[PDF] Top 20 A herpes simplex virus type 1 latency-associated transcript mutant reactivates with normal kinetics from latent infection.
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A herpes simplex virus type 1 latency-associated transcript mutant reactivates with normal kinetics from latent infection.
... Expression of herpes simplex virus type 1 latency-associated transcripts in the trigeminal ganglia of mice during acute infection and reactivation of latent infection.. Expression of her[r] ... See full document
10
The Latency-Associated Transcript Inhibits Apoptosis via Downregulation of Components of the Type I Interferon Pathway during Latent Herpes Simplex Virus 1 Ocular Infection
... the type I IFN pathway during the lytic cycle (43). A study from the Jones laboratory showed that LAT delays several IFN- ␣ subtypes, including IFN- ␣ 1, IFN- ␣ 4, IFN- ␣ 5, IFN- ␣ 6, and IFN- ␣ 14, ... See full document
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Herpes Simplex Virus Type 1 Latency-Associated Transcript Expression Protects Trigeminal Ganglion Neurons from Apoptosis
... Upon infection of murine trigeminal ganglia with herpes simplex virus type 1 (HSV-1), an immune response is initiated resulting in significant infiltration of CD8 ⴙ T ... See full document
7
Detection of herpes simplex virus type 1 latency-associated transcript expression in trigeminal ganglia by in situ reverse transcriptase PCR.
... of herpes simplex virus type 1 (HSV-1) infection is the ability of the virus to establish a lifelong latent state in neurons of the sensory ganglia (13, ... See full document
5
Two herpes simplex virus type 1 latency-active promoters differ in their contributions to latency-associated transcript expression during lytic and latent infections.
... lytic infection, thereby assist- ing the virus in establishing ...Once latency is estab- lished, LAP1 expresses LAT in order to maintain the latent state by inhibiting ICP0 protein ...that ... See full document
10
Genetic Studies Exposing the Splicing Events Involved in Herpes Simplex Virus Type 1 Latency-Associated Transcript Production during Lytic and Latent Infection
... donor mutant LAT RNA was greatly underrepresented and differed in electrophoretic mo- bility from the normal 2-kb ...donor mutant virus established latency with reduced ... See full document
11
Tissue-Specific Splicing of the Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Intron in LAT Transgenic Mice
... and latent HSV-1 infections in vivo ...Following infection with wild-type HSV-1, no significant difference in establish- ment of latency between the transgenic and nontransgenic ... See full document
10
During Herpes Simplex Virus Type 1 Infection of Rabbits, the Ability To Express the Latency-Associated Transcript Increases Latent-Phase Transcription of Lytic Genes
... wild-type virus, the HSV-1 genome’s lytic gene promot- ers become associated with dimethyl histone H3 K9, a marker of transcriptional repression, during establishment of latency, while ... See full document
5
Downstream regulatory elements increase acute and latent herpes simplex virus type 2 latency-associated transcript expression but do not influence recurrence phenotype or establishment of latency.
... (each virus has a preferred site for reactivation [20]) and that the RNA se- quences of the HSV-1 and HSV-2 LAT introns are quite dif- ferent ...the virus as a reporter (10). While the LAP1 regions ... See full document
7
The herpes simplex virus type 1 2.0-kilobase latency-associated transcript is a stable intron which branches at a guanosine.
... Herpes simplex virus type 1 (HSV-1) is neurotropic virus capable of forming latent infections for the lifetime of an ...During latency, transcription is ... See full document
10
Analysis of Protein Expression from within the Region Encoding the 2.0-Kilobase Latency-Associated Transcript of Herpes Simplex Virus Type 1
... productive infection and latency, while a second promoter was active in tissue culture cells, ...productive infection (5). Which- ever the case, transcripts originating from LAP1 in the ... See full document
14
Interactions between Herpesvirus Entry Mediator (TNFRSF14) and Latency-Associated Transcript during Herpes Simplex Virus 1 Latency
... he herpes simplex virus 1 (HSV-1) infects its human host through multiple routes, stimulating strong immune re- sponses that resolve the acute infection but prove unable to pre- ... See full document
11
A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation.
... LAT transcript and indicate that the reactivation phe- notype resides at the 5 * ...(Fig. 1). These poly(A) inser- tions allowed us to truncate the LAT transcript at the site of the poly(A) insertion ... See full document
11
A deletion mutant of the latency-associated transcript of herpes simplex virus type 1 reactivates from the latent state with reduced frequency.
... American Society for Microbiology A Deletion Mutant of the Latency-Associated Transcript of Herpes Simplex Virus Type 1 Reactivates from the Latent State with Reduced Frequency Received [r] ... See full document
8
Gender Influences Herpes Simplex Virus Type 1 Infection in Normal and Gamma Interferon-Mutant Mice
... biological latency) ...the latent stage, a suggested predictor of HSV reactivation (23, 25, 29), may be greater in male ...of infection in male and female mice ...reactivation from molecular ... See full document
6
A Herpes Simplex Virus Type 1 Mutant Expressing a Baculovirus Inhibitor of Apoptosis Gene in Place of Latency-Associated Transcript Has a Wild-Type Reactivation Phenotype in the Mouse
... blocking virus-induced apoptosis in neurons, we propose two additional potential mechanisms that we feel are worthy of ...trigger from killing the neuron prior to the completion of ...differs from ... See full document
10
A Herpes Simplex Virus Type 1 Latency-Associated Transcript Mutant with Increased Virulence and Reduced Spontaneous Reactivation
... derived from HSV-1 strain ...marker-rescued virus dLAT2903R, dLAT371 and its marker-rescued virus dLAT371R, and ...LAT transcript(s) made by each virus are detailed in ...LAT ... See full document
10
The herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latency.
... establishes latent infections in dorsal root ganglia neurons ef- ficiently as measured by activity from the LAT promoter, and the mutant reactivates like the wild type in vivo in this ... See full document
9
The Latency-Associated Transcript Gene Enhances Establishment of Herpes Simplex Virus Type 1 Latency in Rabbits
... the virus (TRL, terminal repeat long; IRL, internal repeat long; IRS, internal repeat short; TRS, terminal repeat short) that bound the unique long (UL) and unique short (US) ...deletion from LAT ... See full document
7
Evidence that two latency-associated transcripts of herpes simplex virus type 1 are nonlinear.
... establish latent infections in their natural hosts (reviewed in reference ...productive infection near the portal of entry, human herpes simplex virus type 1 ... See full document
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