[PDF] Top 20 Testing gene environment interactions in gene based association studies
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Testing gene environment interactions in gene based association studies
... genetic association studies faces many challenges that are well known in the field, such as issues of computational burden, model dependency, and multiple testing ...of gene-environment ... See full document
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Genetic polymorphisms in PTPN22, PADI 4, and CTLA 4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene environment interactions with heavy cigarette smoking
... DNA was extracted from buffy coats from 96 samples in 3 to 4 hours. A volume of 50 μl of buffy coat was diluted with 150 μl phosphate-buffered saline and processed using the QIAmp™ (QIAGEN Inc., Chatsworth, CA, USA) ... See full document
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Quantile regression analysis reveals widespread evidence for gene-environment or gene-gene interactions in myopia development
... GxE interactions will Table 1 Summary statistics for the 10 strongest associations with refractive error based on conditional quantile regression-meta- regression ... See full document
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Grid-based stochastic search for hierarchical gene-gene interactions in population-based genetic studies of common human diseases
... A common approach for addressing overfitting in data mining and machine learning is to use cross-validation as an estimate of the generalizability of a model. Unfortunately, implementation of cross-validation methods in ... See full document
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A gene based approach for testing association of rare alleles
... Genome-wide association studies (GWAS) have been promising for identifying the underlying genetic basis of complex ...the association of rare genetic variants because of low allele counts in a ...the ... See full document
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Gene-gene and gene-environment interactions: new insights into the prevention, detection and management of coronary artery disease
... an association signal above background noise ...of gene-gene investigations resulting from their higher measurement accuracy is diminished by the need to correct for multiple comparisons and by the ... See full document
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Discovering pure gene environment interactions in blood pressure genome wide association studies data: a two step approach incorporating new statistics
... Gene-environment interactions (G × E) have long been known to play an important role in complex disease ...family-based association studies ...of gene and ... See full document
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An investigation of gene-gene interactions in dose-response studies with Bayesian nonparametrics
... how gene-gene interactions can affect the ability to detect trait-associated loci in cell-based, dose-response association ...genetics based analysis, we have shown that MANOVA ... See full document
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Gene-environment interactions involving functional variants: Results from the Breast Cancer Association Consortium
... participating studies were centrally cleaned and ...case-control studies this was defined as the date of diagnosis for cases and the date of questionnaire for controls, and in the three cohort ... See full document
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A new gene based association test for genome wide association studies
... multiple testing because we are doing around 20,000 tests instead of half a ...the gene-based test will be more powerful than the SNP-based test ...the gene-based test presents ... See full document
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Comparison of 2 models for gene–environment interactions: an example of simulated gene–medication interactions on systolic blood pressure in family based data
... MERLIN, based on the framework of available high- density genome-wide SNP data ...data based on the observed longitudinal data in the family-based sam- ...simulated gene–medication in- ... See full document
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Gene-environment interactions involving functional variants: Results from the Breast Cancer Association Consortium.
... participating studies were centrally cleaned and ...case-control studies this was defined as the date of diagnosis for cases and the date of questionnaire for controls, and in the three cohort ... See full document
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Gene-Environment Interactions and Airway Disease in Children
... is based on the statistical probability that cosegregation is unlikely to happen by ...Linkage studies have identified sev- eral areas of chromosomes that segregate with the asthma phenotype and may carry ... See full document
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Gene based bin analysis of genome wide association studies
... genome-wide association studies. This algorithm is based on a gene-based partitioning of DNA into regions, called ...of association is computed for each ...multiple ... See full document
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Original Article Methylenetetrahydrofolate reductase gene A1298C polymorphism and gene-environment interactions are associated with carotid plaque in a south Chinese population
... previous studies 8, ...mechanisms. Studies have demonstrat- ed that current smokers were more likely to have plaques when compared to those who have never smoked ...4. Association of MTHFR ... See full document
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A partition based approach to identify gene environment interactions in genome wide association studies
... Genome-wide association studies (GWAS) have success- fully discovered many common variants associated with complex diseases, but the single-nucleotide polymorph- isms (SNPs) identified so far account for a ... See full document
5
Gene Environment Interactions in Asthma: Genetic and Epigenetic Effects
... asthma, exercise-induced asthma, and menstruation- or obe- sity-associated asthma. Inflammatory patterns on sputum analysis have revealed eosinophilic, neutrophilic, and pauci- granulocytic types of asthma. Therefore, ... See full document
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Comparison of the power of haplotype based versus single and multilocus association methods for gene × environment (gene × sex) interactions and application to gene × smoking and gene × sex interactions in rheumatoid arthritis
... both with sex and with smoking was found (lowest adjusted p-values of 0.02 and <0.001, respectively). Six common haplotypes with frequencies ≥ 5% were esti- mated in PTPN22 (Table 5). Applying the haplotype-trait ... See full document
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Rule based classifier for the analysis of gene-gene and gene-environment interactions in genetic association studies
... rule based classifier approach could quickly generate testable hypotheses for additional ...rule based classifiers are an important addition to the armamentarium of tools available for analyses of complex ... See full document
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The clinical application of UGT1A1pharmacogenetic testing: Gene-environment interactions
... Therefore, testing for the presence of the UGT1A1 reduced activity poly- morphism can provide invaluable information on the potential for either drug toxicity or efficacy when prescribing certain drugs (Table ... See full document
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