[PDF] Top 20 Hypertonic Saline in Bronchiolitis and Type I Error: A Trial Sequential Analysis

... cohort that we did not attempt to resolve through sensitivity or subgroup analysis. However, a relative strength of TSA is the explicit incorporation of study heterogeneity adjustments into the analysis. ... See full document

... by trial sequential analyses (TSA) ...(interim analysis) for meta-analyses that widens the confidence intervals in case data are too sparse to draw firm conclusions (repetitive ...a type ... See full document

... When initial trials for nebulized HS delivery appeared in the literature, there was hope that it would be used to speed recovery time and shorten the length of stay (LOS) [5]. Since then, there has been extensive ... See full document

... meta- analysis ought to incorporate the heterogeneity variance (between trial variance) [1, 7, ...of type I error (α) of 5% and type II error (β) of 20% are applied ... See full document

... Methods: Searches to January 2015 involved: Cochrane Central Register of Controlled Trials; Ovid MEDLINE; Embase; Google Scholar; Web of Science; and, a variety of trials registers. We hand searched Chest, Paediatrics ... See full document

... clinical trial study conducted in 2011-2012 on 70 referring patients with acute viral bronchio- ...predetermined error in the study were excluded from the ...acute bronchiolitis de- veloped based on ... See full document

... the analysis of risk factors of secondary bacterial infections such as bacteremia and urosepsis in children with ...with bronchiolitis and 261 control ...with bronchiolitis developed bacteremia when ... See full document

... [9]. Hypertonic saline (3 %) is a new agent that has been found to be promising in recent studies ...of hypertonic saline (3, 6 or 7 ...of bronchiolitis in our practice and an ... See full document

... Clinical score is generally considered a relatively objective measure to assess the severity of illness. Eleven inpatient trials used bronchiolitis severity scores as the efficacy outcome, but only 5 trials that ... See full document

... reason for use of hyperosmolar agents are collected. The surgical site, operation time, type and amount of hyperosmolar agents used during 24 h before the study drug infusion are recorded. Acute Physiology and ... See full document

... The trial randomised 317 infants between 26 October 2011 and 23 December 2013, when it closed having reached full accrual, with 158 patients allocated to the nebulised 3% HS group and 159 allocated to usual care ( ... See full document

... characteristics (Table 1). Of subjects with a race “ Other, ” most parents/ guardians identi fi ed the patient as Hispanic. Eighty of 190 patients who completed the study quali fi ed as moderately ill based solely on RDAI ... See full document

... The treating clinician in the ED con- tacted the principal investigator who enrolled the participants within an hour of an eligible patient ’ s arrival. Care- giver consent was obtained before ad- ministration of inhaled ... See full document

... presenting to the ED until ready to discharge (CS # 6). Additionally, 2 secondary outcomes were measured: admission rate (AR) and CS improve- ment between the 2 treatment groups. Analysis of data were carried out ... See full document

... Hemorrhage and sepsis often initiate a systemic inflammatory response that is accompanied by organ dysfunction, most commonly acute lung injury [41]. Neutrophil sequestration in the lung is a necessary prerequisite for ... See full document

... tonic saline may negate the beneficial effects of hyper- tonicity ...of hypertonic saline and move the effect estimate towards ...of hypertonic saline provided to intervention groups ... See full document

... Studies of humans have shown that excessive fluid therapy can lead to coagulopathy, increased acidosis, hypothermia, abdominal compartment syndrome, elevated intracranial pressure, and immunologic disorders (27, 36-38). ... See full document

... clinical trial. Power is one minus the probability of a type II error, thus giving the probability of correctly rejecting the null ...clinical trial, it is recom- mended to set the power as ... See full document

... Pediatric age are excluded.. Cases of csf rhinorrhoea, unhealed facial trauma. Patients of neurological and musculoskeletal disorders in which cases there are chances of aspiration. 2 50 patients irrespective of age and ... See full document

... isotonic saline and hypernatremia induced by infusion of hypertonic saline, circulating and excreted ANP concentrations were not elevated (Ortiz et ... See full document