dimer interface
The Influence of Dimer Interface Mutations Upon the Folding and Activity of Procaspase-3
... the dimer interface in the caspase-3 ...the dimer interface (Figure 22A). Loop L3 inserts next to the dimer interface with the “elbow loop” containing the proline ...
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Human Immunodeficiency Virus Type 1 Gag Polyprotein Multimerization Requires the Nucleocapsid Domain and RNA and Is Promoted by the Capsid-Dimer Interface and the Basic Region of Matrix Protein
... hydrophobic dimer interface ...the dimer in- terface mutants are associated with a fourfold reduction in virion assembly (23); this result correlates with the magnitude of the reduction of Gag-Gag ...
14
Structure, Folding, and Assembly of (Pro)caspase-3. The Role of the Dimer Interface in Active Site Formation.
... the dimer, though, we suggest a more direct role in maintaining the active site ...of dimer stability in the K242A, E246A variant; however, a decrease in activity (or a complete loss in ...
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The importance of the dimer interface in the folding and assembly of procaspase-3.
... The dimer interface of caspase–8 contains only two main-chain hydrogen bonds, and these occur between the backbone amide of Phe468 and the carbonyl oxygen of Pro466 as well as the symmetry-related ...
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Redesigning Procaspase-8 Dimer Interface Improves Dimerization.
... at the N-terminal might provide the right comformer for caspase-8 to bind. These results can also explain why the activity of procaspase-8 is decreasing in higher sodium citrate. When HEK293A cells are transfected with ...
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Quantitative Comparison of Human Parainfluenza Virus Hemagglutinin-Neuraminidase Receptor Binding and Receptor Cleavage
... the dimer inter- face ...the dimer interface and confers the ability to bind RBCs in the presence of N-site inhibitors (18, 19), suggesting that the increased H avidity is the result of a secondary ...
9
Structural Basis of Ligand Interactions of the Large Extracellular Domain of Tetraspanin CD81
... antiparallel dimer (29, ...The dimer interface is controversial, since mutation of interfacial residues seen in the crystal does not affect oligomerization of intact CD81 in mammalian cells ...
11
THE RHETORIC OF REFUGEES: LITERACY, NARRATIVE AND IDENTITY FOR SOMALI WOMEN
... The crystal structure of choline oxidase in complex with glycine betaine has highlighted the importance of the dimer interface in controlling substrate access to the active site, while s[r] ...
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A ligand-binding pocket in the dengue virus envelope glycoprotein
... sE dimer (Fig. 2). In TBE, its homolog extends laterally across the dimer interface and ‘‘covers’’ the fusion peptide (residues 100– 108) on domain II of the dimer ...the dimer by the ...
7
Structure-Based Mutational Analysis of the C-Terminal DNA-Binding Domain of Human Immunodeficiency Virus Type 1 Integrase: Critical Residues for Protein Oligomerization and DNA Binding
... the dimer interface of the C-terminal domain results in a reduction of tetramer formation and subsequently in decreased IN activity (this study), and (iii) the functionally related MuA transposase is active ...
8
Identification of novel modulators for ionotropic glutamate receptor, iGluA2 by in-silico screening
... the dimer interface of iGluA2-LBD, and the binding mode of these compounds are essentially similar to the known established compounds such as cyclothiazide (CTZ), IDRA-21 and benzothiadiazide derivatives of ...
11
Asymmetric kinase dimer formation is crucial for the activation of oncogenic EGFRvIII but not for ERBB3 phosphorylation
... that stably express EGFRvIII-V948R indicating the functional role of asymmetric kinase dimer formation (Figure 4C: ii). EGFRvIII-V948R however failed to trans- form Ba/F3 cells that expressed ERBB3-V945R even ...
7
Importance of the N Terminus of Rous Sarcoma Virus Protease for Structure and Enzymatic Function
... the dimer apart by competition (3, 36, ...to dimer- ize probably is due to the loss of backbone and side chain contacts between the N-terminal sequence of one subunit and the C-terminal sequence of the ...
10
Dimer dimer stacking interactions are important for nucleic acid binding by the archaeal chromatin protein Alba
... Alba dimer for every 6 bp of dsDNA bound, suggesting a high binding density ...conserved dimer–dimer interface centred on the Phe 60 residue, which stacks with its counterpart in ...
7
Structural insights into the function of type VI secretion system TssA subunits.
... In the assembled Bc TssA1B CTD ring, analysis by PISA32 revealed an extensive dimer interface ~950 Å2 between monomers in the different layers, which principally involves the interaction[r] ...
17
PubMedCentral-PMC5123051.pdf
... The rapid spread of Zika virus (ZIKV), which causes microcephaly and Guillain-Barre ´ syndrome, signals an urgency to identify therapeutics. Recent efforts to rescreen dengue virus human antibodies for ZIKV ...
7
PubMedCentral-PMC4725519.pdf
... monomer interface as the native SOD1 ...SOD1 dimer interface are spread into discrete re- gions on each monomer, with a significant fraction solvent-exposed in the SOD1 trimer (Movie ...native ...
6
The Dimer Interfaces of Protease and Extra-Protease Domains Influence the Activation of Protease and the Specificity of GagPol Cleavage
... This conclusion is supported by results reported by others. Several groups have examined the processing of constructs containing the protease with extensions into GagPol of various lengths. Wondrak et al. (54) evaluated ...
9
Structure of the WipA protein reveals a novel tyrosine protein phosphatase effector from Legionella pneumophila
... observed dimer interface is not mediated by interactions between the coiled-coil regions of two WipA molecules may thus indicate that the WipA dimer might be rather weak and that WipA might be able ...
14
Structural evidence for Arabidopsis glutathione transferase AtGSTF2 functioning as a transporter of small organic ligands
... the GSH site, and in which the aromatic moiety of S-(4-nitrophenacyl)glutathione was bound, was found buried more deeply within the dimer interface [20]. Additionally, the ligand 4- (nitrophenol) ...
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