[PDF] Top 20 Second-Site Reversion of a Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutant That Restores Enzyme Function and Replication Capacity
Has 10000 "Second-Site Reversion of a Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutant That Restores Enzyme Function and Replication Capacity" found on our website. Below are the top 20 most common "Second-Site Reversion of a Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutant That Restores Enzyme Function and Replication Capacity".
Second-Site Reversion of a Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutant That Restores Enzyme Function and Replication Capacity
... of mutant and wild-type (WT) HIV-1 RTs was carried out after independent expression of their subunits (p66 and p51), by following a previously described procedure ...NaCl, 1 mM EDTA, 1 ... See full document
6
Reversion of a Human Immunodeficiency Virus Type 1 Matrix Mutation Affecting Gag Membrane Binding, Endogenous Reverse Transcriptase Activity, and Virus Infectivity
... the human immunodeficiency virus type 1 matrix (MA) protein that displayed reduced infectivity in single-round assays, defects in the stable synthesis of viral DNA in infected cells, ... See full document
10
Effects of zidovudine-selected human immunodeficiency virus type 1 reverse transcriptase amino acid substitutions on processive DNA synthesis and viral replication.
... this mutant during a single processive ...an enzyme-template-primer inter- action, although our data do not allow a conclusive choice to be made among the possible ...the mutant RT, defined as the ... See full document
8
Attenuated replication of human immunodeficiency virus type 1 with a didanosine-selected reverse transcriptase mutation.
... significant replication disadvantage and a loss of fitness to the virus in the absence of ...the mutant codon Val-74 reverts back to the WT codon ...RT. Reversion of single-nucle- otide ... See full document
7
Cross-Linking of the Fingers Subdomain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase to Template-Primer
... a function of template-primer size ...modified mutant RT, and the complex was irradiated with UV light to activate the pho- ...the second approach, an SH- linker was at- tached to specific positions ... See full document
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Individual Contributions of Mutant Protease and Reverse Transcriptase to Viral Infectivity, Replication, and Protein Maturation of Antiretroviral Drug-Resistant Human Immunodeficiency Virus Type 1
... Human immunodeficiency virus type 1 (HIV-1) variants resistant to protease (PR) and reverse transcriptase (RT) inhibitors may display impaired infectivity and ... See full document
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Relative Fitness and Replication Capacity of a Multinucleoside Analogue-Resistant Clinical Human Immunodeficiency Virus Type 1 Isolate with a Deletion of Codon 69 in the Reverse Transcriptase Coding Region
... binding site of the enzyme (e.g., Q151M) and with insertions or deletions in the  3-  4 hairpin loop in the finger subdomain (amino acid residues 56 to 77) of HIV-1 RT. The acquisition of ... See full document
9
Amino Acid Substitutions at Position 190 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Increase Susceptibility to Delavirdine and Impair Virus Replication
... increased replication capacity observed on G190X vi- ruses with the L74V mutation was relatively small compared to the respective patient-derived ...The replication capacity of recombinant ... See full document
12
A Second-Site Mutation That Restores Replication of a Tat-Defective Human Immunodeficiency Virus
... of function that is observed for the Y26A mutant may result from aberrant folding of the mutant protein and/or from a loss of interaction of Tat with either TAR RNA or cellular ...could ... See full document
9
Reversion of a human immunodeficiency virus type 1 integrase mutant at a second site restores enzyme function and virus infectivity.
... These results show that the P109S amino acid substitution induces the aggregation of recombinant HIV-1 integrase. The P109S protein was purified under denaturing conditions and was subsequently refolded. The P109S ... See full document
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Reversion of a Moloney murine leukemia virus RNase H mutant at a second site restores enzyme function and infectivity.
... the virus, we subcloned this region from the cloned fragment of the revertant viral DNA back into pNCA, a plasmid containing a cloned copy of wild-type M- MuLV proviral DNA ...by site-directed ... See full document
5
Mutations in the Thumb Allow Human Immunodeficiency Virus Type 1 Reverse Transcriptase To Be Cleaved by Protease in Virions
... Although human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) has been extensively studied, there are still significant questions about the ... See full document
9
Comparison of Sequencing by Hybridization and Cycle Sequencing for Genotyping of Human Immunodeficiency Virus Type 1 Reverse Transcriptase
... in virus isolates from PBMCs, but virus isolation is neither recommended nor preferred over direct testing of plasma HIV-1 ...from virus isolate-infected cul- tured cell DNA have yielded ... See full document
7
Human Immunodeficiency Virus Type 1 Subtype F Reverse Transcriptase Sequence and Drug Susceptibility
... Most human immunodeficiency virus type 1 (HIV-1) drug susceptibility studies have involved subtype ...nonnucleoside reverse transcriptase (RT) inhibitors (8), as is ... See full document
5
Resistance pattern of human immunodeficiency virus type 1 reverse transcriptase to quinoxaline S-2720.
... Indeed, the quinoxaline derivative has broad-spectrum activity against various mutant HIV-1 strains that are resistant to other HIV-1-specific RT inhibitors; i.e., quinoxaline S-2720 is [r] ... See full document
7
Analysis of nonnucleoside drug-resistant variants of human immunodeficiency virus type 1 reverse transcriptase.
... not, by themselves, appear to be important in determining the sensitivity of HIV-1 RT to TBA, HEPT, or calanolide A, it is still possible that these substitutions could have an effect if[r] ... See full document
9
Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors.
... 4887 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Human immunodeficiency virus type 1 HIV-1-specific pyridinone reverse transcriptase RT inhibitors prevent HIV-1 rep[r] ... See full document
6
Human Immunodeficiency Virus Mutagenesis during Antiviral Therapy: Impact of Drug-Resistant Reverse Transcriptase and Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors on Human Immunodeficiency Virus Type 1 Mutation Frequencies
... catalytic site plays a key role in inducing template-primer slippage for ⫺ 1, ⫺ 2, and ⫹ 1 frameshift mutations and dislocation mutagenesis of HIV-1 RT ...DNA replication fidelity are ... See full document
13
Inhibition of Human Immunodeficiency Virus Type 1 Replication prior to Reverse Transcription by Influenza Virus Stimulation
... influenza virus (A/Bangkok/RX73 and A/Puerto Rico/8/34 strains; 1:800) or with the 1998–1999 formula of influenza virus vaccine (1:5,000; Wyeth Laboratories ...influenza virus vaccine ... See full document
7
Inhibition of recombinant human immunodeficiency virus type 1 replication by a site-specific recombinase.
... that site-specific recombinases can potentially contribute to genetic targeting of HIV and may facilitate gene correction strategies in other human ... See full document
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