[PDF] Top 20 Evaluation of gene based association tests for analyzing rare variants using Genetic Analysis Workshop 18 data
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Evaluation of gene based association tests for analyzing rare variants using Genetic Analysis Workshop 18 data
... a gene-based approach using three strategies to group/bin the variants within each ...grouped variants that belong to the same gene and are of the same annotation type, that is, ... See full document
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Evaluation of the power and type I error of recently proposed family based tests of association for rare variants
... of rare genetic variation on common ...nucleotide rare genetic variant (SNV). Two major classes of tests, collapsing and variance components, have been proposed for testing case-control ... See full document
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Evaluation of pooled association tests for rare variant identification
... multiple rare variants in a gene. Based on our analyses for the GAW17 data, we find that no method is universally better than the ...overall evaluation of the three popular ... See full document
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Higher criticism approach to detect rare variants using whole genome sequencing data
... single-variant tests for whole genome sequencing (WGS) data, the association test for variant groups is a key approach for genetic ...weak genetic effects to be detected, the higher ... See full document
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Powerful association test combining rare variant and gene expression using family data from Genetic Analysis Workshop 19
... The rare variants here are defined as genetic variants with a minor allele frequency of less than 1 ...of analyzing one variant at a time is oftentimes underpowered for rare ... See full document
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Application of noncollapsing methods to the gene based association test: a comparison study using Genetic Analysis Workshop 18 data
... of Genetic Analysis Workshop 18 (GAW18), simulated phenotypic data, based on a real sequencing data set, were provided to the scientific community to evaluate and compare ... See full document
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Gaussian graphical models for phenotypes using pedigree data and exploratory analysis using networks with genetic and nongenetic factors based on Genetic Analysis Workshop 18 data
... points using real ...exploratory analysis of the ...graph using 20 causal variants, 21 noncausal variants, and 6 binary and quantitative phenotypes using the simulated ...causal ... See full document
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Pathway based joint effects analysis of rare genetic variants using Genetic Analysis Workshop 17 exon sequence data
... genome-wide association studies have been widely used to identify genetic risk factors for complex ...This analysis paradigm has made sig- nificant progress in many genetic ...many ... See full document
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A gene based approach for testing association of rare alleles
... Genome-wide association studies (GWAS) have been promising for identifying the underlying genetic basis of complex ...identified using this ...statistical tests used in traditional GWAS may ... See full document
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Different approaches for dealing with rare variants in family based genetic studies: application of a Genetic Analysis Workshop 17 problem
... Rare variants are becoming the new candidates in the search for genetic variants that predispose individuals to a phenotype of ...because rare variants are nearly family ...for ... See full document
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Genetic association analysis using weighted false discovery rate approach on Genetic Analysis Workshop 18 data
... genome-wide association study, association between disease trait and hundreds of thousands of genetic markers are ...throughput data to adjust for multiple hypotheses testing. For ... See full document
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Challenges and directions: an analysis of Genetic Analysis Workshop 17 data by collapsing rare variants within family data
... causal gene can be shared by more than one or two families, although this gene can have different rare risk variants in those ...tion tests fail to combine signals from different ... See full document
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Patient complexity and genotype-phenotype correlations in biliary atresia: a cross-sectional analysis
... control association tests, including 89 patients ...genome-wide gene-based association test on common genetic variants (CV) and rare copy-number-variants ... See full document
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Comparison of multilevel modeling and the family based association test for identifying genetic variants associated with systolic and diastolic blood pressure using Genetic Analysis Workshop 18 simulated data
... empirical data exhibit a hierarchical ...family-based genetic association studies ...model analysis in family-based genetic association studies, especially for ... See full document
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Detecting rare functional variants using a wavelet based test on quantitative and qualitative traits
... genome-wide association study on the Genetic Analysis Workshop 17 simulated unrelated individuals data using a multilocus score test based on wavelet transformation that ... See full document
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Accounting for relatedness in family based association studies: application to Genetic Analysis Workshop 18 data
... one based on the Balding-Nichols method [4]; (b) FaST-LMM [5], which also implements 2 methods to adjust for related- ness: one using a standard covariance matrix and one using the realized ... See full document
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Analysis of Genetic Analysis Workshop 18 data with gene based penalized regression
... kernel association test (SKAT) [7] is a general- ized version of C-alpha that allows for variant weights; its successor, SKAT-O [8], optimally combines SKAT with a burden ...gle gene, ignoring information ... See full document
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A multistep approach to single nucleotide polymorphism–set analysis: an evaluation of power and type I error of gene based tests of association after pathway based association tests
... for data analysis, and Dordt College and its Summer Research Program in Statistical Genetics for their continued ...sequence data were provided by the Type 2 Diabetes Genetic Exploration by ... See full document
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Evaluation of association tests for rare variants using simulated data sets in the Genetic Analysis Workshop 17 data
... four association tests for rare variants — the combined multivariate and collapsing (CMC) method, two weighted-sum methods, and a variable threshold method — by applying them to the simulated ... See full document
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Gene based analysis of rare and common variants to determine association with blood pressure
... the Genetic Determinants of Chronic Diseases, Department of Clinical Epidemiology and Biostatistics, McMaster ...sequence data were provided by the T2D-GENES Consortium, which is supported by NIH grants U01 ... See full document
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