Protein Sequence and Structure
Computational analysis of protein sequence and structure
... Chapter 5. Self-organising maps o f protein structure and sequence 158 quence information are not perfectly stable. Therefore replicate fold recognition trials should be performed with both mapped ...
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Protein sequence and structure alignments within one framework
... Combined sequence and structure alignment We have considered alignments based on class probability vectors where the original descriptors came from protein sequence (Bernoulli distributions) ...
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The MPI bioinformatics Toolkit as an integrative platform for advanced protein sequence and structure analysis.
... -strands, coiled coils, transmembrane helices and intrinsi- cally disordered regions. In parallel, the alignment could be forwarded to HHpred in order to detect distant homologs of known structure. Subsequently, ...
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PROFESS: a PROtein Function, Evolution, Structure and Sequence database
... † Present address: Thomas Triplet, Department of Computer Science, Concordia University, Montreal, Qc H3G-1M8, Canada. Submitted 2 December 2009; Revised 3 June 2010; Accepted 6 June 2010 ...
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Dissecting the relationship between protein structure and sequence evolution
... of protein are more conserved than the amino acids on the ...of sequence variability in globular ...and sequence variability can be also observed among globular ...in sequence evolution. The ...
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Sequence and Structure Signatures of Cancer Mutation Hotspots in Protein Kinases
... Abstract Protein kinases are the most common protein domains implicated in cancer, where somatically acquired mutations are known to be functionally linked to a variety of ...of protein kinase coding ...
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Protein function prediction by integrating sequence, structure and binding affinity information
... new protein sequences (265 million and counting) and experimental examinations of every protein in all its possible functional categories are simply ...combines sequence and structural information ...
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Quantifying the Relations between Protein Sequence, Structure and Function through Traditional and
... related protein sequences at various levels of similarity is an essential prerequisite for robust genome ...pairwise sequence, structure and function comparisons on 30,000 pairs of protein ...
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Comparative sequence- and structure-inspired drug design for PilF protein of Neisseria meningitidis
... assembly protein (PilF) associated with bacterial adhesion, aggregation, invasion, host cell signaling, surface motility, and natural transformation can be considered as a candidate for effective ...
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Role of Sequence and Structure of the Hendra Fusion Protein Fusion Peptide in Membrane Fusion
... of Sequence and Structure of the Hendra Fusion Protein Fusion Peptide in Membrane Fusion * Received for publication, March 30, 2012, and in revised form, June 29, 2012 Published, JBC Papers in Press, ...
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Machine Learning based Protein Sequence to (un)Structure Mapping and Interaction Prediction
... of protein function is of utmost importance in the study of protein ...well-known protein-structure function paradigm, i.e., “sequence structure function”, states that the ...
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From sequence to structure and back again: approaches for predicting protein-DNA binding
... their sequence, and relatively short (5–12 ...successful sequence-based algo- rithms are context-sensitive and account for the presence of other TFBSs [5], relative positioning to transcription start site ...
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Nodavirus Coat Protein Imposes Dodecahedral RNA Structure Independent of Nucleotide Sequence and Length
... X-ray structure of FHV has shown that 10 bp of well-ordered, double-stranded RNA are located at each of the 30 twofold axes of the virion, but it is not known which portions of the genome form these duplex ...the ...
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Improved computational methods of protein sequence alignment, model selection and tertiary structure prediction
... logarithm of e-value of the given query-template alignment, the percent of identical residue pairs in aligned positions, the percent of residues of the query that are aligned with a residue in the template, and the ...
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Robust and Efficient Algorithms for Protein 3-D Structure Alignment and Genome Sequence Comparison
... and structure analysis are two of the fundamental areas of bioinfor- matics ...specifically, protein structure related problems including protein structure alignment and query, and ...
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Protein Sequence and Structure of Organic Acid
... A protein sequence homology search demonstrated similarity between the derived amino acid sequences of both cloned genes and the derived amino acid sequence of the gene encoding filament[r] ...
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Complete Amino Acid Sequence and Structure Characterization of the Taste-modifying Protein, Miraculin*
... Amino acid sequence from the amino terminus of miraculin to the 46th amino acid residue has been determined with the whole molecule of S-carboxyamidomethylated miraculin (Fig.. As[r] ...
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A Cluster of Cuticle Protein Genes of Drosophila melanogaster at 65A: Sequence, Structure and Evolution
... We suspect also that gene conver- sion events between genes other than the duplicated Lcpa, Lcpb, and Lcpg genes have occurred at several occasions during the evolution[r] ...
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The Transmembrane Domain Sequence Affects the Structure and Function of the Newcastle Disease Virus Fusion Protein
... HN protein since the domain of the F protein that binds to the HN protein has not been clearly ...HN protein if the transmembrane domain of the NDV F protein were part of its HN ...
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Protein Evolution From Sequence To Structure.
... undergoes a transition from a random coil to an α-helix. Therefore, a complete understanding of the bHLH structure requires that unbound proteins need to be examined. The results from the homology modeling were ...
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