[PDF] Top 20 Increased Expression and Immunogenicity of Sequence-Modified Human Immunodeficiency Virus Type 1 gag Gene
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Increased Expression and Immunogenicity of Sequence-Modified Human Immunodeficiency Virus Type 1 gag Gene
... current gene delivery methods such as naked-DNA and viral vectors must be improved to induce adequately robust responses for protection in primates ...the expression efficiency of encoded HIV ...of ... See full document
8
A Strongly Transdominant Mutation in the Human Immunodeficiency Virus Type 1 gag Gene Defines an Achilles Heel in the Virus Life Cycle
... protein sequence that folds into a  -hairpin structure (21, 28, 38, ...the Gag precursor ...the Gag protein does not relieve viral infectivity of the viruses containing either 5% or 10% of the Y132I ... See full document
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Ubiquitination of Human Immunodeficiency Virus Type 1 Gag Is Highly Dependent on Gag Membrane Association
... HIV-1 Gag ubiq- uitination depends on membrane ...the increased ubiquitination of HIV-1 carrying a mutation in the PTAP motif is due to the increased amount of Gag arrested in ... See full document
9
Human immunodeficiency virus type 1 infection of H9 cells induces increased glucose transporter expression.
... HIV 1 patient serum which recognizes Gag, Gag/Pol, Vpu, and Env proteins; and control nonimmune human and mouse sera as indicated ...of expression was plotted as the geometric mean of ... See full document
5
Specific binding of human immunodeficiency virus type 1 (HIV-1) Gag-derived proteins to a 5' HIV-1 genomic RNA sequence.
... A Gag fragment with deletions of the entire MA domain and either the first or the second Cys-His box as well as part of the basic region of the NC domain showed no RNA binding ac- tivity in our ...the Gag ... See full document
5
Expression of Human Immunodeficiency Virus Type 1 Gag Modulates Ligand-Induced Downregulation of EGF Receptor
... HIV-1 Gag exhibited increased EGFR-mediated sig- naling, as evidenced by hyperactivation of the ERK/MAP ki- nase ...of increased amounts of pEGFR in endosomal compartments 180 min after the ... See full document
9
X4 Human Immunodeficiency Virus Type 1 gp120 Down-Modulates Expression and Immunogenicity of Codelivered Antigens
... protein expression could result in immune ...weak immunogenicity elicited against the coimmunized antigen can be explained by the ability of gp120 to interfere directly with antigen presentation in ... See full document
10
Inactivation of the human immunodeficiency virus type 1 inhibitory elements allows Rev-independent expression of Gag and Gag/protease and particle formation.
... The gag and protease sequences generated by mutagenic oligonucleo- tides are shown in ...HXB2 sequence, and up- percase letters indicate mutations generated during ... See full document
12
Comparative Immunogenicity in Rhesus Monkeys of DNA Plasmid, Recombinant Vaccinia Virus, and Replication-Defective Adenovirus Vectors Expressing a Human Immunodeficiency Virus Type 1 gag Gene
... with human immunodeficiency virus type 1 ...a modified vaccinia virus Ankara vector, and a replication-defective adenovirus serotype 5 (Ad5) vector, each expressing the ... See full document
9
Intracellular expression of RNA transcripts complementary to the human immunodeficiency virus type 1 gag gene inhibits viral replication in human CD4+ lymphocytes.
... target sequence, the sec- ondary structure, and the expression level of the antisense ...the gag gene and to express it as part of the murine leukemia virus (MLV) long terminal repeat ... See full document
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Inhibition of human immunodeficiency virus type 1 replication by a Tat-activated, transduced interferon gene: targeted expression to human immunodeficiency virus type 1-infected cells.
... IFN gene in HIV-1-infected cells was shown in both T cells (Jurkat) and promonocytic (U937) ...cells, expression of this modified HIV-1 LTR in the absence of Tat was either unde- ... See full document
12
Methylation of Tat by PRMT6 Regulates Human Immunodeficiency Virus Type 1 Gene Expression
... We have identified HIV-1 Tat protein as a substrate for PRMT6. This is not only the first report that a HIV-1 protein is subject to arginine methylation but also the first time that Tat was identified as ... See full document
8
Spontaneous mutations in the human immunodeficiency virus type 1 gag gene that affect viral replication in the presence of cyclosporins.
... the virus that slowly appeared after 3 weeks was tested for cyclosporin effects, with the result that the virus had reacquired the wild-type, cyclosporin-sensitive replication ...revertant ... See full document
9
A Single-Nucleotide Synonymous Mutation in the gag Gene Controlling Human Immunodeficiency Virus Type 1 Virion Production
... the gag p17 gene from these seronegative cases was amplified, cloned, and sequenced for further ...FIG. 1. Results of initial screening and phylogenetic analysis of the HIV-1 gag p17 ... See full document
6
Influence of gag on Human Immunodeficiency Virus Type 1 Species-Specific Tropism
... in human cells when HIV-1 CA/CypA interactions are prevented ...with Gag for CypA binding, leading to a loss in HIV-1 infectivity in human ...are increased by CSA suggesting that ... See full document
7
Effects of Mutations in the Human Immunodeficiency Virus Type 1 gag Gene on RNA Packaging and Recombination
... infection. Virus infection was performed in the presence of Polybrene at a final concentration of 50 ...marker expression, cells were stained with phycoerythrin-conjugated anti-heat-stable antigen ... See full document
7
Expression and biochemical characterization of human immunodeficiency virus type 1 nef gene product.
... 10, which potentially affect the GTPase and GTP binding activities; iii different Nef aminoterminal sequence in the recombinant Nef protein, resulting from initiation at a putative start[r] ... See full document
8
Evidence for Gene Expression by Unintegrated Human Immunodeficiency Virus Type 1 DNA Species
... R7 virus, and levels of intracellular HIV-1 DNA and RNA species and that of extracellular virus-like particles were monitored over a 15-day ...(f) Virus-like particles released in supernatant ... See full document
9
Variability and Immunogenicity of Human Immunodeficiency Virus Type 1 p24 Gene Quasispecies
... the human immunodeficiency virus type 1 (HIV-1) gag gene, multiple quasi- species of the p24 gene coexist in HIV-1-infected ...p24 gene, with ... See full document
7
Intrapatient sequence variation of the gag gene of human immunodeficiency virus type 1 plasma virions.
... of gag clones. By using reverse tran- scription and PCR amplification of gag sequences with nested primers as detailed in Materials and Methods, we obtained molecular clones of gag for each of the ... See full document
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