Structure-function relationships
The Connection of Composition, Structure, and Dynamic Processes to Tendon Mechanics: Structure-Function Relationships in Collagen V Deficient Tendons
... overall function of the ...in structure along the length of the tendon, which allow us to make generalizations about structure-function relationships that could be applicable to other ...
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Structure-Function Relationships Underlying the Replication Fidelity of Viral RNA-Dependent RNA Polymerases
... polymerase structure-function relationships and suggest that positive-strand RNA viruses retain a unique palm domain-based active-site closure mechanism to fine-tune replication ...
12
The structure/function relationships of the murine Leydig tumour (MA10) cell, luteinising hormone receptor
... Previous work in the department had established an antisense strategy which had been reported to generate truncated LH/CG receptors in MAIO cells (West and Cooke 1991b). Another o f the aims o f this project was to ...
285
Impact of chronic systolic heart failure on lung structure–function relationships in large airways
... airway structure–function ...lung function. Despite the parallel changes in EVLW and lung function there was no clear relationship between measures of air flow or lung vol- umes and EVLW ...
11
Advances in RNA Structure Prediction from Sequence: New Tools for Generating Hypotheses about Viral RNA Structure-Function Relationships
... both structure and ...energy structure may not always identify functionally relevant structures without additional experimental ...RNA structure determination is often experimentally difficult ...
9
Structure function relationships of interleukin 3 An analysis based on the function and binding characteristics of a series of interspecies chimera of gibbon and murine interleukin 3
... immunologic, and inflammatory stimuli. In addition, clinical administration of recombinant IL- 3 augments recovery in states of natural and treatment-related marrow failure. IL-3 acts by binding to high affinity cell ...
11
Structure–function relationships of A , F and V ATPases
... the cell. Moreover, A- and F-ATPases, unlike V-ATPases, share the ability to synthesize ATP. Nevertheless, lineage profiles based on primary sequence reveal that A- and V- ATPases are more closely related to each other ...
9
Structure-Function Relationships of the Mycobacterium tuberculosis Transcription Factor WhiB1
... WhiB1 structure-function relationships have shown that at least three C- terminal amino acid motifs are necessary for DNA-binding and that interaction with DNA is inhibited by the presence of a [4Fe- ...
5
Structure function relationships of ricin A chain
... stem-loop structure have been used to investigate the target site recognised by ricin and ...loop structure apparently does not contribute to identification of the target ...synthetic structure ...
464
Investigations of ion channel structure function relationships using molecular modeling and experimental biochemistry
... membranes. For example, one landmark study was the simulation of a porin, OmpF, in a phosphatidylethanolamine membrane (Tieleman and Berendsen, 1998), and this was followed in rapid succession by similar ion channel ...
14
Insight into structure: function relationships in a molecular spin-crossover crystal, from a related weakly cooperative compound
... over two orientations, labelled 'A' and 'B'. The occupancies of these two sites refined to 0.49 and 0.51, respectively, so they were each refined with half-occupancy in the final analysis. The Cl–O bonds in this anion ...
5
Monoclonal antibodies to reovirus reveal structure/function relationships between capsid proteins and genetics of susceptibility to antibody action.
... We found i close structural and functional relationships between ,ulc, a3 and crl, ii that, while serotype is defined by the crl protein, serotype-associated determinants were also prese[r] ...
10
Circumpapillary structure-function relationships with microperimetry and spectral domain optical coherence tomography in glaucoma: a pilot study
... Methods: In 14 eyes of 14 healthy subjects and 22 early–moderate POAG eyes of 22 patients, circumpapillary optical coherence tomography thickness measurements (RS-3000 Advance OCT, NIDEK) of the retinal nerve fiber layer ...
10
Assessing the structure-function relationships of the apolipoprotein(a) kringle IV sub-type 10 domain
... lysine binding ability and covalent oxPL of apo(a) KIV 10 are both implicated in vascular cell.. inflammation and atherosclerosis..[r] ...
118
Structure-function relationships of a membrane pore forming toxin revealed by reversion mutagenesis
... errors/base [22]. This error rate was further increased by using a large number of PCR cycles and a high concentration of dNTPs. PCR products were then cloned into pUC18, expressed in E. coli and colonies screened on ...
12
Structure-Function Relationships Of Rna And Protein In Synaptic Plasticity
... find structure motifs in any set of RNA ...Rfam structure families, we demonstrate that NoFold can simultaneously recapitulate almost all of the families with high sensitivity and precision and that this ...
234
Ligand Dynamics, Recognition and Structure/Function Relationships of Bio-nanoparticles.
... of structure and dynamics of the nanoparticles’ ligand layer – an essential pre-requisite for further development of Au NPs applications - is still missing in the ...dynamics, structure, and electrostatic ...
92
Structure-function relationships of HDL in diabetes and coronary heart disease
... HDL function and structure, while adjusting for potentially con- founding clinical ...unique relationships with clinical features, as well as NMR measures, proteins, and lipids of HDL ...
19
Mechanistic insights into allosteric structure function relationships at the M1 muscarinic acetylcholine receptor
... work with the ligand and/or with other residues in the complex with benzoquinazolinone 12 but not in the BQCA complex. To further understand the contribution of each of the aromatic amino acid residues to the allosteric ...
12
Regulation and structure/function relationships of the Rac1 GTPase-activating protein, n-chimaerin
... Although GAPs are involved in the downregulation o f p21s, GAPs may themselves be effectors. Suggestions that GAPs may have effector functions have been obtained from studies on p i 20-GAP. These studies indicate that: ...
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