[PDF] Top 20 Original Article JARID1B modulates breast cancer cell apoptosis by regulating p53 expression
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Original Article JARID1B modulates breast cancer cell apoptosis by regulating p53 expression
... 5-μm thick specimen sections were embedded in paraffin. The sections were deparaffinized in xylene, rehydrated with graded alcohol, and endogenous peroxide activity was blocked with 3% H 2 O 2 for 15 min. Tissue sections ... See full document
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Original Article Expression of aryl hydrocarbon receptor in relation to p53 status and clinicopathological parameters in breast cancer
... The p53 protein, a prototypical tumor suppressor, plays a central role in the growth and differentiation of normal breast epithelium ...form, p53 can be involved in the induction of apoptosis ... See full document
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Original Article microRNA-497 induces cell apoptosis by negatively regulating Bcl-2 protein expression at the posttranscriptional level in human breast cancer
... Eppendorf Biotech, Germany). Supernatants were collected and the protein concentrations were quantified using a BCA protein assay kit (Beyotime). Protein samples were denatured with 5× SDS loading buffer (Beyotime) at ... See full document
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Original Article MiR-148a suppresses invasion and induces apoptosis of breast cancer cells by regulating USP4 and BIM expression
... tumor cell motility via activating the targets like Wnt10B in cancer-associated fibroblasts ...gastric cancer [16, ...regulates cell survival by tar- geting CDC25B [18], and promotes ... See full document
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Original Article Role of TM4SF1 in regulating breast cancer cell migration and apoptosis through PI3K/AKT/mTOR pathway
... on breast cancer cell line MDA-MB-231 invasion and apoptosis and its mechanism through PI3K/AKT/ mTOR ...mRNA expression of TM4SF1 in each ...TM4SF1 expression on MDA- MB-231 ... See full document
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Original Article Interleukin 7 signaling prevents apoptosis by regulating bcl-2 and bax via the p53 pathway in human non-small cell lung cancer cells
... the expression level of IL-7R was higher in A549 and H1299 lung can- cer cell lines than in the HBE cell line, consis- tent with results observed in NSCLC ...the apoptosis of A549 cells, and ... See full document
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Original Article JARID1B deletion induced apoptosis in Jeko-1 and HL-60 cell lines
... of JARID1B was evidenced and it was shown to act as a tran- scriptional repressor in breast cancer, promot- ing tumor progression by repression of tumor suppressor genes, including BRCA1 ...[5]. ... See full document
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Original Article Long non-coding RNA MALAT1 promote triple-negative breast cancer progression by regulating miR-204 expression
... the expression of these microRNAs in response to MALAT1 ...the expression of miR-204 in 38 pairs of human TNBC tissues and adjacent normal breast tis- sues used ...204 expression was ... See full document
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Original Article USP43 promotes tumorigenesis through regulating cell cycle and EMT in breast cancer
... in breast carcinoma. We first detected the expression level of those proteins in breast cancer tissue ...high expression, but USP41 and USP50 had similar expression level in ... See full document
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Original Article MLF1IP promotes cells proliferation and apoptosis by regulating CyclinD1 in breast cancer
... gene expression in The Cancer Genome Atlas (TC- GA) cohort containing 1091 breast cancer samples and 113 normal breast tissue samples ...in breast cancer tissues compared ... See full document
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Anticancer Effects of a New SIRT Inhibitor, MHY2256, against Human Breast Cancer MCF-7 Cells via Regulation of MDM2-p53 Binding
... activated p53 is induction of cell cycle arrest, apoptosis, and DNA repair [42, ...the cell cycle by SIRT is essential in the cytotoxicity to cancer ...of p53 activity on ... See full document
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... Squamous cell carcinoma (ESCC) cases in the north of Iran, especially the Guilan province, is a region with high ...squamous cell carcinoma of other regions of the body like cervix and oral ...control. ... See full document
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Original Article Prognostic significance of cancer stem cell marker CD133 expression in breast cancer
... The cancer stem cell antigens CD133, BCRP1/ABCG2 and CD117/c-KIT are not associated with progno- sis in resected early-stage non-small cell lung ...and expression pro- files of stem ... See full document
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Original Article A novel long noncoding RNA IRAIN regulates cell proliferation in non small cell lung cancer
... IRAIN expression was sig- nificantly increased in tumor samples as shown in Figure 1A ...its expression and clinicopatho- logical parameters ...IRAIN expression level in NSCLC was significantly ... See full document
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Original Article MicroRNA-204 targets JAK2 in breast cancer and induces cell apoptosis through the STAT3/BCl-2/survivin pathway
... 3C) expression of JAK2, which was abolished by co- transfection of miR-204 ...JAK2 expression is directly targeted and regulated by miR-204 and suggested that miR-204 downregulation might result in ... See full document
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Original Article SUMO-1 expression modulates non-small cell lung cancer progression
... SUMO1 expression (n = 42) was ...(Squamous cell carcinoma) patients with SU- MO1 overexpression (n = 60) was 12 months (95% CI = 5-19 months), while the median sur- vival time of those with SUMO1 ... See full document
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Original Article MEG3 regulates cell cycle progression via control of P53 expression in gastric cancer
... relative expression of RNA in our experiments. The PCR primers for MEG3, P53 mRNA and GAPDH were as follows: MEG3 sense 5’GCCTGCTGCCCATC- TACAC3’ and reverse 5’CCTCTTCATCCTTTGC- CATC3’; P53 sense ... See full document
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<p>Long Noncoding RNA LINC00460 Modulates MMP-9 to Promote Cell Proliferation, Invasion and Apoptosis by Targeting miR-539 in Papillary Thyroid Cancer</p>
... and cell lines (K1 and TPC-1) in comparison with adjacent normal tissues and human normal thyroid cell line Nthy-ori 3 – 1, suggesting LINC00460 was considered as a potential oncogenic in ...non-small ... See full document
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Original Article miR-29c expression predicts poor prognosis in patients with gastric cancer and its role in ROCK-I expression and cell apoptosis
... and apoptosis is induced. In a report [19] the expression of miR-29c was low in head and neck squamous cell carcinoma tissues, and it was related to the relapse-free survival time of ...liver ... See full document
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Original Article Celastrol inhibits colon cancer cell proliferation by downregulating miR-21 and PI3K/AKT/GSK-3β pathway
... the apoptosis. We found Celastrol inhibited colon cancer cell viability in a dose-dependent manner companied with PCNA ...downregulation. Apoptosis was induced by ...BCL-2 expression ... See full document
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