[PDF] Top 20  FORMULATION AND IN VITRO EVALUATION OF STOMACH SPECIFIC FLOATING MICROSPHERES OF SIMVASTATIN

... the stomach specific floating microspheres of ...simvastatin. Simvastatin microspheres were prepared by ionotropic gelation method using polymers such as sodium alginate, ... See full document

... Simvastatin is HMG-CoA reductase inhibitor used as an anti-hyperlipidemic drug. For its prokinetic action oral bioavailability of 5%, due to extensive presystemic metabolism. Therefore, it is advantageous to ... See full document

... successful formulation depends only on suitable selection of ...for microspheres preparation were studied by FTIR (Fourier transform infra-red spectroscopy) to know the drug – polymer ... See full document

... the formulation made with higher PVA and Eudragit RS100 levels and lower EC level exhibited a high percentage cumulative drug ...Hollow microspheres with desired parameters were accomplished by desirability ... See full document

... a specific region of the gastro intestinal tract (GI) offers numerous advantages like improved bioavailability and therapeutic efficacy, local delivery of drugs and possible reduction of dose ...as floating ... See full document

... form microspheres, it has been widely used in sustained drug release ...the floating microspheres preparation by ionic gelation technique and sodium bicarbonate used as gas generating agent ... See full document

... and evaluation of gastro-retentive floating drug delivery system for anti-diabetic drug metformin hydrochloride that would retain the drug in stomach and continuously release the drug in controlled ... See full document

... In vitro Dissolution studies was done as one of the most important quality control test perfor med dur ing the project period on pharmaceutical dosage forms and developed as a tool for predicting bioavailability ... See full document

... ¾ Shah S.H. et. al., (2005) Technological attempts have been made in the research and development of rate-controlled oral drug delivery systems to overcome physiological adversities, such as short gastric residence times ... See full document

... designing floating drug delivery systems (FDDS) or hydrodynamically balanced systems have a bulk density lower than gastric fluids and therefore remain floating in the stomach without affecting the ... See full document

... the stomach for a longer period of time than conventional dosage ...manner Floating drug delivery system is an approach to prolong gastric residence time, thereby targeting site-specific drug release ... See full document

... systems: Floating drug delivery systems have bulk density less than gastric fluids and so remain buoyant in the stomach without affecting gastric emptying rate for a prolonged period of ...is ... See full document

... Gastroretentive floating microsphere containing Lafutidine, a second generation histamine H 2 –receptor antagonist were prepared by ionotropic gelation technique by using sodium alginate, HPMC K4M, ethyl cellulose ... See full document

... Microsphere can be defined as "solid, approximately spherical particles ranging from 1 to 1000 µm." They are made up of polymeric, waxy, or other protective materials, i.e., biodegradable synthetic polymers and ... See full document

... Methodology: Floating microspheres of Levofloxacin were prepared by solvent evaporation ...prepared microspheres are subjected to evaluation for particle size, % buoyancy, in-vitro ... See full document

... time specific oral floating pulsatile multiparticulate system of indomethacin intended for ...by formulation of beads with blend of floating and pulsatile principles showed typical two phase ... See full document

... the floating tablets of venlafaxine hydrochloride using HPMC K 100M and Pulllulan gum as ...Developed formulation gave satisfactory results for various evaluations for tablets like hardness, weight ... See full document

... absorbed from the gastrointestinal tract (GIT) and having a short half life are eliminated quickly from the blood circulation eg. Glipizide . To avoid this problem, the oral sustained or controlled release (CR) systems ... See full document

... the stomach for a longer period of time than conventional dosage forms ...include floating drug delivery systems, also known as hydrodynamically balanced systems, swelling and expanding systems, polymeric ... See full document

... efficiency. This factor as well as other factors such as repetitive dosing and unpredictable absorption leads to the concept of controlled drug delivery systems. The objective of controlled release drug delivery includes ... See full document