[PDF] Top 20 Construction and characterization of a herpes simplex virus type 1 mutant unable to transinduce immediate-early gene expression.
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Construction and characterization of a herpes simplex virus type 1 mutant unable to transinduce immediate-early gene expression.
... Isolation and characterisation of a herpes simplex virus type 1 mutant containing a deletion within the gene encoding the immediate early polypeptide VmwllO.. The DNA-binding domains of [r] ... See full document
10
Repression of gene expression upon infection of cells with herpes simplex virus type 1 mutants impaired for immediate-early protein synthesis.
... of gene expression which, at the experimental level, masks events in cells containing quiescent ...IE gene expression even further have been devised. Virus in1820 is in1814 with the ... See full document
7
Herpes Simplex Virus 1 Immediate-Early and Early Gene Expression during Reactivation from Latency under Conditions That Prevent Infectious Virus Production
... the virus in this sample, homogenates in other wells on the same 6-well plate were negative for virus and additional negative controls revealed no ...produced virus after the explant period is ... See full document
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Evidence that the Immediate-Early Gene Product ICP4 Is Necessary for the Genome of the Herpes Simplex Virus Type 1 ICP4 Deletion Mutant Strain d120 To Circularize in Infected Cells
... and mutant d120 virions. (A) ICP4 expression in d120- infected Vero and E5 ...ICP4-deleted mutant d120 or wild-type KOS as indicated at an MOI of ...with 1/10th of the virion lysate (30 ... See full document
9
Transactivation of Herpes Simplex Virus Type 1 Immediate-Early Gene Expression by Virion-Associated Factors Is Blocked by an Inhibitor of Cyclin-Dependent Protein Kinases
... a mutant probe in which the VP16 consensus site, TAATGARAT (R represents any purine), was changed to ...unlabeled mutant probe ...IE gene expression by Roscovitine occurs at a step following ... See full document
5
Control of VP16 Translation by the Herpes Simplex Virus Type 1 Immediate-Early Protein ICP27
... VP16 gene expres- sion, we undertook a series of experiments that carefully com- pared the levels of VP16 protein and mRNA in cells infected with HSV strains containing or lacking ...wild-type virus ... See full document
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Overexpression of the herpes simplex virus type 1 immediate-early regulatory protein, ICP27, is responsible for the aberrant localization of ICP0 and mutant forms of ICP4 in ICP4 mutant virus-infected cells.
... ICP27 expression from the endogenous ICP27 gene increased as the multiplicity ...lanes 1 and 8), and the levels of ICP27 expression increased as the multiplicities of infection of d92 (lanes 2 ... See full document
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Herpes simplex virus type 1 ICP0 regulates expression of immediate-early, early, and late genes in productively infected cells.
... To examine the role of ICPO in the regulation of viral gene expression during productive infection, we characterized the wild-type virus, an ICPO null mutant 7134, and several ICPO nonse[r] ... See full document
12
Reactivation of Expression from Quiescent Herpes Simplex Virus Type 1 Genomes in the Absence of Immediate-Early Protein ICP0
... ate virus stocks for superinfection studies, mutant dl1403Y, which is dl1403 with an insertion of YFP controlled by the HCMV MIEP at the TK locus, was ...nonpenetrated virus, and viral-DNA levels ... See full document
9
Long-Term Transgene Expression in Mice Infected with a Herpes Simplex Virus Type 1 Mutant Severely Impaired for Immediate-Early Gene Expression
... VP16 mutant (in1851), which is unable to replicate in neurons due to an insertion that disrupts the TK coding sequences (12), since the number of -galactosidase-positive neurons after inoculation with ... See full document
9
The herpes simplex virus type 1 immediate-early protein ICP0 is necessary for the efficient establishment of latent infection.
... 17 1 , as shown in ...17 1 , the results were not altered by the continuous presence of acyclovir (lane ...the gene for ICP0 do not decrease the ability of th mutant viruses to initiate viral ... See full document
9
The PK Domain of the Large Subunit of Herpes Simplex Virus Type 2 Ribonucleotide Reductase (ICP10) Is Required for Immediate-Early Gene Expression and Virus Growth
... of herpes simplex virus (HSV) ribonucleotide reductase (RR), RR1, contains a unique amino-terminal domain which has serine/threonine protein kinase (PK) ...in virus replication, we studied an ... See full document
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Identification of dominant-negative mutants of the herpes simplex virus type 1 immediate-early protein ICP0.
... Regulation of the herpes simplex virus type 1 late gamma2 glycoprotein C gene: sequences between base pairs -34 to +29 control transient expression and responsiveness to transactivation [r] ... See full document
7
Prolonged gene expression and cell survival after infection by a herpes simplex virus mutant defective in the immediate-early genes encoding ICP4, ICP27, and ICP22.
... viral gene expression (14, 52, ...viral gene expression and growth in tissue culture and in the trigeminal ganglia of mice (6, 7, ...of virus from latency in the mouse model (6, ...late ... See full document
12
Induction of herpes simplex virus type 1 immediate-early gene expression by a cellular activity expressed in Vero and NB41A3 cells after growth arrest-release.
... Previous studies have shown that a cellular activity expressed maximally in Vero cells 8 h after release from growth arrest in the G0/G1 phase of the cell cycle can enhance plaque format[r] ... See full document
12
Differential Role of Sp100 Isoforms in Interferon-Mediated Repression of Herpes Simplex Virus Type 1 Immediate-Early Protein Expression
... The 293-S cell line is deficient in Sp100 protein expression. The differential distribution of Sp100 isoforms raised the pos- sibility of functional differences among the Sp100 isoforms with respect to the ... See full document
11
Molecular Genetics of Herpes Simplex Virus VI. Characterization of a Temperature-Sensitive Mutant Defective in the Expression of All Early Viral Gene Products
... KNIPE,' WILLIAM BATTERSON,' CATHY NOSAL, BERNARD ROIZMAN,2* AND Received 14 April 1980/Accepted 19 January 1981 The herpes simplex virus 1 HFEM mutant tsB7 failed to express any detectab[r] ... See full document
9
Cytotoxicity of a replication-defective mutant of herpes simplex virus type 1.
... It is also possible that early gene expression in cells infected by HSV-1 strains which have an intact IE 3 gene contributes to the induction of CPE, particularly since IE 3-expressing s[r] ... See full document
14
Construction and properties of a mutant of herpes simplex virus type 1 with glycoprotein H coding sequences deleted.
... 25 take the view that the accumulation of virus particles at the cell surface by interaction with heparin sulfate is followed by the interaction of the virus with a saturable receptor in[r] ... See full document
8
Neurons Differentially Activate the Herpes Simplex Virus Type 1 Immediate-Early Gene ICP0 and ICP27 Promoters in Transgenic Mice
... 4. Expression of -galactosidase in neurons of the cerebral cortex in mice containing HSV-1 IE gene (ICP0 and ICP27) and late gene (gC) reporter transgenes in the absence of viral ... See full document
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