[PDF] Top 20 Trial Sequential Analysis in systematic reviews with meta-analysis

... single trial and in a meta-analysis of several trials lies in two basic ...the trial is the difference between the ...small trial and a small meta-analysis, the ... See full document

... this meta-analysis to evaluate the specific role of this ...Subgroup analysis were performed to evaluate the specific role of rs138213197 in disease aggressiveness, diagnostic age and family ... See full document

... tsa/. For dichotomous outcomes, we will estimate the required information size based on the observed propor- tion of patients with an outcome in the control group (the cumulative proportion of patients with an event in ... See full document

... relevant trial sequential monitoring boundaries, the required information size for the primary dichotomous outcomes will be based on type I error of 5%, a beta of 10%, the proportion of patients in the ... See full document

... Balneotherapy, 1 has been frequently used globally as a complementary and/or alternative therapy. 2 – 5 A recent systematic review (SR) showed that balneotherapy (BT) and spa therapy (ST) could signi fi cantly ... See full document

... We judged whether the review authors adhered to GRADE guidance for downgrading or non-downgrading evidence for imprecision. To determine whether the imprecision evaluation was appropriate (e.g., expected and observed ... See full document

... Our meta-analysis showed similar results with SPLIT (9) and SMART (10) studies regarding to comparisons between balanced crystalloid fluid versus ...subgroup analysis or when removing each single ... See full document

... a meta-analysis if two or more studies assess similar populations, utilize analogous methods, have related study designs, and evaluate similar ...from systematic reviews for the association ... See full document

... Articles were scored against the 27 checklist items de- scribed in the PRISMA 2009 statement [16] by two inde- pendent researchers (H.S., and R.F.). Each item was weighted equally, and the same number of denominators was ... See full document

... Cochrane systematic reviews, which means that other non-Cochrane systematic reviews might have been published between updates and these could have influenced the perceived need for ...our ... See full document

... A systematic search of database was performed to retrieve studies of published human studies and trials from 1995-2012, concentrating on recent systematic reviews, meta-analysis and ... See full document

... Pooled meta- analytic results were extracted ...atic reviews without meta-analysis, it is possible that multiple results from multiple studies are ...descriptive systematic ... See full document

... 5 Trial sequential analysis of the effect of dexmedetomidine on the prevention of emergence agitation in adults compared with ...the trial sequential monitoring ... See full document

... Current meta-analysis was reported in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses Guideline. Comprehensive searches includ- ing electronic ... See full document

... relevant systematic reviews have assessed the clinical effectiveness or the risk of paediatric massage therapy, in this study, a meta-analysis was conducted to assess the efficacy of ... See full document

... for systematic reviews and primary research from 1990 in August 2011 using several sources, including specialist registers [Cochrane Database of Systematic Reviews (CDSR), The Campbell ... See full document

... this systematic review may be lim- ited by the fact that we did not search for unpublished ...a trial sequential analysis methodology to con- trol the risk of false-positive results in ... See full document

... conventional meta- analyses still report statistically significant ...ADDS: Trial sequential analysis reveals that conclusions from conventional meta- analysis about hypertonic ... See full document

... this meta-analysis using a comprehensive search of Cochrane Database of Systematic Reviews, PubMed, MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials till 15 March 2018 for ... See full document

... Random-effects meta-analysis and trial sequential analysis (TSA) was used for the primary outcome; and meta-analysis for secondary ...subgroup analysis of studies ... See full document