[PDF] Top 20 Herpes simplex viruses with mutations in the gene encoding ICP0 are defective in gene expression.
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Herpes simplex viruses with mutations in the gene encoding ICP0 are defective in gene expression.
... 2916-2927 0022-538X/92/052916-12$02.00/0 Copyright © 1992, American Society for Microbiology Herpes Simplex Viruses with Mutations in the Gene Encoding ICPO Are Defective in Gene Express[r] ... See full document
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Deletion of the Herpes Simplex Virus VP22-Encoding Gene (UL49) Alters the Expression, Localization, and Virion Incorporation of ICP0
... of ICP0 in either cell type infected with WT or ⌬ 22 virus ...later, ICP0 had undergone a dramatic translocation from the nucleus to the cytoplasm in both infections ...the ICP0 pattern exhibited in ... See full document
11
Mutational analysis of the herpes simplex virus type 1 ICP0 C3HC4 zinc ring finger reveals a requirement for ICP0 in the expression of the essential alpha27 gene.
... DNAs encoding the indicated wild-type or mutant form of ICP0, as described ...of ICP0 was performed with polyclonal antibody CLU7 (43), diluted 1:200 in ... See full document
13
Mutations Inactivating Herpes Simplex Virus 1 MicroRNA miR-H2 Do Not Detectably Increase ICP0 Gene Expression in Infected Cultured Cells or Mouse Trigeminal Ganglia
... miR-H2 expression (Fig. 2D). To eliminate any effect on ICP0 expression due to miR-H2 expression, we employed NoDice cells, which lack Dicer and are derived from 293T cells ...the ... See full document
17
Cellular Transcriptional Coactivator RanBP10 and Herpes Simplex Virus 1 ICP0 Interact and Synergistically Promote Viral Gene Expression and Replication
... erpes simplex virus 1 (HSV-1) has more than 80 different genes that fall into three major classes, designated immediate early (IE) or ␣ , early (E) or  , and late (L) or ␥ , which are ex- pressed in a regulated ... See full document
14
Efficient Activation of Viral Genomes by Levels of Herpes Simplex Virus ICP0 Insufficient To Affect Cellular Gene Expression or Cell Survival
... of ICP0 expression from AdS.11E4(ICP0) and ef- fect on transgene ...the expression of undeleted IE genes from HSV-1 IE mutant viruses is increased relative to wt ...such viruses ... See full document
13
Overexpression of the Ubiquitin-Specific Protease 7 Resulting from Transfection or Mutations in the ICP0 Binding Site Accelerates Rather than Depresses Herpes Simplex Virus 1 Gene Expression
... with ICP0 and that mutations in ICP0 at residues 620 to 626 abolished this inter- action (1, ...to ICP0 coprecipitated the Flag- tagged USP7 from wild-type virus-infected cells ... See full document
8
Prolonged gene expression and cell survival after infection by a herpes simplex virus mutant defective in the immediate-early genes encoding ICP4, ICP27, and ICP22.
... viral gene expression (14, 52, 73). ICP0 will activate most test promoters in transient assays (16, 18, 47, 53) and has been found to elevate levels of viral gene expression and growth ... See full document
12
Phosphorylation Site Mutations Affect Herpes Simplex Virus Type 1 ICP0 Function
... of ICP0 is a dynamic process (1, 80), the role of phos- phorylation in ICP0 function, the location of specific phos- phorylation sites on ICP0, and the kinases that phosphorylate ICP0 are ... See full document
12
Epigenetic Modulation of Gene Expression from Quiescent Herpes Simplex Virus Genomes
... mutant defective for all five immediate- early (IE) ...supplying ICP0 in trans. d106 expresses ICP0 and the GFP transgene but none of the other IE proteins ...The expression of ICP0 ... See full document
11
Mutational analysis of ICP0R, a transrepressor protein created by alternative splicing of the ICP0 gene of herpes simplex virus type 1.
... that ICP0 behaves as a potent transactivator in transfection assays: it can activate a wide variety of promoters in a manner that is independent of specific promoter elements (11, 22, 36, 40, 41, 43, 46, ... See full document
11
Δγ134.5 Herpes Simplex Viruses Encoding Human Cytomegalovirus IRS1 or TRS1 Induce Interferon Regulatory Factor 3 Phosphorylation and an Interferon-Stimulated Gene Response
... Host pattern recognition proteins bind unique viral products (double-stranded RNA [dsRNA] and cytosolic DNA) produced during infection and activate IFN signaling pathways in the cell (14). Ultimately, these signaling ... See full document
5
Point mutations in the herpes simplex virus type 1 Vmw110 RING finger helix affect activation of gene expression, viral growth,
... IE gene products have significant or essential roles in the regulation of lytic viral gene ...IE gene 1 (IE-1) (Vmw110 or ICP0) appears to be involved in both lytic growth and latency and is ... See full document
7
ICP27 Phosphorylation Site Mutants Are Defective in Herpes Simplex Virus 1 Replication and Gene Expression
... Herpes simplex virus 1 (HSV-1) protein ICP27 is a multifunctional regulatory protein that is posttransla- tionally modified by phosphorylation during viral ...site mutations at each of the three ... See full document
12
ICP0 Gene Expression Is a Herpes Simplex Virus Type 1 Apoptotic Trigger
... That herpes simplex virus type 1 (HSV-1) induces apoptosis but then prevents its killing of infected cells is ...wild-type viruses do not result in the induction of apoptosis ...(IE) gene ... See full document
12
Perturbation of Cell Cycle Progression and Cellular Gene Expression as a Function of Herpes Simplex Virus ICP0
... the expression ICP0 can have profound effects on the metabolism and survival of ...expressing ICP0 can remain metabolically active for prolonged periods of time, they are growth arrested and ... See full document
11
A cellular function can enhance gene expression and plating efficiency of a mutant defective in the gene for ICP0, a transactivating protein of herpes simplex virus type 1.
... In an attempt to determine whether the growth status of cells in the monolayer affects the ability of ICPO mutants to initiate plaque formation, the plating efficiencies and abilities of[r] ... See full document
13
Uncoupling Uncoating of Herpes Simplex Virus Genomes from Their Nuclear Import and Gene Expression
... [58]), ICP0 (MAb 11060 [22]), ICP8 (ATCC HB-8180; Rockville, MD [83]), vaccinia virus protein p35 (MAb H5R [76]), tubulin (MAb DM1A; Sigma-Aldrich, Sch- nelldorf, Germany), vimentin (MAb 7A3 [39]), actin (MAb ... See full document
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Expression of herpes simplex virus type 1 DNA polymerase gene by in vitro translation and effects of gene deletions on activity.
... The in vitro translated pol gene product was enzymatically active, with salt resistance and sensitivity to acyclovir triphosphate, similar to the enzyme activity in crude extracts of her[r] ... See full document
9
Expression of the herpes simplex virus type 1 glycoprotein C gene requires sequences in the 5' noncoding region of the gene.
... In previous studies using recombinant viruses, we demonstrated that sequences between -1350 and +30 relative to the start of gC transcription regulate 13-Gal as a viral late gene and tha[r] ... See full document
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