[PDF] Top 20 Neuronal Subtype Determines Herpes Simplex Virus 1 Latency-Associated-Transcript Promoter Activity during Latency
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Neuronal Subtype Determines Herpes Simplex Virus 1 Latency-Associated-Transcript Promoter Activity during Latency
... LAT promoter activity, since these are mostly associated with hair or encapsulated mechanoreceptor structures in the dermis ...this subtype does get infected, most likely through round-trip ... See full document
15
Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene Promotes Neuronal Survival
... LAT promoter and 827 bp of the 5 ⴕ end of the primary LAT mRNA was introduced into strain 17syn ⴙ ...which latency was ...of latency in the ... See full document
16
In vivo deletion analysis of the herpes simplex virus type 1 latency-associated transcript promoter.
... 1994 During herpes simplex virus latency, transcripts accumulate from a single transcription unit of the viral ...The promoter for these latency-associated ... See full document
7
The herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latency.
... Medicine, 1 and Division of Infectious Diseases, Children’s Hospital Medical Center, 2 Cincinnati, Ohio Received 4 February 1997/Accepted 17 April 1997 Herpes simplex virus type 1 ... See full document
9
Interactions between Herpesvirus Entry Mediator (TNFRSF14) and Latency-Associated Transcript during Herpes Simplex Virus 1 Latency
... proteins herpes simplex virus (HSV) uses for attachment/en- ...Interestingly, latency-associated transcript (LAT), the only viral gene consistently expressed during ... See full document
11
In Vivo Knockdown of the Herpes Simplex Virus 1 Latency-Associated Transcript Reduces Reactivation from Latency
... LAT promoter and portions of the 5= exon coding region have an increase in apoptotic neurons during the acute infection (9, 20, 35), resulting in a 2- to 3-fold decrease in total HSV-1 DNA detected ... See full document
10
The Latency-Associated Transcript Gene Enhances Establishment of Herpes Simplex Virus Type 1 Latency in Rabbits
... The latency-associated transcript (LAT) gene the only herpes simplex virus type 1 (HSV-1) gene abundantly transcribed during neuronal latency, ... See full document
7
Regulation and cell-type-specific activity of a promoter located upstream of the latency-associated transcript of herpes simplex virus type 1.
... To examine whether the in vivo neuron-specific expression of LAT may be reflected in selective activity of the upstream promoter in cell culture, we compared the activities of pBB-8 and [r] ... See full document
11
Evidence for a Bidirectional Element Located Downstream from the Herpes Simplex Virus Type 1 Latency-Associated Promoter That Increases Its Activity during Latency
... the activity of the LTE in latently infected ...the activity of the LAP within latently infected neu- rons, the combined activity of the LAP-LTE substantially de- creases between 4 and 28 days ...of ... See full document
10
The Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Enhancer/rcr Is Hyperacetylated during Latency Independently of LAT Transcription
... domain associated with modified histones typical of euchromatin, while the lytic gene regions would be contained within transcriptionally nonpermissive do- mains, similar to cellular ...LAT promoter was ... See full document
11
Activity of herpes simplex virus type 1 latency-associated transcript (LAT) promoter in neuron-derived cells: evidence for neuron specificity and for a large LAT transcript.
... that in ganglia from latently infected rabbits, we occasionally detected what appeared to be very faint in situ hybridization with probes upstream of the 2-kb LAT (30). Since then other [r] ... See full document
10
The latency-associated promoter of herpes simplex virus type 1 requires a region downstream of the transcription start site for long-term expression during latency.
... (Fig. 1), we would expect to see a band at around 350 bases for LAT RNA coming from the LAT locus in the repeat ...fused transcript, or it could have been an internal initiation or even a trapped ... See full document
6
Two herpes simplex virus type 1 latency-active promoters differ in their contributions to latency-associated transcript expression during lytic and latent infections.
... particular neuronal cell type or LAT production may be dy- namic and changing within all latently infected cells, perhaps depending on available transcription factors and/or changes in splicing or other ... See full document
10
Localization of cis-acting sequence requirements in the promoter of the latency-associated transcript of herpes simplex virus type 1 required for cell-type-specific activity.
... We have previously demonstrated (A. 64:3269-3279, 1990) the selective activity in human neuroblastoma cells (IMR-32) of a promoter located upstream of the latency- associated transcript [r] ... See full document
10
Herpes Simplex Virus Latency-Associated Transcript Sequence Downstream of the Promoter Influences Type-Specific Reactivation and Viral Neurotropism
... HSV-1. During acute disease, a greater percentage of animals infected with HSV2-LAT-S1 than with HSV-2 developed urinary tract dysfunction, sugges- tive of more pronounced autonomic nervous system involve- ... See full document
9
The activity of the pseudorabies virus latency-associated transcript promoter is dependent on its genomic location in herpes simplex virus recombinants as well as on the type of cell infected.
... Regulation and cell-type- specific activity of a promoter located upstream of the latency- associated transcript of herpes simplex virus type 1. Molecular analysis of herpes simplex viru[r] ... See full document
5
Herpes simplex virus type 1 latency-associated transcript (LAT) promoter deletion mutants can express a 2-kilobase transcript mapping to the LAT region.
... Expression of herpes simplex virus type 1 latency-associated transcripts in the trigeminal ganglia of mice during acute infection and reactivation of latent infection. Identification of [r] ... See full document
8
Regions of the Herpes Simplex Virus Type 1 Latency-Associated Transcript That Protect Cells from Apoptosis In Vitro and Protect Neuronal Cells In Vivo
... the latency-associated transcript (LAT) region of herpes simplex virus type 1 (HSV-1) is effective at blocking virus-induced apoptosis both in vitro and in ... See full document
13
A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation.
... of latency, future investigations based on the XIST model should involve structural studies of the ...ICP4 promoter (51), and if the ICP4 promoter were methylated during latency, one ... See full document
11
A Herpes Simplex Virus Type 1 Latency-Associated Transcript Mutant with Increased Virulence and Reduced Spontaneous Reactivation
... Why does the deletion of LAT nucleotides 76 to 447 in LAT2.9A increase virulence when the deletion of LAT nucle- otides 2161 to 11667 (dLAT2903) does not? Asked another way, why does the insertion of LAT nucleotides ... See full document
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