[PDF] Top 20 Genetic association analysis based on a joint model of gene expression and blood pressure
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Genetic association analysis based on a joint model of gene expression and blood pressure
... that association tests of common variants in copula models have higher power when there is a high correlation between the 2 ...rare-variant association tests when incorporating multilevel biological ...a ... See full document
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ASSOCIATION OF CYP3A5 (6986G>A) GENE POLYMORPHSIM WITH ESSENTIAL HYPERTENSION AND BLOOD PRESSURE
... the genetic susceptibility to it could be an outcome of the inherited differences in the capacity of sodium ...of blood pressure (BP) and thus, may serve as a potential risk factor for the ... See full document
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Comparison of multilevel modeling and the family based association test for identifying genetic variants associated with systolic and diastolic blood pressure using Genetic Analysis Workshop 18 simulated data
... rare genetic variants. In contrast, family-based association studies are particularly useful for identifying rare-variant ...family-based genetic association ...multilevel ... See full document
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Bivariate genetic association analysis of systolic and diastolic blood pressure by copula models
... to model the bivari- ate distribution of SBP and DBP with copulas and con- duct appropriate inference for genetic ...single gene, and crude estimates of computation time suggest that it is feasible ... See full document
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Rare genetic variant analysis on blood pressure in related samples
... 8 gene regions ( CASZ1, MTHFR, ULK4, PLE- KHA7, CSK, CSK-ULK3, PLCD3, ZNF652 ) that were pre- viously reported to be associated with either SBP or DBP ...variant analysis and rare- variant analysis ... See full document
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Genetic association analysis of coronary heart disease by profiling gene environment interaction based on latent components in longitudinal endophenotypes
... from Genetic Analy- sis Workshop (GAW) 16 Problem 2 are ideal for testing this approach to identify genetic variants that interact with the environment in the development of ...diastolic blood ... See full document
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Rare variant analysis of blood pressure phenotypes in the Genetic Analysis Workshop 18 whole genome sequencing data using sequence kernel association test
... diastolic blood pressure phenotypes of 142 unrelated individuals in the Genetic Analysis Workshop 18 data, we investigated whether performance of SKAT also depends on the weighting ...file ... See full document
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Bivariate linear mixed model analysis to test joint associations of genetic variants on systolic and diastolic blood pressure
... data analysis as we have a number of limitations in this study, including small sample size, missing observa- tions, uncertainty about the underlying genetic model, selection of an appropriate ... See full document
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Pathway based analysis of rare and common variants to test for association with blood pressure
... the Genetic Determinants of Chronic Diseases, Department of Clinical Epide- miology and Biostatistics, McMaster ...other genetic and phenotypic data for GAW18 were provided by the San Antonio Family Heart ... See full document
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Gene based analysis of rare and common variants to determine association with blood pressure
... The association tests (TOW and VW-TOW) were applied to each genetic region for SBP, DBP, and mean arterial pressure (MAP) on chromosome ...value, based on 10,000 permuta- tions for each ... See full document
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Joint analysis of multiple blood pressure phenotypes in GAW19 data by using a multivariate rare variant association test
... within gene CYP4A22, which was previously reported to be associated with es- sential hypertension [13, ...to gene APOC4, which is asso- ciated with coronary artery disease ...Comparing gene- ... See full document
5
Review and Upgrade of a Bulk Flow Model for the Analysis of Honeycomb Gas Seals Based on New High Pressure Experimental Data
... flow model with two control volumes, devised by Kleynhans and Childs [4] and Kleynhans [5] is an evolution of the bulk flow model used by Nelson [9] for smooth annular ... See full document
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Model based cluster analysis of microarray gene expression data
... that model-based clustering is a powerful method that is useful in analyzing gene-expression ...changed expression whereas clusters 2 and 3 consist of genes without expression ... See full document
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Effect of eprosartan-based therapy on systolic blood pressure and total cardiovascular risk in a large international population: preliminary report of the observational POWER study
... Cardiovascular risk status, as represented by mean SCORE values, improved substantially during the period of treatment and observation in POWER. In the absence of structured interventions against other major cardiovas- ... See full document
6
Polymorphisms in the SNCA Gene: Association with the Risk of Development of the Sporadic Form of Parkinson’s Disease and the Level of SNCA Gene Expression in Peripheral Blood of Patients from Russia
... (SNCA) gene is one of the most studied genes involved in the patho- genesis of ...a genetic analysis of promoter and intron single-nucleotide polymorphisms (SNPs) in the SNCA ...the ... See full document
7
Impact of baseline blood pressure on the magnitude of blood pressure lowering by nifedipine gastrointestinal therapeutic system: refreshing the Wilder’s principle
... This single-center, single-group, prospective, phase IV clinical trial enrolled 138 newly diagnosed hypertension patients. Hypertension diagnosis had to be confirmed by 24-hour ambulatory BP monitoring with SunTech’s ... See full document
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Uromodulin gene variants and their association with renal function and blood pressure in cats: a pilot study: UMOD blood pressure cats
... (2016), Uromodulin gene variants and their association with renal function and blood pressure in cats: a pilot study.. This article may be used for non-commercial purposes in accordance[r] ... See full document
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A robust blood gene expression-based prognostic model for castration-resistant prostate cancer
... the gene ex- pression level of TMEM66 (overexpressed in T cells) and lymphocyte count (Additional file 1: Figure S6A, Pearson ’ s correlation coefficient = ...TMEM66 gene expression level predicted ... See full document
15
Testing gene environment interactions in gene based association studies
... our analysis, we tested three kernel functions on a subset of genes (one gene at a time) and found that the quadratic and Gaussian kernels produced consistent results but that the quadratic kernel was com- ... See full document
6
Association between blood lead and blood pressure: a population-based study in Brazilian adults
... constructed based on a priori knowledge and biologic association with blood pressure (age, sex, antihypertensive medication use and blood lead log ...the model in two separated ... See full document
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