[PDF] Top 20 Improved detection of enhancing and nonenhancing lesions of multiple sclerosis with magnetization transfer

... lesion detection was improved by the combined use of gadopentetate dimeglumine and magnetization transfer; and (b) to compare signal intensities of enhancing and nonenhanc- ing ... See full document

... had lesions in either one or two categories, and none had lesions from all three ...mogeneously enhancing lesions versus nonenhancing le- sions, homogeneously enhancing ... See full document

... the enhancing lesions seen on the triple-dose gadolinium images were persisting lesions seen on images obtained 1 month earlier, monthly triple-dose contrast-en- hanced MR studies may not be superior ... See full document

... Triple-dose contrast is the most sensitive MR tech- nique for detecting enhancing lesions in patients with MS. The application of an MT pulse to T1-weighted sequences after the injection of a single dose of ... See full document

... be improved to overcome these important technical limitations and make ihMT a practical tool applicable in daily clinical ...an improved spatial resolu- tion ... See full document

... matter lesions in multiple ...cortical lesions, it has not been fully optimized for visualization of white matter lesions and thus has not been used for delineating lesions in ... See full document

... focal lesions and have also been termed ‘‘dirty’’ white matter ...non-acute lesions were subdivided according to their hypointensity on T1-weighted images as isointense and mildly and markedly ...Acute ... See full document

... the enhancing lesions return to NAWM values, even though they were completely T1 isointense with surrounding ...ring-enhancing lesions that converted to isointense had higher initial and ... See full document

... both enhancing and unen- hancing MS plaques are more evident on MT T1-weighted ...Parenchymal lesions with increased free water content and long T2 relaxation times (ie, demyelineated plaques) will be ... See full document

... edematous lesions without demyelination in the white matter of guinea pigs with experimental allergic enceph- alomyelitis but that they were significantly de- creased in focal white matter lesions in ... See full document

... demyelinating lesions has reported elevated lactate during the first 6 to 10 weeks [Davie et ...inflammatory lesions, lactate production is increased as a result o f iscbaemia, where locally raised pressure ... See full document

... of magnetization transfer (MT) in MS has been reviewed recently (6), and this technique may allow the subcategorization of MS lesions into those with a very low MT ratio (demyelinated lesions) ... See full document

... active lesions and form a major imaging marker for determining response to therapy or efficacy of new drugs; much activity is taking place that is not nec- essarily defined by enhancement ...of enhancing ... See full document

... active enhancing lesions have demonstrated increases in lactate, the choline-to-creatine ratio, and mobile lipid and cholesterol peaks (27, 28, 30, ...decreased magnetization transfer ratio ... See full document

... focal lesions are the predominant pathologic feature in CIS patients, many of whom are in the early stages of ...focal lesions rather than diffuse NAWM abnormalities are the primary event in MS patients who ... See full document

... of enhancing lesions during the baseline period, a potential alternative explanation for the reduction of enhancing lesions would be "regression to the ...active lesions during the ... See full document

... and lesions are abundantly found in the white ...that lesions could involve gray matter, although ...chronic lesions, suggesting that gray matter (neu- ronal cell bodies) may ultimately suffer damage ... See full document

... From January 2010 to December 2011, a prospective, single-cen- ter, open-label experimental phase IV study was performed at Vall d’Hebron University Hospital. The study compared a single dose and cumulative double dose ... See full document

... intracortical lesions identified on MP2RAGE were often visible in retrospect on T2*GRE and/or T2*EPI (Fig 1G–I); the same was true on MP2RAGE for several lesions initially identified only on T2* (see ... See full document

... The univariate correlations between the different MR-de- rived measures and between the different MR-derived mea- sures and EDSS were assessed using the Spearman rank cor- relation coefficient. Group comparisons were ... See full document