[PDF] Top 20 FORMULATION AND EVALUATION OF CONTROLLED RELEASE TABLETS OF LAMIVUDINE BY 22 FACTORIAL DESIGN

... oral controlled release tablets of Lamivudine employing a combination of hydrophilic polymer, HPMC K 100M and hydrophobic polymer, ethyl cellulose using 2 2 factorial ...drug ... See full document

... drugs. Tablets are the most popular oral formulations available in the market and are preferred by patients and physicians ...[1]. Controlled release (CR) tablet formulations are preferred for such ... See full document

... CONCLUSION: Controlled release floating tablets of lamivudine formulated by using HPMC K4 M at a concentration of 40% w/w and sodium bicarbonate at 20% exhibited a floating lag time of less ... See full document

... the formulation at 40°C ± 2°C and 75% RH ± 5% RH was conducted for the 3 months, which includes the testing of parameters like identification of physical characters, identified by FTIR studies, dissolution profile ... See full document

... formulation design and in vitro/in vivo investigation of Once-daily propranolol extended-release tablet dosage form, it is composed of three formulation variables: the content of HPMC (X1); ... See full document

... of tablets and suspension have to be administered multiple times a day, leading to drawbacks such as poor patient compliance and poor control over therapy due to fluctuating plasma drug ...daily formulation ... See full document

... (3) Lamivudine requires multiple daily drug dosage in order to maintain adequate plasma ...making controlled release ...on Lamivudine ER formulations, some of them are, mucoadhesive ... See full document

... sustained release tablets were carried out in USP XXIII type-II dissolution test apparatus (Paddle type) using 900 ml of ...drug release by measuring the absorbance at 254 nm using UV Visible ... See full document

... metabolite, Lamivudine triphosphate ...monophosphate, Lamivudine is a synthetic nucleoside ...immediate release dosage form allows a manufacturer to extend market exclusivity, while offering patients ... See full document

... The in vitro dissolution 11 studies were carried out using USP apparatus type II (Lab India 8000) at 75 rpm. For the first 2 h the dissolution medium was 0.1N HCl (pH 1.2) and phosphate buffer pH 6.8 from 3-8 h (900 ml), ... See full document

... factorial design to achieve NLT 85% dissolution in 10 ...Irbesartan tablets as per 2 2 factorial design, βCD and Crospovidone are considered as the two ...2 factorial ... See full document

... delivery design for other ...oral controlled drug delivery systems (OCDDS) relay on diffusion, dissolution, or combination of both mechanisms, to release the drug in a controlled manner to the ... See full document

... no. 22 and then evaluated for angle of repose, bulk density, tapped density, bulkiness, compressibility index and hausner ...into tablets weighing 500 mg using 12 mm round flat faced punches in a rotary ... See full document

... all tablets are the most popular oral formulations available and preferred by the patients and physicians ...Hence, Controlled release (CR) tablet formulations are much desirable and preferred for ... See full document

... the design of dosage forms for oral controlled release administration, and hydrophilic polymers matrix systems are widely used because of their flexibility to provide a desirable drug release ... See full document

... mg) tablets were prepared by direct compression method as per the formula given in Table ...Micromeritic evaluation of the blends was made by determining angle of repose (θ) and compressibility index ... See full document

... Drug release studies: The drug release from the prepared controlled release floating tablets of lamivudine formulations were tested in 900ml of ...for lamivudine content ... See full document

... al., Controlled-release (CR) medications offer many clinical and convenience advantages for patients as compared to immediate-release (IR) ... See full document

... Pre formulation characterization of the pure drug was performed for comparing the data with different developed formulations (F1 to F12), obtained from the analysis of formulation of ... See full document

... prepared tablets: The results of physical evaluation of tablets were given in Table ...The tablets of different batches were found uniform with respect to hardness within the range of ... See full document