[PDF] Top 20 Tetrameric Ring Formation of Epstein-Barr Virus Polymerase Processivity Factor Is Crucial for Viral Replication

... the viral DNA polymerase processivity factor, playing an essential role in lytic replication (7, 16, 25, 26, 29, ...and formation of replication ...Lytic ... See full document

... EBV replication compart- ments has revealed that BMRF1 cores, where BMRF1 protein is enriched, constitute subnuclear domains inside the replication compartment ...BALF5 polymerase catalytic subunit ... See full document

... inhibit replication of herpes simplex virus (HSV) and varicella-zoster virus (VZV) ...HCMV replication by a novel mechanism: although viral DNA synthesis is inhibited, the HCMV DNA ... See full document

... cullin ring ligases, potentially affecting viral replication and infectivity (13, 25, ...the viral DUB activity antagonizes RIG-I signaling during KSHV infection ...lymphoma formation ... See full document

... Epstein-Barr virus (EBV) productive DNA replication occurs at discrete sites, called replication compart- ments, in ...the replication compartments during lytic infection. The ... See full document

... as Epstein-Barr virus (EBV), Ka- posi’s sarcoma-associated herpesvirus (KSHV), and murine gammaherpesvirus 68 (MHV-68), are associated with various ma- lignancies and lymphoproliferative disorders ... See full document

... DNA polymerase (BALF5) mRNA is unusual in having two potential cleavage and polyadenylation sites, and SM has been shown to facilitate the processing of this RNA transcript ...DNA replication after com- ... See full document

... of Epstein-Barr virus (EBV), binding of the trans- activator Zta to the origin of lytic replication (oriLyt) and the BHLF1 transcript, form- ing a stable RNA-DNA hybrid, is required to ... See full document

... host factor for the nuclear trans- fer of EBV DNA ...in Epstein-Barr virus-positive NK/T-cell lymphoma cells by Akt downregulation ...DNA replication by the Hsp90 inhibitor may be due ... See full document

... productive viral replication, the EBV genome is amplified 100- to 1,000-fold by viral replication machinery composed of BALF5 DNA polymerase (Pol), BMRF1 polymerase ... See full document

... The Epstein-Barr virus (EBV) glycoprotein gp110 has substantial amino acid homology to gB of herpes simplex virus but localizes differently within infected cells and is essentially ... See full document

... inhibit viral gene expression but decreases EBV ...switches viral gene expression from latent program to lytic program, we examined whether the loss of BZLF1 inhibitory activity in the TNF- ␣ ... See full document

... containing viral replication compartments, SRp20 localized to nodules at the surface of viral replication ...splicing factor and mRNA export factor SRp20 is recruited to VINORCs ... See full document

... Some authors 1, 27 recently reported that induced or uninduced Raji cells do not contain any DNA polymerase activity and concluded that the lack of this enzyme is the reason for the inca[r] ... See full document

... lytic replication of the virus in cell ...lytic replication and thus may be involved in stabilizing viral latency, which is in accordance with the early regulation during the lytic ...lytic ... See full document

... the replication timing and chromatin organiza- tion of ...early replication origins ...that replication timing was important for genome stability during S phase (12, ...early replication ... See full document

... in replication. Involvement of cellular or viral proteins in the process of EBV replication was previously assessed using a cotransfection replication assay employing a plasmid containing ... See full document

... DNA replication by transfected polymerase and primase allowed us to examine whether late genes were acti- vated solely by DNA ...DNA replication alone in the absence of ...DNA replication per ... See full document

... Although region I is required for the transient replication of plasmids bearing region II in EBV-infected B cells, a plasmid lacking region I but containing region II, was observed to re[r] ... See full document

... For viral protein detection, tissues were probed with a poly-HRP secondary antibody (Invitrogen) and subsequently subjected to tyramide signal amplification (TSA) according to the manufacturer’s instruc- tions ... See full document