[PDF] Top 20 Interaction between Reverse Transcriptase and Integrase Is Required for Reverse Transcription during HIV-1 Replication
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Interaction between Reverse Transcriptase and Integrase Is Required for Reverse Transcription during HIV-1 Replication
... type 1 (HIV-1) needs to reverse transcribe its RNA genome to create a double-stranded DNA copy and then integrate this viral DNA genome into the chromosome of the host ...the ... See full document
12
Cooperation between Reverse Transcriptase and Integrase during Reverse Transcription and Formation of the Preintegrative Complex of Ty1
... that interaction between RT and IN is functional and critical for the polymerase activity of RT ...the reverse tran- scription defect of IN deletion or active site mutant in ... See full document
10
Requirement for Integrase during Reverse Transcription of Human Immunodeficiency Virus Type 1 and the Effect of Cysteine Mutations of Integrase on Its Interactions with Reverse Transcriptase
... RT-IN interaction is also confirmed by a pull-down assay with glutathione S-transferase or His tag, and the RT-binding site on IN is mapped to the C-terminal domain (27a), corroborating our results reported ...IN ... See full document
11
Interaction between Human Immunodeficiency Virus Type 1 Reverse Transcriptase and Integrase Proteins
... in reverse transcription exhibited by mutant viruses ...on HIV-1 ...Lanes 1, 5, 7, 9, 11, and 13 contained bound proteins from a control incubation of GST bound to G beads, and lanes 2 ... See full document
12
The RNA binding protein HuR does not interact directly with HIV 1 reverse transcriptase and does not affect reverse transcription in vitro
... interactions between HIV-1 RT and HuR are present in vitro up to concentrations of ~200 ...differences between these two isolates in their RNase H domains at codons 447 [N (BH10) T S (LAI)], ... See full document
7
HIV 1 Uncoating and Reverse Transcription Require eEF1A Binding to Surface Exposed Acidic Residues of the Reverse Transcriptase Thumb Domain
... IMPORTANCE HIV-1, like all viruses, requires host cell proteins for its ...key HIV-1 RT binding host protein that is important for the reverse transcription of ... See full document
20
The Cellular Antiviral Protein APOBEC3G Interacts with HIV-1 Reverse Transcriptase and Inhibits Its Function during Viral Replication
... 5B). During viral maturation and Gag/Gag-Pol proteolytic processing, A3G may be released from Gag and/or the Gag-Pol precursor and targets HIV-1 RT in the ...the interaction between A3G ... See full document
10
Human Immunodeficiency Virus Type 1 Integrase Protein Promotes Reverse Transcription through Specific Interactions with the Nucleoprotein Reverse Transcription Complex
... into HIV virions by their expression in trans as fusion partners of either Vpr or ...of reverse transcription in infected cells and that this function does not require the IN protein to be ... See full document
10
HuR interacts with human immunodeficiency virus type 1 reverse transcriptase, and modulates reverse transcription in infected cells
... was required for an optimal HIV-1 replication cycle and for both the early and late steps of reverse transcription, in ...the reverse transcription reaction ... See full document
14
Role of Integrase in Reverse Transcription of the Saccharomyces cerevisiae Retrotransposon Ty1
... Reverse transcriptase (RT) and integrase (IN) play a central role in the replication and integration of retroviral and retro- transposon genomes into the host cell ...interactions ... See full document
9
Analysis of the Contribution of Reverse Transcriptase and Integrase Proteins to Retroviral RNA Dimer Conformation
... cDNA during reverse transcrip- tion. HIV-1 DIS mutations that impair RNA dimerization have also been shown to reduce DNA synthesis around the second strand transfer step, though the mechanism ... See full document
11
Hepatitis B Virus Reverse Transcriptase and ε RNA Sequences Required for Specific Interaction In Vitro
... long-range interaction of this region of the ε with the sequences near the 3 ⬘ DR1 to facilitate template switching from ε to DR1 during minus-strand DNA synthesis ... See full document
10
Ty3 Integrase Is Required for Initiation of Reverse Transcription
... for reverse transcrip- tion initiation complex ...in reverse transcription occurs subsequent to for- mation of any genomic complexes required for ... See full document
13
Molecular Modeling of Potential Dual Inhibitors of HIV Reverse Transcriptase and Integrase
... donor interaction in PLIF, MOE generated a list of conformations with the hydrogen bond between hydrogen of the amine of pyridinone and oxy- gen of carbonyl group of Lys101 (Figure ... See full document
41
Inhibitory effect of aqueous dandelion extract on HIV 1 replication and reverse transcriptase activity
... primary HIV-1 isolates by targeting the V3 loop of ...as HIV-1 entry inhibitors. These compounds likely inhibit HIV-1 replication by blocking the interaction ... See full document
10
Subtype associated differences in HIV 1 reverse transcription affect the viral replication
... from HIV-1 B and C subtypes on the maturation of HIV virions, accumulation of reverse transcription products, integration of viral DNA, frequency of point mutations in provirus and ... See full document
18
An HIV-1 Replication Pathway Utilizing Reverse Transcription Products That Fail To Integrate
... duction. We found that when T cell activation was induced several days after infection, Vpr blocked activation-induced T cell prolif- eration and virus was produced only from the nonproliferating activated cells. Our ... See full document
20
Mutations in HIV-1 Reverse Transcriptase Affect the Errors Made in a Single Cycle of Viral Replication
... frequent during reverse transcription and has been implicated in the generation of indel mutations ...transfer(s) between two RNA templates during minus-strand DNA synthesis can result ... See full document
13
Molecular Modeling of Quinoline Based Compounds as Potential Dual Inhibitors of Reverse Transcriptase and Integrase of HIV
... maintaining interaction with important ami- noacids for this ...were between the substituent in C-4 of each molecule with Tyr188 and the conserved aminoa- cids Trp229; and the interaction of ... See full document
27
Interaction between Hepatitis B Virus Core Protein and Reverse Transcriptase
... core-Pol interaction occurs between Pol and capsid particles or that Pol interacts with a core monomer/dimer which is subsequently incorporated into a newly formed capsid ...Pol interaction with ... See full document
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