The Latency Associated Transcripts
Evidence that two latency-associated transcripts of herpes simplex virus type 1 are nonlinear.
... The latency-associated transcripts (LATs) of herpes simplex virus type 1 (HSV-1) are the only viral gene products that accumulate to abundant levels in latently infected ...
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Marek's disease virus latency-associated transcripts belong to a family of spliced RNAs that are antisense to the ICP4 homolog gene.
... (MDV) latency-associated transcripts include at least two MDV small RNAs (MSRs) and a 10-kb RNA which map antisense to the ICP4 homolog gene and are relatively abundant in MDV- transformed ...
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Analysis of the promoter and cis-acting elements regulating expression of herpes simplex virus type 2 latency-associated transcripts.
... and Research, Food and Drug Administration, Bethesda, Maryland 20892 Received 11 November 1994/Accepted 9 February 1995 In latently infected neurons, herpes simplex virus type 2 (HSV-2) expresses one abundant family of ...
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Quantitation of herpes simplex virus type 1 DNA and latency-associated transcripts in rabbit trigeminal ganglia demonstrates a stable reservoir of viral nucleic acids during latency.
... In this investigation we determined the dynamics of herpes simplex virus type 1 (HSV-1) DNA and latency- associated transcripts (LAT) in the latently infected rabbit trigeminal ganglion. Rabbit eyes ...
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Investigation of DNA Sequences Related to Latency Associated Transcripts in the Genome of Canine Herpesvirus Type 1 (CHV 1) by Means of Bioinformatics Tools
... cy-Associated Transcripts of Equid Herpesvirus 1 in Equine Leukocytes But Not in Trigeminal ...pesvirus-1 Latency-Associated Transcripts in the Trigeminal Ganglia and Corneas of Cats ...
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Identification of cis-acting sequences in the promoter of the herpes simplex virus type 1 latency-associated transcripts required for activation by nerve growth factor and sodium butyrate in PC12 cells.
... the latency-associated transcripts (LATs) is likely regulated by cellular factors during latent infection of neurons with herpes simplex virus type ...during latency, we have at- tempted to ...
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Identification of Human Herpesvirus 6 Latency-Associated Transcripts
... Productive-phase transcripts are also ...scale. Latency-associated exons starting from LSS1 and LSS2 are ...latent transcripts were located approximately ...putative latency- ...
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Influence of Herpes Simplex Virus 1 Latency-Associated Transcripts on the Establishment and Maintenance of Latency in the ROSA26R Reporter Mouse Model
... during latency, we consistently observed reductions in marked-cell populations dur- ing LAT-negative virus but not LAT-positive ...of latency among distinct neuronal subpopulations is equivalent to that ...
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Detection of latency-associated transcripts of equid herpesvirus 1 in equine leukocytes but not in trigeminal ganglia.
... EHV-1 transcripts could not be detected in 30 TG sections (approximately 5.5 3 10 3 neurons). DISCUSSION In this paper we have presented three lines of evidence for the occurrence of LATs in equine lymphoid ...
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Relationship between polyadenylated and nonpolyadenylated herpes simplex virus type 1 latency-associated transcripts.
... RNA was isolated from lytically infected rabbit skin cells or latently infected murine sensory nerve ganglia, fractionated into poly(A)+ and poly(A)- fractions, size fractionated, blotte[r] ...
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Identification of latency-associated transcripts that map antisense to the ICP4 homolog gene of Marek's disease virus.
... Two small RNAs (0.9 and 0.75 kb), named Marek's disease virus (MDV) small RNAs (MSRs) and a 10-kb RNA, all of which map antisense to the MDV ICP4 homolog gene, have been readily detected[r] ...
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Structural and kinetic analyses of herpes simplex virus type 1 latency associated transcripts in human trigeminal ganglia and in cell culture
... transcripts (LATs). The LATs appear to modulate virus reactivation. In mice and rabbits the 5' origins, kinetics of synthesis, and splicing pattern of the LATs are well established. Because these details of LAT ...
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Expression of herpes simplex virus type 1 (HSV-1) latency-associated transcripts and transcripts affected by the deletion in avirulent mutant HFEM: evidence for a new class of HSV-1 genes.
... During latent herpes simplex virus type 1 (HSV-1) infection in the trigeminal ganglia of mice, three virus-specific transcripts, 2.0, 1.5, and 1.45 kilobases (kb), are detectable by Nort[r] ...
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Expression of herpes simplex virus type 1 latency-associated transcripts in the trigeminal ganglia of mice during acute infection and reactivation of latent infection.
... During the reactivation of latent HSV-1 from explanted trigeminal ganglia, the latency-associated RNAs decreased about twofold, but were present at significant levels even after HSV-1 DN[r] ...
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Herpes Simplex Virus Type 1 Latency-Associated Transcripts Suppress Viral Replication and Reduce Immediate-Early Gene mRNA Levels in a Neuronal Cell Line
... viral latency, we constructed stably transfected neuronal cell lines containing (i) the entire HSV-1 latency transcriptionally active DNA fragment, (ii) the same DNA sequence with deletions of the ...HSV-1 ...
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The abundant latency-associated transcripts of herpes simplex virus type 1 are bound to polyribosomes in cultured neuronal cells and during latent infection in mouse trigeminal ganglia.
... Spivack in reference 46), and tagging of the five large ORFs of the mLAT was intended to reveal whether they are expressed during HSV-1 latency. However, this region contains 16 ORFs that are longer than 50 codons ...
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A Virus with a Mutation in the ICP4-Binding Site in the L/ST Promoter of Herpes Simplex Virus Type 1, but Not a Virus with a Mutation in Open Reading Frame P, Exhibits Cell-Type-Specific Expression of γ134.5 Transcripts and Latency-Associated Transcripts
... ICP4 transcripts in both neu- ral (NB41A3) and nonneural (Vero) cells, these immediate- early transcripts were expressed at markedly reduced levels in NB41A3 cells relative to Vero cells infected with all ...
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Herpes Simplex Virus Type 2 (HSV-2) Establishes Latent Infection in a Different Population of Ganglionic Neurons than HSV-1: Role of Latency-Associated Transcripts
... HSV latency, 25% of HSV-1 latency-associated transcript (LAT)- and 4% of HSV-2 LAT-expressing neurons were A5 positive, while 12% of HSV-1 LAT- and 42% of HSV-2 LAT-expressing neurons were KH10 ...of ...
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Herpes Simplex Virus Type 1 Latently Infected Neurons Differentially Express Latency-Associated and ICP0 Transcripts
... the latency-associated transcripts (LATs) are the most abundant viral transcripts present in neurons, but some immediate-early viral tran- scripts, such as those encoding ICP0, have also been ...
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Accumulation of Viral Transcripts and DNA during Establishment of Latency by Herpes Simplex Virus
... resembles latency. To assess events during establishment of latency by wild-type and thymidine kinase-negative viruses, we quantified specific viral nucleic acid sequences in mouse trigeminal ganglia during ...
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