[PDF] Top 20 In vivo binding of wild-type and mutant human immunodeficiency virus type 1 Rev proteins: implications for function.
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In vivo binding of wild-type and mutant human immunodeficiency virus type 1 Rev proteins: implications for function.
... HAINES' Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina 29425-2230,1 and Department of Microbiology, University of Leicester S[r] ... See full document
7
Inhibition of Human Immunodeficiency Virus Type 1 Rev Function by a Dominant-Negative Mutant of Sam68 through Sequestration of Unspliced RNA at Perinuclear Bundles
... this mutant blocks the Rev-mediated transport of unspliced viral RNA throughout the cytoplasm ...and Rev, perinuclear bundles are formed that con- tain both unspliced env RNA and ...inhibits ... See full document
13
Inhibition of human immunodeficiency virus type 1 replication is enhanced by a combination of transdominant Tat and Rev proteins.
... structural proteins known as trans- dominant or dominant negative mutant proteins have efficacy in preventing human immunodeficiency virus type 1 (HIV-1) ... See full document
6
Regions of Human Immunodeficiency Virus Type 1nef Required for Function In Vivo
... biologic function (14, 39, ...(deletions 1, 2, and 4) of this putative anchor domain had no effect on viral replication or ...a virus with a pathogenicity phenotype identical to that of ... See full document
8
Membrane vesiculation function and exocytosis of wild-type and mutant matrix proteins of vesicular stomatitis virus.
... viral proteins, induces the formation of lipoprotein ves- icles which bud from the external surface of the plasma mem- brane of mammalian cells is presented ...membrane binding in vivo and in vitro ... See full document
5
Structural analysis of wild-type and mutant human immunodeficiency virus type 1 Tat proteins.
... These mutants, wild type in structure but reduced in activity, identify residues in the wild-type protein that may directly contact other molecules during Tat function... STRUCTURE OF HI[r] ... See full document
9
Restriction of Human Immunodeficiency Virus Type 1 Rev Function in Murine A9 Cells Involves the Rev C-Terminal Domain
... The human immunodeficiency virus type 1 (HIV-1) Rev function is essential for the cytoplasmic transport of unspliced and singly spliced viral transcripts and thus ... See full document
7
Expression and Function of Chemokine Receptors on Human Thymocytes: Implications for Infection by Human Immunodeficiency Virus Type 1
... To further characterize the cross-reactivity of MAb 3A9 and 5C7 with CCR8, we deleted amino acids 2 through 4 of CCR8 to create CCR8⌬2–4. DNA encoding this mutant form of CCR8 was then introduced into L1.2 cells ... See full document
9
Use of a human immunodeficiency virus type 1 Rev mutant without nucleolar dysfunction as a candidate for potential AIDS therapy.
... retrovirus human immuno- deficiency virus type 1 (HIV-1) encodes some accessory pro- teins in addition to viral structural proteins (reviewed in ref- erence ...protein Rev ... See full document
9
Reversion of a human immunodeficiency virus type 1 integrase mutant at a second site restores enzyme function and virus infectivity.
... deletion mutant 50-288 yielded 10 to 20% of wild-type levels of 3 9 processing and DNA strand transfer activities ...and wild-type integrases displayed equal metal-independent DNA ... See full document
8
RNA aptamers selected to bind human immunodeficiency virus type 1 Rev in vitro are Rev responsive in vivo.
... the wild-type RBE are prerequisites for Rev responsiveness or (ii) that interactions between Rev and any complementary RNA shape in place of the RBE could promote Rev ...between ... See full document
9
Transdominant repressors for human T-cell leukemia virus type I rex and human immunodeficiency virus type 1 rev function.
... The rex genes encoded by the mutant clones pLHRexM2, pLHRexM7, and pLHRexM8 were able to inhibit wild-type function of the HIV-1 Rev protein Fig.. The expression of Rev was Mnonitored by[r] ... See full document
8
Repair of a Rev-Minus Human Immunodeficiency Virus Type 1 Mutant by Activation of a Cryptic Splice Site
... of wild-type, mutant, and revertant genotype and isolated viral RNA at 2 days ...all virus variants ...exon 1-2 splice product (using 5⬘ ss #4 and 3⬘ ss #7), and this was verified by ... See full document
6
Potentiation of human immunodeficiency virus type 1 Tat by human cellular proteins.
... Time-dependent assembly of Tat-activated transcription complexes. In vitro preinitiation complexes assemble in a step- wise manner, and some stages have been shown to be rate limiting (18). The formation of transcription ... See full document
5
In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor.
... Transcriptional activation of homologous viral long terminal repeats by the human immunodeficiency virus type 1 or the human T-cell leukemia virus type 1 tat proteins occurs in the absen[r] ... See full document
10
Efficient replication of human immunodeficiency virus type 1 requires a threshold level of Rev: potential implications for latency.
... To determine whether a functional threshold level of Rev is required to allow efficient HIV-1 replication, CD4-positive HeLa cells, constitutively expressing a Rev-deficient provirus, we[r] ... See full document
5
Functional mapping of the human immunodeficiency virus type 1 Rev RNA binding domain: new insights into the domain structure of Rev and Rex.
... As demonstrated previously 21, the protein encoded by Rex[vNLS33-46] was directed to the correct nucleolar compartment by a stretch of 14 amino acid residues Rev amino acid residues 33 t[r] ... See full document
5
Incorporation of excess wild-type and mutant tRNA(3Lys) into human immunodeficiency virus type 1.
... When COS-7 cells are transfected with a plasmid containing both HlV-1 proviral DNA and a mutant amber suppressor tRNA3YS gene in which the anticodon is changed from TTT to CTA, there is [r] ... See full document
8
Reconstruction and Function of Ancestral Center-of-Tree Human Immunodeficiency Virus Type 1 Proteins
... of human immunodeficiency virus type 1 (HIV-1) and its capacity to mutate and escape host immune responses are major challenges for AIDS vaccine ...regulatory proteins, ... See full document
8
Conserved functional organization of the human immunodeficiency virus type 1 and visna virus Rev proteins.
... The hybrid protein bearing the basic domain of the visna virus Rev protein and the leucine domain of HIV-1 Rev, termed L/Rev, proved fully able to trans activate visna virus structural p[r] ... See full document
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