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[PDF] Top 20 Nucleotide sequence of the herpes simplex virus type 2 thymidine kinase gene.

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Nucleotide sequence of the herpes simplex virus type 2 thymidine kinase gene.

Nucleotide sequence of the herpes simplex virus type 2 thymidine kinase gene.

... GALLOWAY* Fred Hutchinson Cancer Research Center, Seattle, Washington 98104 We have determined the complete nucleotide sequence of the thymidine kinase gene of herpes simplex virus HSV t[r] ... See full document

6

Splicing-Independent Expression of the Herpes Simplex Virus Type 1 Thymidine Kinase Gene Is Mediated by Three cis-Acting RNA Subelements

Splicing-Independent Expression of the Herpes Simplex Virus Type 1 Thymidine Kinase Gene Is Mediated by Three cis-Acting RNA Subelements

... TK function is not CRM1 dependent. The hnRNP L-PPE interaction was postulated to possibly function analogously to Rev export of RRE-containing RNA (18). Rev export depends on the presence of a leucine-rich nuclear export ... See full document

8

The Genome Sequence of Herpes Simplex Virus Type 2

The Genome Sequence of Herpes Simplex Virus Type 2

... of gene content. In addition, we searched the HSV-2 genome sequence for possible additional protein-coding regions by us- ing criteria of codon usage plus similarity and divergence be- tween HSV-1 ... See full document

12

Physical mapping and nucleotide sequence of a herpes simplex virus type 1 gene required for capsid assembly.

Physical mapping and nucleotide sequence of a herpes simplex virus type 1 gene required for capsid assembly.

... 2169 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest In this report, we describe some phenotypic properties of a temperature-sensitive mutant of herpes simplex type 1 H[r] ... See full document

11

Identification and mapping of two polypeptides encoded within the herpes simplex virus type 1 thymidine kinase gene sequences.

Identification and mapping of two polypeptides encoded within the herpes simplex virus type 1 thymidine kinase gene sequences.

... McGEOCH Medical Research Council Virology Unit, Glasgow, Gll 5JR Scotland mRNA's homologous to the herpes simplex virus type 1 DNA restriction endonuclease fragment BamHI p, which contai[r] ... See full document

13

Positive control of the herpes simplex virus thymidine kinase gene requires upstream DNA sequences.

Positive control of the herpes simplex virus thymidine kinase gene requires upstream DNA sequences.

... HALPERN Pathology Department, McMaster University, Hamilton, Ontario, Canada L8N 3Z5 We examined the ability of deleted versions of the herpes simplex virus type 1 thymidine kinase gene,[r] ... See full document

10

Reactivation of thymidine kinase-defective herpes simplex virus is enhanced by nucleoside.

Reactivation of thymidine kinase-defective herpes simplex virus is enhanced by nucleoside.

... Others also reported reactivation of HSV which was re- stricted to drg, in those instances involving TK 1 HSV (35, 38). It might be of interest to measure TK levels in sensory ganglia, although it would be most useful ... See full document

6

Properties of Cells Carrying the Herpes Simplex Virus Type 2 Thymidine Kinase Gene: Mechanisms of Reversion to a Thymidine Kinase-Negative Phenotype

Properties of Cells Carrying the Herpes Simplex Virus Type 2 Thymidine Kinase Gene: Mechanisms of Reversion to a Thymidine Kinase-Negative Phenotype

... However we cannot exclude the possibility that Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest cleic acid hybridizations studies have shown that class 3 revertants reta[r] ... See full document

10

Diverse Herpes Simplex Virus Type 1 Thymidine Kinase Mutants in Individual Human Neurons and Ganglia

Diverse Herpes Simplex Virus Type 1 Thymidine Kinase Mutants in Individual Human Neurons and Ganglia

... An extremely high level of HSV-1 DNA was detected in ganglia from an immunocompromised patient. An 18-year-old woman (patient 708) presented at the Clinical Center, Na- tional Institutes of Health, Bethesda, MD, with an ... See full document

10

The nucleotide sequence, 5' end, promoter domain, and kinetics of expression of the gene encoding the herpes simplex virus type 2 latency-associated transcript.

The nucleotide sequence, 5' end, promoter domain, and kinetics of expression of the gene encoding the herpes simplex virus type 2 latency-associated transcript.

... The 5619 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The sequence of the herpes simplex virus type 2 HSV-2 latency-associated transcript LAT region resembles that o[r] ... See full document

5

Ultrasound-targeted microbubble destruction mediated herpes simplex virus-thymidine kinase gene treats hepatoma in mice

Ultrasound-targeted microbubble destruction mediated herpes simplex virus-thymidine kinase gene treats hepatoma in mice

... Proteins were extracted using protein extraction reagent,48 hours after transfection and save at -20°C;, following a protocol provided by the manufacture. TK protein expression was detected with western-blot. 40 ml/L ... See full document

6

Identification of the herpes simplex virus DNA sequences present in six herpes simplex virus thymidine kinase-transformed mouse cell lines.

Identification of the herpes simplex virus DNA sequences present in six herpes simplex virus thymidine kinase-transformed mouse cell lines.

... The studies described in this paper were designed to both unambiguously map the HSV-1 and HSV-2 tk genes and to study the patterns of incorporation of non-tk gene viral DNA sequences in [r] ... See full document

14

Development of a helper-independent human adenovirus vector and its use in the transfer of the herpes simplex virus thymidine kinase gene.

Development of a helper-independent human adenovirus vector and its use in the transfer of the herpes simplex virus thymidine kinase gene.

... To test the usefulness of this vector, the herpes simplex virus type 1 HSV-1 thymidine kinase gene tk along with its regulatory sequences was inserted into the unique XbaI site of dlEl,3[r] ... See full document

8

Association between sensitivity of viral thymidine kinase associated acyclovir resistant herpes simplex virus type 1 and virulence

Association between sensitivity of viral thymidine kinase associated acyclovir resistant herpes simplex virus type 1 and virulence

... of virus inoculation, virus titers in tears of mice inoculated with each of HSV-1 clones through corneal inoculation were mea- sured ...The virus load kinetics in tears of HSV-1 CL18 and CL19 were ... See full document

7

A conserved open reading frame that overlaps the herpes simplex virus thymidine kinase gene is important for viral growth in cell culture.

A conserved open reading frame that overlaps the herpes simplex virus thymidine kinase gene is important for viral growth in cell culture.

... Nucleotide sequence of the herpes simplex virus type 2 HSV-2 thymidine kinase gene and predicted amino acid sequence of thymidine kinase polypeptide and its comparison with the HSV-1 thy[r] ... See full document

5

Construction and isolation of a transmissible retrovirus containing the src gene of Harvey murine sarcoma virus and the thymidine kinase gene of herpes simplex virus type 1.

Construction and isolation of a transmissible retrovirus containing the src gene of Harvey murine sarcoma virus and the thymidine kinase gene of herpes simplex virus type 1.

... SCOLNICK'* Laboratory of Tumor Virus Genetics, National Cancer Institute, Bethesda, Maryland 20205,' and Department of Microbiology, University of Chicago, Chicago, Illinois 606372 We co[r] ... See full document

10

Structure and expression of the herpes simplex virus type 2 glycoprotein gB gene.

Structure and expression of the herpes simplex virus type 2 glycoprotein gB gene.

... Anatomy of the herpes simplex virus type 1 strain F glycoprotein B gene: primary sequence and predicted protein structure of the wild type and of monoclonal antibody-resistant mutants.. [r] ... See full document

10

Mutation Spectra of Herpes Simplex Virus Type 1 Thymidine Kinase Mutants

Mutation Spectra of Herpes Simplex Virus Type 1 Thymidine Kinase Mutants

... 3-G sequence (amino acid 72); and one Y7 mutant contained a deletion of a C:G base pair within the 3-C region (amino acid ...the sequence of repetitive nucleotides, the higher the frequency of frameshift ... See full document

7

Thymidine kinase-deficient herpes simplex virus type 2 genital infection in guinea pigs.

Thymidine kinase-deficient herpes simplex virus type 2 genital infection in guinea pigs.

... Our observation that latent virus may also be recovered from external genital skin and uterine cervix after recovery from HSV-2 genital infection suggests that extraneural latent virus m[r] ... See full document

7

Discrimination of Herpes Simplex Virus Type 2 Strains by Nucleotide Sequence Variations

Discrimination of Herpes Simplex Virus Type 2 Strains by Nucleotide Sequence Variations

... FIG. 2. Phylogenetic analyses of 400-bp regions in the UL53 (A), US1 (B), and US4 (C) genes and in NC3 (D). Sequence data from all 36 HSV-2 clinical strains (shown as strains 1 to 36) and strain HG52 ... See full document

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