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[PDF] Top 20 Power comparison of different methods to detect genetic effects and gene environment interactions

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Power comparison of different methods to detect genetic effects and gene environment interactions

Power comparison of different methods to detect genetic effects and gene environment interactions

... the power of the different ...no power to detect linkage even when accounting for G × E ...the power to detect the gene effect is 78% and is increased to 87% when ... See full document

6

A comparison of methods used to unveil the genetic and metabolic pool in the built environment

A comparison of methods used to unveil the genetic and metabolic pool in the built environment

... the genetic pool, whereas host- associated genera drove the differentiation of the viable population ...as genetic seed banks that may be indispensable for maintaining microbial diversity and thus community ... See full document

16

Modelling local gene networks increases power to detect trans acting genetic effects on gene expression

Modelling local gene networks increases power to detect trans acting genetic effects on gene expression

... in different analyses, the method is not free of ...trans effects [21], there are other ways in which genetic variants can affect expression levels of downstream genes, such as epigenetic ... See full document

13

Retrospective haplotype clustering methods for detecting haplotypes effects and haplotype-environment interactions

Retrospective haplotype clustering methods for detecting haplotypes effects and haplotype-environment interactions

... retrospective methods are sensitive to this assumption of haplotype-environment ...by genetic factors, other methods should be ...these methods can incorporate haplotype clustering, ... See full document

44

Rule based classifier for the analysis of gene-gene and gene-environment interactions in genetic association studies

Rule based classifier for the analysis of gene-gene and gene-environment interactions in genetic association studies

... complex interactions [7]. MDR has a good sensitivity to detect gene-gene and gene- environment interactions; however, the algorithm faces two ...of genetic ... See full document

14

Comparison of 2 models for gene–environment interactions: an example of simulated gene–medication interactions on systolic blood pressure in family based data

Comparison of 2 models for gene–environment interactions: an example of simulated gene–medication interactions on systolic blood pressure in family based data

... complementary geneenvironment interaction methods have been published and incorporated into publicly available software packages to examine interaction effects, including whether ... See full document

7

A systematic comparison of statistical methods to detect interactions in exposome-health associations

A systematic comparison of statistical methods to detect interactions in exposome-health associations

... Statistical interactions are scale dependent, so our results depend on the assumed underlying ...of interactions should refer to the methods described in VanderWeele [24], although most of them are ... See full document

13

Power of grammatical evolution neural networks to detect gene gene interactions in the presence of error

Power of grammatical evolution neural networks to detect gene gene interactions in the presence of error

... the power of each method to detect only correct loci was ...of power, any combination of the four total functional loci simulated as the best model is considered ...a different definition than ... See full document

8

Gene × gene and gene × environment interactions for complex disorders

Gene × gene and gene × environment interactions for complex disorders

... qualitative genetic and environmental fac- tors contributing to quantitative or binary phenotypes, even if the effects are largely due to an interaction display- ing little or no signal detectable by ... See full document

6

Comparison of the power of haplotype based versus single  and multilocus association methods for gene × environment (gene × sex) interactions and application to gene × smoking and gene × sex interactions in rheumatoid arthritis

Comparison of the power of haplotype based versus single and multilocus association methods for gene × environment (gene × sex) interactions and application to gene × smoking and gene × sex interactions in rheumatoid arthritis

... adequate power for the detection of genetic main effects without considering gene × sex interaction in mod- erate sample ...better power than simple LR modeling to detect ... See full document

7

Neural networks for genetic epidemiology: past, present, and future

Neural networks for genetic epidemiology: past, present, and future

... in genetic association studies ...can detect and model the interaction effects in addition to main effects, the selection of variables to evaluate is a major computational ...statistical ... See full document

15

Gene Environment Interactions in Asthma: Genetic and Epigenetic Effects

Gene Environment Interactions in Asthma: Genetic and Epigenetic Effects

... comprised 332 CpG sites in 296 genes that were hypometh- ylated, and 158 sites in 141 genes that were hypermethyl- ated (Fig. 5). CpG site methylations of nasal polyps did not correlate with those of buffy coats, ... See full document

10

Testing gene environment interactions in gene based association studies

Testing gene environment interactions in gene based association studies

... human genetic association studies faces many challenges that are well known in the field, such as issues of computational burden, model dependency, and multiple testing ...of gene-environment ... See full document

6

Genetic polymorphisms in PTPN22, PADI 4, and CTLA 4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene environment interactions with heavy cigarette smoking

Genetic polymorphisms in PTPN22, PADI 4, and CTLA 4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene environment interactions with heavy cigarette smoking

... sufficient power to detect a small elevation in risk (with OR in the order of ...hoc power calculation, for this CTLA-4 genotype with a risk allele frequency of ...71% power to detect ... See full document

12

A quantitative comparison of different methods to detect cardiorespiratory coordination during night-time sleep

A quantitative comparison of different methods to detect cardiorespiratory coordination during night-time sleep

... six methods was obtained as ...two different methods for each data ...this comparison, only those pairs of per- centages are used in which at least one percentage is greater than ... See full document

13

Effect of gene environment interactions on lung function and cardiovascular disease in COPD

Effect of gene environment interactions on lung function and cardiovascular disease in COPD

... extremes of the distribution for rate of decline or baseline lung function. When we analyzed the entire LHS cohort, only the IL6 rs2069825 SNP remained significant. This could indicate that the IFNG rs2069727, IL1RN ... See full document

11

Different Methods of Power Quality Improvement using DSTATCOM With T Connected Transformer and Their Possibility According to Load

Different Methods of Power Quality Improvement using DSTATCOM With T Connected Transformer and Their Possibility According to Load

... a power VSC specifically supported on elevated power electronics technology as ...reactive power switch over among the D- STATCOM and the ac ...reactive power to make available voltage ... See full document

5

Epigenetics and obesity: the devil is in the details

Epigenetics and obesity: the devil is in the details

... Interestingly, recent genome-wide scans have impli- cated DNA variants proximal to UBASH3A, which encodes a T-cell signaling- and activation-regulating protein [27], in the development of type 1 diabetes [28]. Thus, the ... See full document

5

Two stage strategies to detect gene × gene interactions in case control data

Two stage strategies to detect gene × gene interactions in case control data

... action effects between SNPs that provide some indication of marginal ...capture interactions with loci that have no mar- ginal effects, and as such is expected to be valid over a wider range of ... See full document

5

Host genotype by parasite genotype interactions underlying the resistance of anopheline mosquitoes to Plasmodium falciparum

Host genotype by parasite genotype interactions underlying the resistance of anopheline mosquitoes to Plasmodium falciparum

... quantitative genetic methods as the interaction effect in a statistical analysis between the parasite isolate and the mosquito family ...These methods are based on the idea that sibs are genetically ... See full document

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