6-thioguanine
Au Nanoparticle Loaded with 6-Thioguanine Anticancer Drug as a New Strategy for Drug Delivery
... Although, 6-TG was suggested as a useful anti-cancer drug it showed many side effects in the human body such as black, tarry stools, fever or chills, unusual bleeding or bruising, cough or hoarseness and pinpoint ...
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MUTYH mediates the toxicity of combined DNA 6-thioguanine and UVA radiation
... photosensitizer 6-thioguanine (6-TG) in the DNA of the patients’ ...DNA 6-TG and UVA are synergistically cytotoxic and their interaction causes oxidative ...enhanced 6-TG/UVA resistance ...
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The Effect of 6-Thioguanine on Proliferation, Viability and Expression of the Genes DNMT 3A, DNMT 3B and HDAC3 in Lymphoid Cancer Cell Line Nalm6
... HDACs generally induce differentiation in the tumor cells, inhibit cellular oscillation in the G0/G1 or G2/M stage, and activate apoptotic genes, which depend on the type of cell (30). In 2001, it is reported that HDACs ...
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<p>Transcriptomics Analysis of the Tumor-Inhibitory Pathways of 6-Thioguanine in MCF-7 Cells via Silencing DNMT1 Activity</p>
... Additionally, 6-TG decreased DNMT1 expression levels in leukemic cells by inducing the proteasome-mediated degradation of ...33 6-TG is known to cause DNA damage and accumulating DNA strand breaks, ...
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BROMODEOXYURIDINE-INDUCED MUTATIONS IN SYNCHRONOUS CHINESE HAMSTER CELLS: TEMPORAL INDUCTION OF 6-THIOGUANINE AND OUABAIN RESISTANCE DURING DNA REPLICATION
... Mutations were induced in synchronous Chinese hamster cells by bromo- deoxyuridine (BUdR) incorporated into cells for one-hour periods in the cell cycle.. There was a very[r] ...
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The Queuine Transfer RNA Pathway as a novel drug mechanism to treat Multiple Sclerosis
... This study shows that the queuine analogue 6-thioguanine 6TG can influence immune function when incorporated into tRNA via the queuine-tRNA pathway and furthermore, that this is an effec[r] ...
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Theoretical Survey on Tautomerism of Thioguanine Tautomers by Polarisable Continuum Method (PCM)
... 6-Thioguanine (SG) is a known anti- cancer agent that is readily incorporated in place of guanine during DNA replication. The incorporation of SG nucleotides into DNA and RNA by polymerases can lead to cell ...
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Monitoring Thiopurine Metabolites in Korean Pediatric Patients with Inflammatory Bowel Disease
... and 6-thioguanine nucleotide (6-TGN) as predictors of clinical response and side effects to azathioprine (AZA), and estimate the optimal AZA dose in Ko- rean pediatric inflammatory bowel disease ...
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Selection of Morphologically Normal Cell Lines from Polyoma-transformed BHK21/13 Hamster Fibroblasts
... Frequenicy of transformed and normal cells in sublines derived from Hy3-5 survivors to 6-thioguanine Platingc efficiency Plating efficiency in agar medium of viable cells b/a X 100 Expt.[r] ...
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The first cases of collagenous sprue successfully treated with thioguanine
... al 6 described that half of the patients responded to treatment with steroids and a gluten-free diet ...malnutrition. 6 7 Thioguanine (6-TG) is a purine analogue that belongs to the thiopurine ...
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Vol 6, No 6 (2015)
... Since the students of the National University of Lesotho (NUL) speak mostly Sesotho at home and among themselves, some of them hardly utter English words and phrases outside the classro[r] ...
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Vol 6, No 6 (2015)
... Regarding learning activities, 18 item scores (86%) indicated a poor level of autonomy among low-motivation students, whereas only seven items (33%) had average scores, r[r] ...
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Vol 6, No 6 (2020)
... Therefore, motor fitness, perception, cognition is important elements for the ability to batting, bowling, wicket keeping and fielding. On the other hand, successful ‘running between the wickets’ depends on efficient ...
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Vol 6, No 6 (2020)
... Research findings showed that there is a significant difference in the level of learning the ball skill between Pet Lep mental imagery group and traditional illustration group a[r] ...
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Vol 6, No 6 (2020)
... It was understood from the result that experimental treatments of different recreational games training significantly improved hand eye co-ordination and gross movement of h[r] ...
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Vol 6, No 6 (2020)
... Moreover, the Department of Education (DepEd) and the Commission on Higher Education (CHED) in the Philippines must put vision accounts on ASEAN folk dances to be part of edu[r] ...
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Vol 6, No 6 (2015)
... Design phase of Bahasa Indonesia learning materials based on folklore on III grade learner in the primary school has many design activities; such as (a) designing the syllabus; [r] ...
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Vol 6, No 6 (2015)
... Mehmet Cem Odacıoğlu was born on July 6, 1985 in Konya in Turkey. He earned his B.A..from english translation and interpretation department at Atılım University and M.A. in translation studies from Hacettepe ...
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Vol 6, No 6 (2015)
... The total length of the recorded corpus (the forty-nine doctor-patient oral interactions) is about 6 hours. Moreover, the shortest one is 161 seconds and the longest one is 460 seconds. The writer selects 15 ...
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Vol 6, No 6 (2015)
... In conclusion, pragmatic competence is one of the aims of college English teaching and should be integrated with the cultivation of linguistic competence. The above-mentioned methods of[r] ...
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