[PDF] Top 20 Patterns of Changes in Human Immunodeficiency Virus Type 1 V3 Sequence Populations Late in Infection

... The V3-HTA patterns from the first and last time points were evaluated initially to determine the amounts of change in V3 sequence populations, which were primarily changes in ... See full document

... peak infection, including GRP 78 (BIP), ERp44, GRP 94 (endoplasmin), ERp 29 and mt ...stomatitis virus glycoprotein (45), but interactions with HIV proteins have not been found so ...for virus ... See full document

... Figure 1 shows sequence comparisons for two participants, illustrating three features of env gene evolution that were observed among all participants (for complete data sets, see reference ...the ... See full document

... evolutionary patterns of the major V3 and p17 sequences of patients A, C, D, and ...HIV-1 infection. A subtype B sequence (G006 from patient G) or a subtype E (V3)/A (p17) ... See full document

... two patterns: nucleotide differences clustered within either V1 or V2, or differences widely distributed across both V1 and V2 (mutation ratio ⬍ 2:1 between V1 and V2) (data not ...clustered sequence ... See full document

... the V3 region. Such stability suggests that HIV-1 subtypes are opti- mally adapted to the present ...(simian immunodeficiency virus) into the human population, the adaptation of this ... See full document

... by sequence- selective PCR was quite reproducible and close to expected values (Table ...by sequence-selective PCR and those based on the evaluation of clonal ... See full document

... of V3 sequence variability among subtype C human immunodeficiency virus type 1 (HIV-1) sequences from plasma-derived viral RNA present in infected men from ... See full document

... identified V3-dependent determinants have V3 loop sequences which are extremely similar to one another and to the North American V3 consensus sequence (26), and they have a relatively ... See full document

... 5714 Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest Synthetic polymeric constructions SPCs including the consensus sequence of the human immunodeficiency virus type 1 H[r] ... See full document

... CD8 1 cells was restricted to the thymus. At 6 months after infection, we were unable to detect infected CD8 1 cells in the spleen, suggesting that infected CD8 1 thymocytes did not emigrate ... See full document

... GPGRAF sequence. It is also evident that neither conserved sequence, the amino- terminal base CTRPNNNTRK nor the carboxy-terminal base GDIRQAHC of the V3 loops is recognized by serum anti- ...the ... See full document

... in V3 cannot be explained by phylogenetic relationships among se- ...V1V3-set 1 and V3C4-set 1, neighbor- joining trees were constructed from nucleotide sequence align- ...same V3 ... See full document

... the V3 loop primarily controls coreceptor specificity, other envelope regions such as V1/2 can be important with certain viruses for specific coreceptor utili- zation (44, 68, ...to V3 of five of the ... See full document

... of human immunodeficiency virus type 1 (HIV-1) usually results in outgrowth of viruses with macrophage-tropic phenotype and consensus non-syncytium-inducing (NSI) V3 loop ... See full document

... In early infection, HIV variants with an NSI/macrophage- There are several interpretations of the high degree of observed sequence diversity between published sequences of the envelope g[r] ... See full document

... templates. V3-HTA was performed with the subtype C probe as described previously ...159-bp V3 sequence as that used for the subtype C probe from a JR-FL molecular subclone (pUC112-1 from Irvin ... See full document

... Human immunodeficiency virus type 2 (HIV-2) is the sec- ond retrovirus causing immunodeficiency in ...This virus has been de- tected in Europe (14, 15; ...genomic sequence ... See full document

... Western blot immunoblot analysis of the brain proteins was performed with several monoclonal and polyclonal anti-HIV-1 antibodies including polyclonal rabbit anti-HIV-1 gp120 American Bi[r] ... See full document

... Given that the Nef- and Rev-specific transcripts were the most abundant transcripts at most time points posttransfection and given the prior observation that rev and nef gene transcripts[r] ... See full document