Complex Traits
Epigenetic prediction of complex traits and death
... The GS cohort contained related individuals who may be more phenotypically similar for the traits under investiga- tion. Residuals from sensitivity analyses that adjusted the phenotypes for pedigree structure as a ...
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A Systems Genetics Approach to the Dissection of Complex Traits in Drosophila melanogaster.
... about complex traits in terms of polygenetic factors (Thoday ...of complex traits was, indeed often complex, underlined by several interacting ...polygenic traits at the genome ...
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A Fast Algorithm for Functional Mapping of Complex Traits
... By integrating the underlying developmental mechanisms for the phenotypic formation of traits into a mapping framework, functional mapping has emerged as an important statistical approach for mapping ...
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Multi-level convergence of complex traits and the evolution of bioluminescence
... characterizing complex trait systems at the cellular, subcellular, and molecular ...convergent traits. Conversely, we can study multiple levels of convergent traits to understand how constraints led ...
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Linkage mapping for complex traits : a regression-based approach
... do with the nature of the linkage mapping process which usually involves two stages: following a first low-density scan, higher-density genotyping is carried out in one or several promising regions. In this case, IBD ...
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Next-Generation Mapping of Complex Traits with Phenotype-Based Selection and Introgression
... PSIseq has additional advantages. First, the experimental replication needed to increase mapping resolution can be spaced out over time, and population sizes within a replicate need only be large enough to maintain the ...
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A Simple Test Identifies Selection on Complex Traits
... important traits or for identifying loci that are under selection are most power- ful for large-effect ...that complex traits are often controlled by many genes of small effect (Yang et ...studying ...
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Prediction of genetic contributions to complex traits using whole genome sequencing data
... to complex traits is the use of whole genome markers jointly ...for complex traits in humans, as compared to prediction using only specific susceptibil- ity loci from GWAS ...
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Deleterious Mutation Burden and Its Association with Complex Traits in Sorghum (Sorghum bicolor)
... agronomic traits, dry biomass (DBM) and plant height (PH), and for two physiological traits, specific leaf area (SLA) and tissue starch content (TSC), under field ...of complex traits and, if ...
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Properties and Power of the Drosophila Synthetic Population Resource for the Routine Dissection of Complex Traits
... Different types of mapping designs have different advan- tages depending on the nature of the genetic variation underlying a phenotype. Rare alleles are statistically very difficult to detect via genome-wide association ...
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Genetic and Environmental Effects on Complex Traits in Mice
... when complex traits are measured in the mouse, but the magnitude of that interaction has not often been ...88 complex traits that include models of human disease (asthma, type 2 diabetes ...
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Genetic strategies for dissecting complex traits in biomass willows (Salix spp.)
... biomass traits in willow for more targeted breeding via marker-assisted ...dissect complex traits into more defined components for molecular breeding and gene ...
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On the SNP-based and Sequence-based Whole Genome Studies for Complex Traits.
... association signals are gaining momentum in the literature. Although originally developed to achieve a better balance between retaining information and controlling degrees of freedom when performing multimarker ...
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Across-cohort QC analyses of GWAS summary statistics from complex traits
... Genome-wide association studies (GWASs) have been successful in discovering SNP trait associations for many quantitative traits and common diseases. Typically, the effect sizes of SNP alleles are very small and ...
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A New Approach to the Problem of Multiple Comparisons in the Genetic Dissection of Complex Traits
... Seven milk production traits were analyzed for 128 markers in the U.S. Holstein population. i, number of null hypothesis ranked by descending P ; SCS, somatic cell score; Chromosome, bovine chromosome number; ...
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Efficient algorithms for multidimensional global optimization in genetic mapping of complex traits
... quantitative traits. Such traits are believed to be affected by multiple so called quantitative trait loci (QTL), and searching for d QTL results in a d-dimensional optimization problem with a large number ...
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Evaluating epistatic interaction signals in complex traits using quantitative traits
... quantitative traits underlie complex phe- notypes and contain more information on the trait variation within genotypes than qualitative dichotomy, analyzing quantitative traits correlated with the ...
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Identification of genes associated with complex traits by testing the genetic dissimilarity between individuals
... In this study, we use the data set with 697 unrelated indi- viduals provided by GAW17 to conduct the gene-based analysis. The genotypes, sex, and population data of these individuals are from the 1000 Genomes Project ...
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Evidence for sex specific genetic architectures across a spectrum of human complex traits
... quantitative traits did not lead to spurious genetic correlations below one, we performed an additional analysis on rank normal- ized phenotypes (Additional file 1: Additional methods and ...of traits with ...
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Assessment of a new strategy for selective phenotyping applied to complex traits in Brassica napus
... include several hundred genes [1,2]. These large support intervals are a major limitation to the use of QTL in breeding programs through marker-assisted selection (MAS). Indeed, the larger the support interval, the ...
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