[PDF] Top 20 The Effects of Deleterious Mutations on Evolution at Linked Sites
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The Effects of Deleterious Mutations on Evolution at Linked Sites
... nonsynonymous mutations within genes of ...synonymous mutations affecting codon ...synonymous sites themselves (see below) may also contribute to these patterns (Comeron and Kreitman 2002; Comeron ... See full document
18
Weak Selection and Protein Evolution
... recessive effects of newly arising ...for deleterious mutations in Drosophila; deleterious mutations of large effect tend to be recessive (large s, small h) whereas alleles of small ... See full document
20
Hypermutability in Asexuals: Investigating the Effects of Deleterious Mutations
... beneficial mutations, can be strong and rapid where genetic linkage is present, as evidenced by numerous observations in experimental microbial ...the evolution of reduced genomic mutation ...rapid ... See full document
98
Terumi Mukai and the Riddle of Deleterious Mutation Rates
... further evolution” (Haldane 1937, ...and effects of deleterious ...for mutations that are lethal when homozy- renewed interest in the problem of deleterious muta- ...ex- ... See full document
9
The Evolution of Selfing Is Accompanied by Reduced Efficacy of Selection and Purging of Deleterious Mutations
... strongly deleterious sites in the DFEs obtained from both simulated and empirical ...As deleterious mutations became more dominant, the effective strength of selection acting against them in ... See full document
40
Modes of Reproduction and the Accumulation of Deleterious Mutations With Multiplicative Fitness Effects
... of mutations but also on the reproductive ...deterministic deleterious mutations states that in large populations segregation and recombination may lead to a lower load of deleterious ... See full document
12
Dynamics and Fate of Beneficial Mutations Under Lineage Contamination by Linked Deleterious Mutations
... these mutations can influence each others’ fates and evolutionary effects as a consequence of linkage (reviewed in Gordo and Charlesworth 2001; Barton 2009; Charlesworth 2009, ...and deleterious ... See full document
14
Testing for Epistasis Between Deleterious Mutations
... which deleterious mutations interact in their effects on fitness is crucial to numerous areas in population genetics and evolutionary ...the evolution of sex and recombination may be favored ... See full document
10
The Role of Background Selection in Shaping Patterns of Molecular Evolution and Variation: Evidence from Variability on the Drosophila X Chromosome
... of deleterious mutations) is more effective on the autosomes than on the X chromosome, because of the lack of crossing over in male ...expected effects of background selection on neutral variability ... See full document
14
Deleterious Mutations and the Genetic Variance of Male Fitness Components in Mimulus guttatus
... harmful mutations may be critical to a wide reduction caused by the mutation when in homozygous range of ecological and evolutionary ...the evolution of sex, mating systems, and mate tional effects ... See full document
16
On the Average Coefficient of Dominance of Deleterious Spontaneous Mutations
... of effects of deleterious mutations (see recent ground, and the viability of heterozygotes is compared reviews by Garcı´a-Dorado et ...heterozygous effects of mutations are cerns the ... See full document
11
Joint Evolution of Dispersal and Inbreeding Load
... dominance effects of the deleterious mutants play crucial roles (W ang et ...of deleterious mutations is large enough that selection is more important than drift, inbreeding load will be ... See full document
13
The evolution of recombination rates caused by recurrent deleterious mutations
... of mutations on one particular fitness trait relates to the total fitness effect of each mutation in natural ...fitness effects requires assumptions about ... See full document
120
Epistasis and the Adaptability of an RNA Virus
... (1) mutations with varying deleterious fitness effects, (2) one or two deleterious mutations, and (3) pairs of mutations showing differences in the strength and sign of ...that ... See full document
8
The molecular chaperone dnak is a source of mutational robustness
... the deleterious effects of mutations that affect protein folding, they are also a source of mutational ...protein evolution, chaperones are able to increase a protein’s mutational robustness ... See full document
13
Evidence for Abundant Slightly Deleterious Polymorphisms in Bacterial Populations
... molecular evolution predicts that slightly deleterious mutations subject to purifying selection are widespread in natural populations, particularly those of large effective population ...segregation ... See full document
6
The Effects of Deleterious Mutations on Linked, Neutral Variation in Small Populations
... and Aquadro 1992; Aquadro et al. 1994; Charles- parameter space defined by recombination rate and the worth 1996) although the data also agree with hitch- product Nhs. We look particularly at the situations when hiking ... See full document
9
The Distribution of Fitness Effects of New Deleterious Amino Acid Mutations in Humans
... since mutations of quite strong effect have some chance of being sampled, and hence we have more information about the distribution of fitness effects for a broader spectrum of selection ...neutral ... See full document
10
Weakly Deleterious Mutations and Low Rates of Recombination Limit the Impact of Natural Selection on Bacterial Genomes
... are linked together for many generations. When many linked sites are under selection against weakly deleterious mutations, this “background selection” can reduce the effective ... See full document
10
Aging: progressive decline in fitness due to the rising deleteriome adjusted by genetic, environmental, and stochastic processes
... and mutations could accumulate in the genomes over evolutionary timescales, if these alleles and mutations show beneficial or neutral effects on fitness in early life, but are detrimental in later ... See full document
10
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