[PDF] Top 20 Combination of Drugs and Drug-Resistant Reverse Transcriptase Results in a Multiplicative Increase of Human Immunodeficiency Virus Type 1 Mutant Frequencies
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Combination of Drugs and Drug-Resistant Reverse Transcriptase Results in a Multiplicative Increase of Human Immunodeficiency Virus Type 1 Mutant Frequencies
... to increase the mutation rates of SNV and MLV ...AZT- resistant RT has higher fidelity not lower fidelity. Since AZT- resistant RTs were observed to have lower in vivo fidelity (25), the excision of ... See full document
7
Effects of Human Immunodeficiency Virus Type 1 Resistance to Protease Inhibitors on Reverse Transcriptase Processing, Activity, and Drug Sensitivity
... man immunodeficiency virus type 1 (HIV-1) replication in treated patients, particularly when used in combination with other antiretroviral agents, has been extensively documented ... See full document
5
Insertions in the Reverse Transcriptase Increase both Drug Resistance and Viral Fitness in a Human Immunodeficiency Virus Type 1 Isolate Harboring the Multi-Nucleoside Reverse Transcriptase Inhibitor Resistance 69 Insertion Complex Mutation
... (MDR) human immunodeficiency virus type 1 (HIV-1) strains, with reduced susceptibilities to antiret- roviral drugs from two or more classes, are now commonly found in ... See full document
7
Individual Contributions of Mutant Protease and Reverse Transcriptase to Viral Infectivity, Replication, and Protein Maturation of Antiretroviral Drug-Resistant Human Immunodeficiency Virus Type 1
... testing. Results of single-cycle infec- tivity in GHOST cells indicate a good correlation with repli- cation kinetics and RT activities of recombinant clones tested in ...to mutant PR, while improving the ... See full document
10
Increased polymerase fidelity of E89G, a nucleoside analog-resistant variant of human immunodeficiency virus type 1 reverse transcriptase.
... the mutant RTs ...the increase in fidelity reported here could be a minimal ...the mutant virus (9). Most drug-resistant viruses are thought to display suboptimal fitness ... See full document
5
Attenuated replication of human immunodeficiency virus type 1 with a didanosine-selected reverse transcriptase mutation.
... cloned virus is due to the RT mutation and not to an effect of the vector ...these results are in agreement with the results of cloned Leu74Val virus, the replication kinetics of ... See full document
7
Selective Excision of AZTMP by Drug-Resistant Human Immunodeficiency Virus Reverse Transcriptase
... the combination of AZT resistance mutations M41L, D67N, K70R, T215Y, and K219Q (designated AZT-21) against wild-type RT and a mu- tant RT resistant to the nucleoside analog dideoxyinosine (ddI) ... See full document
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Human Immunodeficiency Virus Type 1 Subtype F Reverse Transcriptase Sequence and Drug Susceptibility
... the reverse transcriptase (RT) regions of the pol genes of 14 human immunodeficiency virus type 1 (HIV-1) isolates from Romanian patients, which were classified as ... See full document
5
Comparison of G-to-A Mutation Frequencies Induced by APOBEC3 Proteins in H9 Cells and Peripheral Blood Mononuclear Cells in the Context of Impaired Processivities of Drug-Resistant Human Immunodeficiency Virus Type 1 Reverse Transcriptase Variants
... mutation frequencies regarding the three different viral ...Similar results were obtained from the infection of PBMCs from donors A and B with those ...mutation frequencies of the four viral variants ... See full document
10
Effect of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Polymorphism Leu-214 on Replication Capacity and Drug Susceptibility
... Our results provide additional insights into the favorable impact of Leu-214 on the virological response to thymidine analogue-based ...our results suggest that Leu-214 not only influences viral fitness but ... See full document
6
3′-Azido-3′-Deoxythymidine (AZT) and AZT-Resistant Reverse Transcriptase Can Increase the In Vivo Mutation Rate of Human Immunodeficiency Virus Type 1
... can increase mutant frequencies and the in vivo HIV-1 mutation ...termine mutant frequencies. The mutant frequency of HIV-1 replicated with the T215Y RT variant led ... See full document
8
In Vitro Microbicidal Activity of the Nonnucleoside Reverse Transcriptase Inhibitor (NNRTI) UC781 against NNRTI-Resistant Human Immunodeficiency Virus Type 1
... wt virus, the potential utility of UC781 as an anti- HIV microbicide is strengthened by our findings that formula- tion-attainable concentrations of the compound retain microbici- dal properties against ... See full document
7
Clinical data sets of human immunodeficiency virus type 1 reverse transcriptase-resistant mutants explained by a mathematical model.
... of human immunodeficiency virus type 1 (HIV-1) infection during the clinical latency phase with drugs inhibiting reverse transcriptase (RT) reduces the ... See full document
8
Worldwide Evaluation of DNA Sequencing Approaches for Identification of Drug Resistance Mutations in the Human Immunodeficiency Virus Type 1 Reverse Transcriptase
... The drug resistance-con- ferring mutations were located at three amino acid and four independent nucleotide positions, ...a mutant (drug-resistant) geno- type was present in at least 5% ... See full document
6
A Mutation in the 3′ Region of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase (Y318F) Associated with Nonnucleoside Reverse Transcriptase Inhibitor Resistance
... EFV combination therapy revealed the accu- mulation of viruses with multiple linked NNRTI mutations following the emergence of K103N mutant viruses (1), suggest- ing the presence of drug ... See full document
5
Human Immunodeficiency Virus Mutagenesis during Antiviral Therapy: Impact of Drug-Resistant Reverse Transcriptase and Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors on Human Immunodeficiency Virus Type 1 Mutation Frequencies
... which drugs and drug resistance muta- tions alter the mutation frequency of HIV-1 subtype B and CRF01_A/E, we have conducted structural analyses by inte- grating HIV-1 RT structure-function ... See full document
13
Influence of Reverse Transcriptase Variants, Drugs, and Vpr on Human Immunodeficiency Virus Type 1 Mutant Frequencies
... of drug resistance is a major complication of human immunodeficiency virus type 1 (HIV-1) ...HIV-1 reverse transcriptase (RT) is a major target of ... See full document
10
YADD Mutants of Human Immunodeficiency Virus Type 1 and Moloney Murine Leukemia Virus Reverse Transcriptase Are Resistant to Lamivudine Triphosphate (3TCTP) In Vitro
... cleavage by the M184A mutant of HIV-1 RT. With appropriate nucleic acid substrates, HIV-1 RT makes two sets of RNase H cleavages. The primary cleavages are centered on a region about 17 nucleotides ... See full document
8
Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors.
... 4887 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Human immunodeficiency virus type 1 HIV-1-specific pyridinone reverse transcriptase RT inhibitors prevent HIV-1 rep[r] ... See full document
6
Amino Acid Substitutions at Position 190 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Increase Susceptibility to Delavirdine and Impair Virus Replication
... site-directed mutant viruses carrying the respective 190 ...reference virus (100%) tested in the same experi- ment. (A) Site-directed mutant virus ...Recombinant virus pools containing ... See full document
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