[PDF] Top 20 Evolution of Mutation Rates in Rapidly Adapting Asexual Populations

... the mutation rate will evolve toward a stable point at which neither mutator nor antimutator alleles are ...the mutation rates in the opposite ... See full document

... the mutation spectra observed in our short-term evolution experiments were considerably less influenced by selection than those encountered in either longer-term evolution experiments, or viruses ... See full document

... HE evolution of the genetic system has been the was first observed in bacteria and termed periodic selection subject of much theoretical research, ever since (Atwood et ...the evolution of dominance. ... See full document

... of fixation for an allele conditional on it arising in the ith-ranked ancestral individual. Probabilities are for haploid populations of size N. The table reflects the fact that while the mean probability of ... See full document

... on mutation rate with only two populations suggests that a variety of interesting phenomena may appear in such ...the evolution of mutation rates in such ... See full document

... deleterious mutation rate at equilibrium between indirect selection generated by deleterious alleles and the cost of replication fidelity, and show that these expressions correctly predict the outcome of ... See full document

... Much population genetics and evolution theory depends on knowledge of genomic mutation rates and distributions of mutation effects for fitness, but most information comes[r] ... See full document

... Upon the reviewer's comment, we also examined the effect of recombination. Recombination was implemented in the model by introducing a recombination step, in which every molecule that does not form a complex has the ... See full document

... ABSTRACT The accumulation of beneficial mutations on competing genetic backgrounds in rapidly adapting populations has a striking impact on evolutionary dynamics. This effect, known as clonal ... See full document

... double-mutator populations at the initial and final time point to estimate the rate of mutation to nalidixic ...the mutation rate to nalidixic acid is a reliable proxy for the genomic mutation ... See full document

... are rapidly amplified by selection and dramatically alter the evolution of the ...of mutation and selection, it is possible that beneficial and deleterious muta- tions both play an important role in ... See full document

... automictic populations still suffer from the lack of recombination and hence long- term consequences such as the accumulation of deleterious mutations through Muller’s ratchet or reduced rates of adap- ... See full document

... transmission rates between individuals, TEs should either accumulate in asexual populations to the point of lineage extinction or be completely elimi- nated (A rkhipova and M eselson 2000, 2005a; W ... See full document

... adaptive evolution in linked genomes, which integrates interference interactions between multiple bene fi cial and deleterious mutations into a unified ...fixation rates of these mutations, as well as the ... See full document

... in asexual populations and in populations reproducing sexually at any uniform recombination ...at mutation-selection balance. These results are demonstrated in populations ... See full document

... the evolution of the fre- quency of a subpopulation emerges naturally in this more general analysis and indeed correspond to the universal limit of asymptotically large populations (Fisher ...large ... See full document

... Rammohan Mallipeddi and Minho Lee in the same year proposed ESMDE [20], an evolving surrogate (substitute) model-based DE. In ESMDE, based on the current population a surrogate model is created and this is used for ... See full document

... The mutation rates listed, in table 2 may now be compared with the fre- quencies of the chromosomes in natural populations which are lethal or semi- lethal when homozy[r] ... See full document

... The origin of the recombination-activating genes (RAGs) is considered to be a foundation hallmark for adaptive immunity, characterised by the presence of antigen receptor genes that provide the ability to recognise and ... See full document

... Figure 6.—Assuming the ratio of beneficial to deleterious mutations, k, is fixed and small, the long-term average rate of fitness improvement C in an asexual population is maximized when the deleterious ... See full document