[PDF] Top 20 Herpes Simplex Virus Type 2 (HSV-2) Establishes Latent Infection in a Different Population of Ganglionic Neurons than HSV-1: Role of Latency-Associated Transcripts
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Herpes Simplex Virus Type 2 (HSV-2) Establishes Latent Infection in a Different Population of Ganglionic Neurons than HSV-1: Role of Latency-Associated Transcripts
... chimeric HSV-2 mutant that expresses the HSV-1 LAT (HSV-2 333/ LAT1) establishes latency primarily in A5-positive neurons, similar to ...the latency ... See full document
7
The herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latency.
... Herpes simplex virus type 1 establishes latent infections in sensory ...During latency only one locus, the latency-associated transcript (LAT), is ... See full document
9
Influence of Herpes Simplex Virus 1 Latency-Associated Transcripts on the Establishment and Maintenance of Latency in the ROSA26R Reporter Mouse Model
... of HSV-1 ...of infection or for reactivation from latency (15, 36, ...for latency establishment, sug- gesting that the LATs function during entry into latency, rather than ... See full document
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Herpes Simplex Virus Type 1 Latency-Associated Transcript Expression Protects Trigeminal Ganglion Neurons from Apoptosis
... Upon infection of murine trigeminal ganglia with herpes simplex virus type 1 (HSV-1), an immune response is initiated resulting in significant infiltration of CD8 ⴙ ... See full document
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In vivo deletion analysis of the herpes simplex virus type 1 latency-associated transcript promoter.
... as neurons of the peripheral nervous system in which HSV establishes a latent infection, and thus these cell lines may vary considerably in the quantity and specificity of their ... See full document
7
The abundant latency-associated transcripts of herpes simplex virus type 1 are bound to polyribosomes in cultured neuronal cells and during latent infection in mouse trigeminal ganglia.
... primary infection, herpes simplex virus type 1 (HSV-1) colonizes the human peripheral sensory ganglia (PSG), establishes latent infection, and ... See full document
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Quantitation of herpes simplex virus type 1 DNA and latency-associated transcripts in rabbit trigeminal ganglia demonstrates a stable reservoir of viral nucleic acids during latency.
... with HSV-1 strain McKrae or 17Syn 1 and at least 80% of the eyes of these rabbits undergo ocular reactivation from 20 to 360 days fol- lowing ...of virus from eye swabs and/or recurrent ... See full document
5
Evidence that two latency-associated transcripts of herpes simplex virus type 1 are nonlinear.
... establish latent infections in their natural hosts (reviewed in reference ...productive infection near the portal of entry, human herpes simplex virus type 1 ... See full document
6
Herpes Simplex Virus Type 1 Latently Infected Neurons Differentially Express Latency-Associated and ICP0 Transcripts
... the latent phase of herpes simplex virus type 1 (HSV-1) infection, the latency-associated transcripts (LATs) are the most abundant viral ... See full document
12
Two herpes simplex virus type 1 latency-active promoters differ in their contributions to latency-associated transcript expression during lytic and latent infections.
... the 2-kb LAT with the 39 ter- minus of the ICP0 mRNA suggests that LAT may function as an antisense inhibitor of the translation of ICP0, an immedi- ate-early gene critical for reactivation from ...a role ... See full document
10
Long-term expression in sensory neurons in tissue culture from herpes simplex virus type 1 (HSV-1) promoters in an HSV-1-derived vector.
... defective herpes simplex virus type 1 (HSV-1) vectors, were constructed to use four HSV-1 promoters, from the immediate-early (IE) 1 IE 3, IE 4/5, and ... See full document
8
Mutational analysis of the virion host shutoff gene (UL41) of herpes simplex virus (HSV): characterization of HSV type 1 (HSV-1)/HSV-2 chimeras.
... rather than one encoding chloramphenicol ...FIG. 1. Construction of p333. The UL41-containing NotI-NsiI fragment from HSV-2(333) was excised from plasmid pKC7BglN and inserted between the ... See full document
10
The Latency-Associated Transcript Inhibits Apoptosis via Downregulation of Components of the Type I Interferon Pathway during Latent Herpes Simplex Virus 1 Ocular Infection
... and 1-bromo-2 chloropropane (BCP) as described previously ...leukemia virus (MuLV) reverse transcriptase from a high-capacity cDNA reverse transcription kit (Applied Biosystems, Foster City, CA), ... See full document
16
Regional Distribution of Antibodies to Herpes Simplex Virus Type 1 (HSV 1) and HSV 2 in Men and Women in Ontario, Canada
... Herpes simplex virus type 2 (HSV-2) is a sexually transmit- ted virus that is the most common cause of genital ulceration ...genital herpes in pregnant women ... See full document
6
Peptide sequences of glycoprotein G-2 discriminate between herpes simplex virus type 2 (HSV-2) and HSV-1 antibodies.
... with HSV-2 antigen, in attempts to improve HSV-2 IgG ...signals than those obtained with peptide G2-69 ...better than the antigen, while the antigen catches the remaining gG- ... See full document
5
A 371-nucleotide region between the herpes simplex virus type 1 (HSV-1) LAT promoter and the 2-kilobase LAT is not essential for efficient spontaneous reactivation of latent HSV-1.
... parental virus because its high spontaneous-reactivation rate in rabbits allows changes in the spontaneous-reactivation rates of mu- tants to be detected and analyzed statistically (16, ...of HSV-1 ... See full document
5
Gamma Interferon Can Prevent Herpes Simplex Virus Type 1 Reactivation from Latency in Sensory Neurons
... primary HSV-1 infection (4, 16, ...is associated with the presence of the cyto- kines IFN-␥, tumor necrosis factor alpha, and interleukin-6, suggesting persistent activation of the ... See full document
7
Functional Comparison of Herpes Simplex Virus 1 (HSV-1) and HSV-2 ICP27 Homologs Reveals a Role for ICP27 in Virion Release
... WT HSV-1 infection, in order to establish to what degree progeny virions are intracellular versus extracellular at the com- pletion of ...that HSV-1 virions are readily inactivated by ... See full document
14
Role of the virion host shutoff (vhs) of herpes simplex virus type 1 in latency and pathogenesis.
... during infection by herpes simplex virus type 1 (HSV-1) requires the coordinated regulation of all three temporal classes of viral genes: immediate-early ( a ), ... See full document
8
Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene Promotes Neuronal Survival
... sensory neurons is also not ...in neurons in mouse ...of infection and thought to be an immune regulatory process (4, 24, ...of neurons and only one or a very few virions enter any particular ... See full document
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