[PDF] Top 20 Herpes simplex virus type 1 latency-associated transcript (LAT) promoter deletion mutants can express a 2-kilobase transcript mapping to the LAT region.
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Herpes simplex virus type 1 latency-associated transcript (LAT) promoter deletion mutants can express a 2-kilobase transcript mapping to the LAT region.
... The data for KOS/29 LAT-related RNA expression suggest the presence of a second promoter in the LAT gene which can function in tissue culture infection, at low levels in acute infection [r] ... See full document
8
The 2.2-Kilobase Latency-Associated Transcript of Herpes Simplex Virus Type 2 Does Not Modulate Viral Replication, Reactivation, or Establishment of Latency in Transgenic Mice
... (Fig. 1), included a 5,277-bp genomic DNA fragment of HSV-2 strain 333 consisting of the sequences 1,167 bp upstream and 4,114 bp downstream of the LAT transcription initiation site ...the LAT ... See full document
7
The 2-Kilobase Intron of the Herpes Simplex Virus Type 1 Latency-Associated Transcript Has a Half-Life of Approximately 24 Hours in SY5Y and COS-1 Cells
... the 2-kb LAT ...cell type specific in some cases (5, 6, ...of LAT between human neuron-like SY5Y cells and monkey COS-1 ...they express the dopamine--hydroxy- lase ... See full document
9
Analysis of the 2-kilobase latency-associated transcript expressed in PC12 cells productively infected with herpes simplex virus type 1: evidence for a stable, nonlinear structure.
... with herpes simplex virus type 1 (HSV-1), the only transcripts detected by Northern blot or in situ hybridization are the latency-associated transcripts (LATs) (9, ... See full document
5
Herpes Simplex Virus 2 Latency-Associated Transcript (LAT) Region Mutations Do Not Identify a Role for LAT-Associated MicroRNAs in Viral Reactivation in Guinea Pig Genital Models
... that herpes simplex virus (HSV) latency-associated transcript (LAT) promoter deletion viruses show impaired recur- rence phenotypes in relevant animal ... See full document
12
In vivo deletion analysis of the herpes simplex virus type 1 latency-associated transcript promoter.
... recombinant virus KOS/1 has been described previously ...The promoter consists of a SmaI-to-SacII DNA restriction fragment which extends to bp 2863 relative to the LAT transcription start ... See full document
7
Herpes Simplex Virus Latency-Associated Transcript Sequence Downstream of the Promoter Influences Type-Specific Reactivation and Viral Neurotropism
... During latency, HSV-1 and HSV2-LAT-S1 did not re- activate ...lasting 1 to 2 days, similar in character to recurrences produced by HSV-2, HSV2-LAT-P1, and ...HSV-1 ... See full document
9
Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene Promotes Neuronal Survival
... the region of the ...the region that was deleted in the LAT null ...1.9-kb deletion in the LAT null mutants should not adversely affect the expression of any known HSV-1 ... See full document
16
A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation.
... Latency-associated transcript (LAT) promoter deletion mutants of herpes simplex virus type 1 have a reduced capacity to reactivate ... See full document
11
The Latency-Associated Transcript Gene Enhances Establishment of Herpes Simplex Virus Type 1 Latency in Rabbits
... viral mutants. The parental virus for ⌬LAT-EGFP was dLAT2903, a mutant of HSV-1 strain McKrae containing a ...HpaI) deletion in both copies of LAT that removed 0.2 kb of the ... See full document
7
Deacetylation of the Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Enhancer and a Decrease in LAT Abundance Precede an Increase in ICP0 Transcriptional Permissiveness at Early Times Postexplant
... Herpes simplex virus type 1 (HSV-1) is characterized by its ability to establish latency as an episome in neurons ...the latency-associated transcript ... See full document
6
A Novel Herpes Simplex Virus Type 1 Transcript (AL-RNA) Antisense to the 5′ End of the Latency-Associated Transcript Produces a Protein in Infected Rabbits
... infection, herpes simplex virus type 1 (HSV-1) establishes a lifelong latent infection in sensory neurons of the trigeminal ...ganglia. Latency-associated ... See full document
8
A 371-nucleotide region between the herpes simplex virus type 1 (HSV-1) LAT promoter and the 2-kilobase LAT is not essential for efficient spontaneous reactivation of latent HSV-1.
... parental virus because its high spontaneous-reactivation rate in rabbits allows changes in the spontaneous-reactivation rates of mu- tants to be detected and analyzed statistically (16, ...of LAT ... See full document
5
A Herpes Simplex Virus Type 1 Latency-Associated Transcript Mutant with Increased Virulence and Reduced Spontaneous Reactivation
... the virus, ...of LAT as described in Materials and ...StyI-StyI deletion in the 1.5-kb LAT insert in the unique long region of ...The deletion in both original copies of ... See full document
10
The Stable 2-Kilobase Latency-Associated Transcript of Herpes Simplex Virus Type 1 Can Alter the Assembly of the 60S Ribosomal Subunit and Is Exported from Nucleus to Cytoplasm by a CRM1-Dependent Pathway
... the 2-kb LAT intron, aside from the expected LAT ...intron deletion mutants revealed a dis- tribution of the 28S rRNA similar to that found in mock- ...FIG. 2. The 2-kb ... See full document
7
The Stable 2.0-Kilobase Intron of the Herpes Simplex Virus Type 1 Latency-Associated Transcript Does Not Function as an Antisense Repressor of ICP0 in Nonneuronal Cells
... 2.0-kb LAT intron from the cis-acting properties of the LAT ...2.0-kb LAT intron at various levels, similar to those found during lytic ...encoded LAT on ICP0 expression in these cells were ... See full document
15
Two open reading frames (ORF1 and ORF2) within the 2.0-kilobase latency-associated transcript of herpes simplex virus type 1 are not essential for reactivation from latency.
... None of the variants reported thus far contain a deletion that starts precisely at the 5' end of the 2.0-kb LAT or a deletion and/or insertion disrupting the putative ORF2 of 8071 Downlo[r] ... See full document
11
In Vivo Knockdown of the Herpes Simplex Virus 1 Latency-Associated Transcript Reduces Reactivation from Latency
... LAT promoter mutants exhibit a reduction in genome copy numbers 2- to 3-fold within sensory ganglia compared to wild-type HSV, presumably due to the LAT’s ability to protect neurons ... See full document
10
In vivo epinephrine reactivation of ocular herpes simplex virus type 1 in the rabbit is correlated to a 370-base-pair region located between the promoter and the 5' end of the 2.0 kilobase latency-associated transcript.
... FIG. 2. Southern blot analysis of DNA isolated from virus following in vivo reactivation or explant ...rescuant virus were explanted. The DNA from reactivated virus was isolated, digested with ... See full document
5
Three Herpes Simplex Virus Type 1 Latency-Associated Transcript Mutants with Distinct and Asymmetric Effects on Virulence in Mice Compared with Rabbits
... The LAT gene is located in the viral long repeats and is thus present in two ...8.3-kb LAT transcript is shown expanded below the genome. The stable 2-kb LAT is indicated by a black ... See full document
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