[PDF] Top 20 One naive T cell, multiple fates in CD8+ T cell differentiation
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One naive T cell, multiple fates in CD8+ T cell differentiation
... all naive T cell clones of which the progeny persisted into resting memory phase also had descen- dants that were able to respond to secondary infection, naive barcode-labeled OT-I T ... See full document
12
Aging promotes acquisition of naive like CD8+ memory T cell traits and enhanced functionalities
... major T cell subsets in multiple tissues across 6 decades of life by Thome et ...of T cell memory as an extended dedifferentia- tion process in the wake of a defined stimulatory event, ... See full document
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mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation
... Mann-Whitney t tests; comparisons among 3 or more independent groups were calculated by a Kruskal-Wallis ANOVA with a Dunn’s ...of multiple comparison survival curves was determined after performing ... See full document
20
IL 12 is required for differentiation of pathogenic CD8+ T cell effectors that cause myocarditis
... of T-cell myocarditis that has allowed us to compare the in vivo behavior of different populations of T cells specific for the same defined myocardial ...smooth-muscle cell–specific promoter ... See full document
11
Molecular profiling of cytomegalovirus induced human CD8+ T cell differentiation
... tive size of the circle represents the size of the respective group. (C) Average gene expression pat- terns (± 1 SD) of the 4 clusters found using the CLICK algorithm. The gene set included all genes greater than 10-fold ... See full document
15
Allogeneic Differences in the Dependence on CD4+ T-Cell Help for Virus-Specific CD8+ T-Cell Differentiation
... The differentiation of antiviral CD8 ⫹ effector T cells during acute infection is believed not to require CD4 ⫹ T-cell help, with helper T cells instead being critical for ... See full document
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Differentiation associated regulation of microRNA expression in vivo in human CD8+ T cell subsets
... with CD8 + T cell differentiation status, the rela- tive expression levels of the microRNAs from groups A, B and C were calculated for each CD8 + lymphocyte sub- set relative to those ... See full document
8
A comprehensive characterization of aggravated aging-related changes in T lymphocytes and monocytes in end-stage renal disease: the iESRD study
... immune cell homeostasis, duration of ESRD or dialysis treatment (dialysis vintage years) should have a significant impact on the severity of observed aging phenotype, independent from the effect of ...immune ... See full document
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Memory T cell–driven differentiation of naive cells impairs adoptive immunotherapy
... In multiple preclinical models, minimally differentiated T N , T SCM , and T CM cell subsets exhibit superior persistence (12, 18, 27, 59–62) and enhanced antitumor (18, 27, 59), ... See full document
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Multiple sclerosis
... to naive T cells in the context of co-stimulatory ...drive differentiation of these naive autoreactive T cells to a Th1 or Th17 cell phenotype; howev- er, these potentially ... See full document
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CD8<sup>+</sup> memory T-cell inflation renders compromised CD4<sup>+</sup> T-cell-dependent CD8<sup>+</sup> T-cell immunity via naïve T-cell anergy
... after T-cell transfer (Figure 1C) were either boosted with DC Ova for assessment of recall responses or challenged with Ova-expressing BL6-10 Ova tumor cells for assessment of protective ...these CD8 ... See full document
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Antigen processing and T cell priming by mouse dendritic cells
... two cell types were found to be generally similar functionally, both being able to efficiently induce allogeneic responses, a major distinguishing trait of these ...dendritic cell and ... See full document
216
Human CD8+ and CD4+ T Cell Memory to Lymphocytic Choriomeningitis Virus Infection
... Tetramer-specific T cell popu- lations were positively enriched by incubating cells with 50 l of anti-APC or 50 l of anti-PE microbeads (Miltenyi Biotech) for 20 min at ...tetramer-specific CD8 ⫹ ... See full document
11
Functional analysis of the CD8[beta] polypeptide and its role in T cell differentiation
... for stable cell surface expression. Assembly occurs within the rough endoplasmic reticulum (rER) of the cell, where the MHC class I heavy chains and p2-m form dimers. Endogenous peptides presented by the ... See full document
248
Cytomegalovirus Infection in Gambian Infants Leads to Profound CD8 T-Cell Differentiation
... Production of IFN- ␥ by peptide-specific cells is impaired in younger infants. The IFN- ␥ production of the PBMCs of sam- ples that responded to tetramers was assessed by ELISpot assay, using the peptide incorporated ... See full document
11
Multiple specificities in the murine CD4+ and CD8+ T-cell response to dengue virus.
... 1 T-cell clones have shown the Th1 phenotype, producing gamma interferon and IL-2 and lysing dengue virus- infected MHC class II-expressing cells (14a, ...that one of five murine dengue ... See full document
7
Signatures of CD8+ T cell dysfunction in AML patients and their reversibility with response to chemotherapy
... untransformed T cell values were summarized using descriptive statistics and data presented on the raw ...the T cell flow cytometry measurements, and comparisons between HCs and AML patients ... See full document
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Memory T cells skew toward terminal differentiation in the CD8+ T cell population in patients with acute myeloid leukemia
... memory T cell subsets between the AMLy, AML-CR, and HIy ...memory T cell dis- tribution was demonstrated for AML patients who achieved CR after chemotherapy ...and CD8+ T SCM ... See full document
5
The Role of Ikaros in CD8+ T cell Biology
... naïve CD8+ T cells activated in the presence of IL-2 can mediate both tumor rejection and ...activated CD8+ T cells (Fig 7), this has implications for immunopathology as Granzyme B+ ... See full document
102
Fate of a Naive T Cell: A Stochastic Journey
... a T cell consists of short intervals in the blood (less than a minute each) between longer sojourns in lung, liver, spleen and lymph ...a T cell (migration, division or death) is stochastic, ... See full document
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