tion disadvantage to the ... See full document
9
Reversion of a Human Immunodeficiency Virus Type 1 Matrix Mutation Affecting Gag Membrane Binding, Endogenous Reverse Transcriptase Activity, and Virus Infectivity
... and virus assembly (39) resulting from single amino acid substitutions in ...the virus life cycle, we have obtained and characterized a viral revertant of a residue 20 mutant ...20LK mutation but ... See full document
10
HuR interacts with human immunodeficiency virus type 1 reverse transcriptase, and modulates reverse transcription in infected cells
... HIV-1 replication cycle and for both the early and late steps of reverse transcription, in ...the reverse transcription reaction observed when HuR was overexpressed is consistent with these ... See full document
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Hypersusceptibility to Substrate Analogs Conferred by Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase
... all reverse transcriptases and RNA-dependent viral polymerases (Fig. 1) (4, 21, ...(Fig. 1). Although a few mutations in HIV-1 RT motif B have been shown to confer drug resistance (25, 36, 39, ... See full document
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Construction and Characterization of a Temperature-Sensitive Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutant
... (ts) human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) mutant was generated by charged-cluster-to-alanine ...mutant virus, containing ... See full document
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Mutation of the Methylated tRNA Residue A58 Disrupts Reverse Transcription and Inhibits Replication of Human Immunodeficiency Virus Type 1
... a replication-competent HIV-1 mutant that expresses the murine Thy-1 gene in place of nef ...if reverse transcription fails to terminate at residue 58 of the tRNA ... See full document
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Second-Site Reversion of a Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutant That Restores Enzyme Function and Replication Capacity
... the reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) lead to enzymes displaying lower affinity for deoxynucleoside triphosphates (dNTPs) ... See full document
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Replication of Phenotypically Mixed Human Immunodeficiency Virus Type 1 Virions Containing Catalytically Active and Catalytically Inactive Reverse Transcriptase
... E478Q mutation did not efficiently synthesize ⫺sssDNA. The D443N mutation was reported to have minimal effects on polymerase activity when homopolymeric templates were used as sub- strates (39); however, ... See full document
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Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase.
... of replication, and lacZ a peptide gene sequences from the HIV-1 shuttle vector proviral DNA ...were selected in the presence of the 5-bromo-4-chloro-3-indolyl-b- D -thiogalactopyranoside (IPTG) ... See full document
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Amino Acid Substitutions at Position 190 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Increase Susceptibility to Delavirdine and Impair Virus Replication
... single replication cycle assay as previously described ...aa 1 to ...patient virus in plasma, RTVs were prepared and tested as large pools ...leukemia virus. High-titer virus stocks ... See full document
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Influence of Reverse Transcriptase Variants, Drugs, and Vpr on Human Immunodeficiency Virus Type 1 Mutant Frequencies
... RNA-DNA replication intermediate, allowing the DNA to act as a template for the DNA-dependent DNA polymerase activ- ity of RT to complete synthesis of the double-stranded viral ...during reverse ... See full document
10
Role for Human Immunodeficiency Virus Type 1 Tat Protein in Suppression of Viral Reverse Transcriptase Activity during Late Stages of Viral Replication
... in reverse transcription, we pre- pared recombinant Tat proteins and studied them in reconsti- tuted cell-free RT ...(i.e., 1-exon-Tat) could not. Conversely, HIV-1 molecular clones expressing ... See full document
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A Role of Template Cleavage in Reduced Excision of Chain-Terminating Nucleotides by Human Immunodeficiency Virus Type 1 Reverse Transcriptase Containing the M184V Mutation
... L33-AZT primer annealed to unlabeled R52 or D50 template in RB-10 buffer with the four dNTPs at 10 M (each) and 3.2 mM ATP or 15 or 50 M pyrophosphate (PP i ) in a final volume of 10 l. The ATP and dNTPs were ... See full document
12
Comparison of Sequencing by Hybridization and Cycle Sequencing for Genotyping of Human Immunodeficiency Virus Type 1 Reverse Transcriptase
... codons 1 to 242 was sequenced by fluoresceinated primer extension (ThermoSequenase Fluorescent Labeled Primer Cycle Sequencing Kit; Amersham Life Science, Buckinghamshire, En- gland), followed by gel ... See full document
7
Mutations in the Thumb Allow Human Immunodeficiency Virus Type 1 Reverse Transcriptase To Be Cleaved by Protease in Virions
... during human immu- nodeficiency virus type 1 (HIV-1) replication, most mutations are rapidly lost because they have a negative effect on viral ...viral replication is not ... See full document
9
Reversion of the M184V Mutation in Simian Immunodeficiency Virus Reverse Transcriptase Is Selected by Tenofovir, Even in the Presence of Lamivudine
... methionine-to-valine mutation in codon 184 (M184V) in reverse transcriptase (RT) of human immu- nodeficiency virus type 1 (HIV-1) or simian immunodeficiency ... See full document
11
Template Usage Is Responsible for the Preferential Acquisition of the K65R Reverse Transcriptase Mutation in Subtype C Variants of Human Immunodeficiency Virus Type 1
... Antiretroviral drugs (ARVs) work by inhibiting the replica- tion of human immunodeficiency virus type 1 (HIV-1). How- ever, little information is available as to whether subtype ... See full document
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The M184V Mutation Reduces the Selective Excision of Zidovudine 5′-Monophosphate (AZTMP) by the Reverse Transcriptase of Human Immunodeficiency Virus Type 1
... M184V mutation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) causes resistance to lamivudine, but it also increases the ... See full document
9
Effects of zidovudine-selected human immunodeficiency virus type 1 reverse transcriptase amino acid substitutions on processive DNA synthesis and viral replication.
... In structural models of RT, amino acid residues 67, 70, and 215 as well as 74 are in close proximity to the RNA template (20, 27, 52). Therefore, the set of AZT resistance mutations D67N, K70R, T215Y, and K219Q has been ... See full document
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