[PDF] Top 20 FORMULATION & EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF SIMVASTATIN USING SYNTHETIC POLYMERS

... formulate sustained release matrix tablet of ...the release of Simvastatin from polymer matrices PVP K-30 and PEG 4000 ...separately. Simvastatin is a anti- hyperlipidemic ... See full document

... a matrix system the drug is dispersed as solid particles within a porous matrix formed of a hydrophobic polymer (such as wax, polyethylene, polypropylene, and ethylcellulose) or hydrophilic polymer (such as ... See full document

... Different tablets formulations were prepared by direct compression and wet granulation technique. Direct compression method: All powders were passed through 60 mesh. Required quantities of drug and polymers were ... See full document

... develop sustained release matrix tablet of phenytoin sodium using eudragit-RL100,eudragit- RS100, HPMC-E15, ethyl cellulose (N-14),Chitosan and HPMC as release controlling factor ... See full document

... was used as dissolution medium for first 2 hrs and (pH 7.4) phosphate buffer for up to 24 hrs the test of the period as dissolution medium. The paddle was adjusted at 75 rpm and the temperature of 37±0.5ºC was maintained ... See full document

... formulate sustained release mucoadhesive matrix tablet of antiviral drug ...Lamivudine matrix tablet was developed to prolong drug release, to enhance the bioavailability, ... See full document

... by using sodium alginate as hydrophilic carrier in various polymer interactions were observed in FT-IR ...drug release profile of Aceclofenac from microbeads was examined in simulated gastric fluid ...The ... See full document

... 0.999) indicate the best fitted models for the respective formulations (Table 5). The dissolution data of F-6 was the best fitted in Zero order and Korsemeyer models (Table 6 and Figure 5, 8) where swelling and erosion ... See full document

... the melting point of Losartan Potassium .In all the DSC spectrums the characteristic drug melting point was observed with slight changes in terms of broadening or shifting towards lower temperature. This could be due to ... See full document

... Extended release formulations are better over conventional multidose delivery system, particularly for long- term therapeutic effect and for the treatment of chronic ...immediate release of the drug and the ... See full document

... of sustained release tablets: Sustained release matrix tablets of Atorvastatin Calcium were prepared by direct compression technique using natural polymers (Xanthan gum, ... See full document

... Ranolazine SR tablets, developed by Kollidon SR, microcrystalline cellulose and magnesium stearate. In which kollidon SR is a polyvinyl acetate based excipient for directly compressible matrix tablets. It required ... See full document

... drug release at desired site within the time before GRDFs left the stomach and upper part of the GIT, has provoked a great deal of increased interest in the formulation of such drug as Floating drug ... See full document

... in-vitro release profile and drug ...that formulation was ...that formulation of sustained release tablet of Rifampicin containing Guar gum ...optimized formulation of ... See full document

... develop matrix tablet of Metformin Hydrochloride for sustained release using Hydrophilic synthetic polymer (HPMC K100M) and Natural polymer (Guar gum) as the retardant ... See full document

... These polymers were hydroxypropylmethylcellulose (HPMC), Sodium carboxymethylcellulose ...drug release involved a combination of bothdiffusion and polymer-chain relaxation ...to release 50%of MCP ... See full document

... performed using Fourier-transform (FT-IR) ...taken using KBr pressed pellet method ...[7] Sustained drug action pre determined rate by maintaining a relatively constant [8] The effective drug level ... See full document

... controlled release matrix tablets of lamivudine having different proportion of Guar gum (retardant polymer) and studied the effect of formulation factor such as polymer proportion on the in- vitro ... See full document

... oral formulation would be a significant advantage for patient compliance accompanied by minimization of the drug side effects as a result of reduction in the drug blood concentration fluctuations, especially in ... See full document

... Sustained release drug delivery systems (SRDDS) are designed to increase the concentration of in the systemic circulation for prolonged period of time 2 ...involves formulation and evaluation ... See full document