[PDF] Top 20 DNA Mismatch Repair Proteins Are Required for Efficient Herpes Simplex Virus 1 Replication
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DNA Mismatch Repair Proteins Are Required for Efficient Herpes Simplex Virus 1 Replication
... either 1% Triton X-100 in PBS (Fix/Perm type 1) or with ice-cold acetone for 2 min at room temperature (Fix/Perm type ...soluble proteins as previously described (12, ... See full document
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Arginine Methylation of the ICP27 RGG Box Regulates ICP27 Export and Is Required for Efficient Herpes Simplex Virus 1 Replication
... dishes and in- fected the next day at a MOI of 10 with the viruses indicated in each figure. Infections were allowed to proceed at 37°C, and the cells were collected 6 h after infection by harvesting the infected cells ... See full document
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Efficient Herpes Simplex Virus 1 Replication Requires Cellular ATR Pathway Proteins
... Herpes simplex virus 1 (HSV-1) is a double-stranded DNA virus that replicates in the nucleus of the host cell and is known to interact with several components of the ... See full document
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Nucleolin Is Required for Efficient Nuclear Egress of Herpes Simplex Virus Type 1 Nucleocapsids
... Herpes simplex virus type 1 (HSV-1) is an enveloped DNA virus and one of the most common human pathogens, causing a wide variety of diseases such as mucocutaneous ... See full document
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The ATM and Rad3-Related (ATR) Protein Kinase Pathway Is Activated by Herpes Simplex Virus 1 and Required for Efficient Viral Replication
... following DNA damage ...HSV-1 replication centers while these structures acquire strong reactivity with an ATR/ATM substrate antibody recognizing phospho-SQ/TQ ...HSV-1 replication is ... See full document
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Herpes Simplex Virus Type 1 DNA-Packaging Protein UL17 Is Required for Efficient Binding of UL25 to Capsids
... separated proteins were screened by Western blotting using UL6, UL17, UL25, and VP23 ...was required for the attachment of UL6 to ...for efficient binding of UL25 to B ...wt virus or the ... See full document
9
Inhibition of Herpes Simplex Virus Type 1 Replication by Adeno-Associated Virus Rep Proteins Depends on Their Combined DNA-Binding and ATPase/Helicase Activities
... and DNA repair. ATM protein kinase activity is activated upon DNA damage stimuli, and this activation has been attributed to intermolec- ular autophosphorylation on serine 1981 and dissociation of ... See full document
17
SAMHD1 Restricts Herpes Simplex Virus 1 in Macrophages by Limiting DNA Replication
... for efficient infection and spread in the host ...encodes proteins involved in nucleotide biosynthesis and DNA metabolism (thymidine kinase, ribonucleotide reductase, de- oxyuridine triphosphatase, ... See full document
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The Enhanced DNA Replication Fidelity of a Mutant Herpes Simplex Virus Type 1 DNA Polymerase Is Mediated by an Improved Nucleotide Selectivity and Reduced Mismatch Extension Ability
... change required for switching of the active ...type 1 Pol crystal structure shows two asymmetry units, one of which has a structural conformation consisting of the pre-N-terminal domain, the N-terminal ... See full document
5
Roles of p53 in Herpes Simplex Virus 1 Replication
... senescence, DNA repair, autophagy, and innate im- mune control (21, ...reduce replication of some viruses, and, therefore, these viruses have ac- quired mechanisms to counteract p53 in infected cells ... See full document
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Pocket Protein p130/Rb2 Is Required for Efficient Herpes Simplex Virus Type 1 Gene Expression and Viral Replication
... pocket proteins and E2F is complex and each pocket protein may play a unique and nec- essary role in cell cycle ...a virus that acts to halt cell proliferation would benefit from its ...HSV-1 ... See full document
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Asna1/TRC40 that mediates membrane insertion of tail anchored proteins is required for efficient release of Herpes simplex virus 1 virions
... tail-anchored proteins specifically bound to Asna1/TRC40 but independently localized to their target ...is required for efficient HSV1 ...the replication cycle like virion entry and overall ... See full document
9
The Torsin Activator LULL1 Is Required for Efficient Growth of Herpes Simplex Virus 1
... the replication or the mainte- nance/stability of the HSV-1 genome is affected by deletion of ...and virus production are decreased by approximately 10-fold in LULL1 KO cells compared to control ... See full document
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Functional order of assembly of herpes simplex virus DNA replication proteins into prereplicative site structures.
... wt virus and treated with PAA ...not required for ICP8 localization (3, ...(Table 1). Although the per- centage of UL42 mutant virus-infected cells showing a punc- tate distribution for ICP8 ... See full document
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Proteolytic Cleavage of VP1-2 Is Required for Release of Herpes Simplex Virus 1 DNA into the Nucleus
... viral proteins by cellular or viral proteases plays an important role in various stages of the viral life ...viral proteins has been well documented as playing an impor- tant role in the assembly of newly ... See full document
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ICP0 Is Required for Efficient Reactivation of Herpes Simplex Virus Type 1 from Neuronal Latency
... infectious virus in cells or tissues that contain viral genomes, whereas reactivation has been defined as the de novo production of new infectious virus from cells containing latent viral genomes (13, ... See full document
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Herpes simplex virus type 1 alkaline nuclease is required for efficient processing of viral DNA replication intermediates.
... rolling-circle replication (model i, above), since this model makes no provision for ...free DNA end capa- ble of strand invasion, Zhang et ...HSV replication functions are sufficient for ... See full document
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Nucleolin Is Required for an Efficient Herpes Simplex Virus Type 1 Infection
... viral replication, and cellular stress re- sponses (3, ...viral DNA replication, virus assembly, and control of intracellular trafficking (for reviews see references 22 and ...nonribosomal ... See full document
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The Pre-NH2-Terminal Domain of the Herpes Simplex Virus 1 DNA Polymerase Catalytic Subunit Is Required for Efficient Viral Replication
... the replication fork or other- wise positively impacts viral DNA ...the replication fork ...HSV DNA polymerase holoenzyme, ICP8, and viral alkaline nuclease UL12 have been captured from ... See full document
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Evidence that the herpes simplex virus type 1 uracil DNA glycosylase is required for efficient viral replication and latency in the murine nervous system.
... Assessment of the latent viral DNA burden by quantitative PCR QPCR demonstrated a reduction in the number of copies of the Ung- mutant viral Downloaded from http://jvi.asm.org/ on Novemb[r] ... See full document
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