[PDF] Top 20 A deletion mutant of the latency-associated transcript of herpes simplex virus type 1 reactivates from the latent state with reduced frequency.
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A deletion mutant of the latency-associated transcript of herpes simplex virus type 1 reactivates from the latent state with reduced frequency.
... American Society for Microbiology A Deletion Mutant of the Latency-Associated Transcript of Herpes Simplex Virus Type 1 Reactivates from the Latent State with Reduced Frequency Received [r] ... See full document
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A 437-base-pair deletion at the beginning of the latency-associated transcript promoter significantly reduced adrenergically induced herpes simplex virus type 1 ocular reactivation in latently infected rabbits.
... 17Syn 1 DNA, follow- ing SalI and NotI ...isolated from the eyes of wild-type-infected ...DNA from virus isolated from 17 D S/N-in- fected ...S/N mutant (20) and therefore ... See full document
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Analysis of Protein Expression from within the Region Encoding the 2.0-Kilobase Latency-Associated Transcript of Herpes Simplex Virus Type 1
... expressed from a 2.0-kb LAT-GFP virus during either productive or latent ...expressed from within the ...expressed from viral LAT ...recombinant virus, vLAT-GFP, was produced by ... See full document
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Downstream regulatory elements increase acute and latent herpes simplex virus type 2 latency-associated transcript expression but do not influence recurrence phenotype or establishment of latency.
... (each virus has a preferred site for reactivation [20]) and that the RNA se- quences of the HSV-1 and HSV-2 LAT introns are quite dif- ferent ...The deletion of HSV-1 LAP1 did not influence ... See full document
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During Herpes Simplex Virus Type 1 Infection of Rabbits, the Ability To Express the Latency-Associated Transcript Increases Latent-Phase Transcription of Lytic Genes
... promoter deletion mutant, the HSV-1 genomes were less enriched in the repressive histone dimethyl H3 K9 than with the wild type ...the latent HSV genome in the rabbit, a ChIP experiment ... See full document
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Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene Promotes Neuronal Survival
... of latency is not yet ...also reduced the expression of viral protein in LAT promoter-positive neurons to wild-type levels ...by mutant and wild-type isolates, a subsequent study ... See full document
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Genetic Studies Exposing the Splicing Events Involved in Herpes Simplex Virus Type 1 Latency-Associated Transcript Production during Lytic and Latent Infection
... donor mutant LAT RNA was greatly underrepresented and differed in electrophoretic mo- bility from the normal 2-kb ...donor mutant virus established latency with reduced ... See full document
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Two herpes simplex virus type 1 latency-active promoters differ in their contributions to latency-associated transcript expression during lytic and latent infections.
... the virus in establishing latency. Once latency is estab- lished, LAP1 expresses LAT in order to maintain the latent state by inhibiting ICP0 protein ...that virus reactivation ... See full document
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A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation.
... tion transcript termination signal inserted at various sites along the primary transcript, we present evidence that the epineph- rine-induced reactivation phenotype resides primarily within the 5 9 region ... See full document
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Herpes Simplex Virus Type 1 Latency-Associated Transcript Expression Protects Trigeminal Ganglion Neurons from Apoptosis
... with herpes simplex virus type 1 (HSV-1), an immune response is initiated resulting in significant infiltration of CD8 ⴙ T ...the latency-associated ... See full document
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A herpes simplex virus type 1 latency-associated transcript mutant reactivates with normal kinetics from latent infection.
... Expression of herpes simplex virus type 1 latency-associated transcripts in the trigeminal ganglia of mice during acute infection and reactivation of latent infection.. Expression of her[r] ... See full document
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In vivo deletion analysis of the herpes simplex virus type 1 latency-associated transcript promoter.
... a latent infection, and thus these cell lines may vary considerably in the quantity and specificity of their transcription ...promoter mutant in three cell lines and compare the results with those obtained ... See full document
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A Herpes Simplex Virus Type 1 Latency-Associated Transcript Mutant with Increased Virulence and Reduced Spontaneous Reactivation
... derived from HSV-1 strain ...marker-rescued virus dLAT2903R, dLAT371 and its marker-rescued virus dLAT371R, and ...LAT transcript(s) made by each virus are detailed in ...LAT ... See full document
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The Latency-Associated Transcript Gene Enhances Establishment of Herpes Simplex Virus Type 1 Latency in Rabbits
... the virus (TRL, terminal repeat long; IRL, internal repeat long; IRS, internal repeat short; TRS, terminal repeat short) that bound the unique long (UL) and unique short (US) ...a deletion from LAT ... See full document
7
The herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latency.
... with mutant KOS/29 suggest that it is the transcription of the LAT locus that is ...This mutant contains a deletion of 203 bp of the basal LAT promoter that overlaps the deletion in KOS/62 by ... See full document
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The Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Enhancer/rcr Is Hyperacetylated during Latency Independently of LAT Transcription
... ing latency suggested that the process of active transcription itself, and the recruitment of histone acetyltransferases by the RNA Pol II complex, was responsible for this acetylation pro- ...a deletion of ... See full document
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Interactions between Herpesvirus Entry Mediator (TNFRSF14) and Latency-Associated Transcript during Herpes Simplex Virus 1 Latency
... the latency- reactivation cycle has been identified, suggesting that LAT regu- lates the latency-reactivation cycle by exerting its effect as an RNA molecule rather than by directing production of a ...LAT ... See full document
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The Latency-Associated Transcript Inhibits Apoptosis via Downregulation of Components of the Type I Interferon Pathway during Latent Herpes Simplex Virus 1 Ocular Infection
... and 1-bromo-2 chloropropane (BCP) as described previously ...leukemia virus (MuLV) reverse transcriptase from a high-capacity cDNA reverse transcription kit (Applied Biosystems, Foster City, CA), ... See full document
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The herpes simplex virus type 1 2.0-kilobase latency-associated transcript is a stable intron which branches at a guanosine.
... Herpes simplex virus type 1 (HSV-1) is neurotropic virus capable of forming latent infections for the lifetime of an ...During latency, transcription is ... See full document
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A Herpes Simplex Virus Type 1 Mutant Expressing a Baculovirus Inhibitor of Apoptosis Gene in Place of Latency-Associated Transcript Has a Wild-Type Reactivation Phenotype in the Mouse
... simian virus 40 (SV40) poly(A) signal (nt 488 to 1087 of pTRE) using the PCR-TOPO cloning ...the mutant dLAT-cpIAP by homologous recombination, as previously described for the construction of other ... See full document
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