[PDF] Top 20 ICP0 Is Required for Efficient Reactivation of Herpes Simplex Virus Type 1 from Neuronal Latency
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ICP0 Is Required for Efficient Reactivation of Herpes Simplex Virus Type 1 from Neuronal Latency
... wild-type herpes simplex virus type 1 (HSV-1), ICP0-null mutant viruses reactivate inefficiently from explanted, latently infected mouse trigeminal ganglia ... See full document
10
Phosphorylation Site Mutations Affect Herpes Simplex Virus Type 1 ICP0 Function
... including ICP0? Indeed, several studies indicate that cellular kinases most likely modulate the functions of IE proteins through ...ICP4 from residues 140 to 210 by protein kinase A appears to be ... See full document
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ICP0 Is Not Required for Efficient Stress-Induced Reactivation of Herpes Simplex Virus Type 1 from Cultured Quiescently Infected Neuronal Cells
... and required for herpes simplex virus type 1 (HSV-1) reactivation were identified using neuronally differentiated PC12 cells (ND-PC12 cells) in which quiescent ... See full document
9
Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene Promotes Neuronal Survival
... of latency is not yet ...of virus production and immediate-early gene expression at the level of mRNA pro- duction ...the virus to replicate in certain cell lines of neuronal and nonneuronal ... See full document
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A Herpes Simplex Virus Type 1 Latency-Associated Transcript Mutant with Increased Virulence and Reduced Spontaneous Reactivation
... is required for LAT function when LAT is not in its normal ...LAT from 1.5 to 8.3 kb. The StyI-StyI region may not be required in the context of the otherwise-complete LAT gene, but it is needed when ... See full document
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The herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latency.
... Herpes simplex virus type 1 establishes latent infections in sensory ...During latency only one locus, the latency-associated transcript (LAT), is abundantly ...is ... See full document
9
Herpes Simplex Virus Type 1 Latently Infected Neurons Differentially Express Latency-Associated and ICP0 Transcripts
... tected ICP0 transcripts not only in the TG and the SCG, which were positive by ISH, but also in other latently infected struc- tures such as the spinal cord and the ...of ICP0 transcripts is due to the slow ... See full document
12
A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation.
... of herpes simplex virus type 1 have a reduced capacity to reactivate following adrenergic induction in the rabbit eye ...a reactivation phenotype within LAT and describe the ... See full document
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Recruitment of the Transcriptional Coactivator HCF-1 to Viral Immediate-Early Promoters during Initiation of Reactivation from Latency of Herpes Simplex Virus Type 1
... HSV-1 reactivation. HCF-1 is an essential component of the HSV-1 IE regulatory ...after reactivation stimulation. (A) Schematic representation of the ICP0/LAT transcripts ... See full document
5
Nucleolin Is Required for an Efficient Herpes Simplex Virus Type 1 Infection
... derived from wt strains and correspond to viruses in which the ICP0 (dl110), ICP4 (HSV-1-17 Cgal delIE3), and ICP27 (HSV-1-KOS ...of ICP0 and ICP27 immediate-early genes ...cells ... See full document
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Role for Gamma Interferon in Control of Herpes Simplex Virus Type 1 Reactivation
... HSV-1 reactivation leading to detectable virus in ganglia was not seen in GKO and RGKO ...of reactivation in the IFN-g-incompetent mice, as detected by assay of viral antigens or infectious ... See full document
6
ICP0 Gene Expression Is a Herpes Simplex Virus Type 1 Apoptotic Trigger
... Human herpes simplex virus type 1 (HSV-1) is a large DNA virus (25) whose infection is characterized by the establishment of latency in neuronal cells (60) ... See full document
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Evidence that the herpes simplex virus type 1 uracil DNA glycosylase is required for efficient viral replication and latency in the murine nervous system.
... Assessment of the latent viral DNA burden by quantitative PCR QPCR demonstrated a reduction in the number of copies of the Ung- mutant viral Downloaded from http://jvi.asm.org/ on Novemb[r] ... See full document
10
Gamma Interferon Can Block Herpes Simplex Virus Type 1 Reactivation from Latency, Even in the Presence of Late Gene Expression
... Herpes simplex virus type 1 (HSV-1)-specific CD8 ⴙ T cells and the cytokine gamma interferon (IFN- ␥ ) are persistently present in trigeminal ganglia (TG) harboring latent ... See full document
9
The herpes simplex virus type 1 immediate-early protein ICP0 is necessary for the efficient establishment of latent infection.
... vitro neuronal model, establishment of latency is significantly influenced by mutations in the region of the ICP0 gene in a manner that is similar to the results obtained with in vivo models ... See full document
9
Evidence that the Herpes Simplex Virus Type 1 ICP0 Protein Does Not Initiate Reactivation from Latency In Vivo
... that ICP0 is not required for the earliest stages of reactivation (initiation of ...the ICP0 null mutant exited latency (initiated reactivation) as efficiently as the parental ... See full document
12
The latency-associated transcript gene of herpes simplex virus type 1 (HSV-1) is required for efficient in vivo spontaneous reactivation of HSV-1 from latency.
... In both experiments, the decreased spontaneous reactivation rate of the LAT deletion mutant compared with the parental or rescued virus was statistically significant McKrae versus dLAT29[r] ... See full document
11
In Vivo Knockdown of the Herpes Simplex Virus 1 Latency-Associated Transcript Reduces Reactivation from Latency
... neurons from apoptosis (9, 19) or cell death (20) during the later stages of the acute infection, as the virus establishes neuronal ...decreased reactivation of LAT mutants is a conse- quence ... See full document
10
Herpes Simplex Virus Type 1 Immediate-Early Protein ICP27 Is Required for Efficient Incorporation of ICP0 and ICP4 into Virions
... detect ICP0 and ICP4 in the tegument layer of WT ...pelleted from this material and purified by centrifugation through a 5 to 15% Ficoll 400 ...light-scattering virus band was ob- served, consistent ... See full document
10
The herpes simplex virus type 1 regulatory protein ICP0 enhances virus replication during acute infection and reactivation from latency.
... To compare the transactivating activities of ICPO mutant peptides with the reactivation frequencies of ICPO nonsense mutant viruses, ganglia latently infected with mutant and wild-type v[r] ... See full document
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