[PDF] Top 20 Cassette mutagenesis of the reverse transcriptase of human immunodeficiency virus type 1.
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Cassette mutagenesis of the reverse transcriptase of human immunodeficiency virus type 1.
... Mutational analysis of the DNA polymerase and ribonuclease H activities of human immunodeficiency virus type 2 reverse transcriptase expressed in Escherichia coli.. Reconstitution in vit[r] ... See full document
9
Attenuated replication of human immunodeficiency virus type 1 with a didanosine-selected reverse transcriptase mutation.
... in human immunodeficiency virus type 1 reverse transcriptase (RT) develops as a consequence of didanosine (ddI) therapy and is associated with a decreased susceptibility ... See full document
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Influence of Reverse Transcriptase Variants, Drugs, and Vpr on Human Immunodeficiency Virus Type 1 Mutant Frequencies
... of human immunodeficiency virus type 1 (HIV-1) ...HIV-1 reverse transcriptase (RT) is a major target of antiretroviral therapy and ultimately the target of ... See full document
10
The M184V Mutation in the Reverse Transcriptase of Human Immunodeficiency Virus Type 1 Impairs Rescue of Chain-Terminated DNA Synthesis
... of human immunodeficiency virus type 1 (HIV-1) resistant to antiviral drugs is a major ...the virus-en- coded reverse transcriptase (RT) and protease enzymes ... See full document
7
Construction and Characterization of a Temperature-Sensitive Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutant
... (ts) human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) mutant was generated by charged-cluster-to-alanine ...mutant virus, containing ... See full document
8
Amino Acid Mutation N348I in the Connection Subdomain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confers Multiclass Resistance to Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors
... of human immunodeficiency virus type 1 (HIV-1) infections in highly active antiretroviral therapies (HAART) can dramati- cally reduce viral load, increase levels of CD4positive ... See full document
10
Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors.
... 4887 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Human immunodeficiency virus type 1 HIV-1-specific pyridinone reverse transcriptase RT inhibitors prevent HIV-1 rep[r] ... See full document
6
Human Immunodeficiency Virus Type 1 Subtype F Reverse Transcriptase Sequence and Drug Susceptibility
... Most human immunodeficiency virus type 1 (HIV-1) drug susceptibility studies have involved subtype ...nonnucleoside reverse transcriptase (RT) inhibitors (8), as is ... See full document
5
Mutations in the Thumb Allow Human Immunodeficiency Virus Type 1 Reverse Transcriptase To Be Cleaved by Protease in Virions
... Although human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) has been extensively studied, there are still significant questions about the ... See full document
9
Hypersusceptibility to Substrate Analogs Conferred by Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase
... Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) contains four structural motifs (A, B, C, and D) that are conserved in polymerases from ... See full document
10
Effects of Human Immunodeficiency Virus Type 1 Resistance to Protease Inhibitors on Reverse Transcriptase Processing, Activity, and Drug Sensitivity
... Human immunodeficiency virus type 1 (HIV-1) variants resistant to protease inhibitors often display a reduced replicative capacity as a result of an impairment of protease ...of ... See full document
5
HuR interacts with human immunodeficiency virus type 1 reverse transcriptase, and modulates reverse transcription in infected cells
... of human immunodeficiency virus type 1 (HIV-1) is a critical step in the replication cycle of this ...by reverse transcriptase (RT), is well characterized at the ... See full document
14
Sequence and drug susceptibility of subtype C reverse transcriptase from human immunodeficiency virus type 1 seroconverters in Zimbabwe.
... occurring human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) variability has implications for the success of antiretroviral ...from virus ... See full document
8
Effect of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Polymorphism Leu-214 on Replication Capacity and Drug Susceptibility
... Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) is responsible for the conversion of the viral single-stranded RNA genome into ... See full document
6
Clinical data sets of human immunodeficiency virus type 1 reverse transcriptase-resistant mutants explained by a mathematical model.
... of human immunodeficiency virus type 1 (HIV-1) infection during the clinical latency phase with drugs inhibiting reverse transcriptase (RT) reduces the HIV-1 ... See full document
8
Mutations That Abrogate Human Immunodeficiency Virus Type 1 Reverse Transcriptase Dimerization Affect Maturation of the Reverse Transcriptase Heterodimer
... abrogate human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) dimerization on virus replication is not known, as mutations shown previously ... See full document
11
Differentiation between human immunodeficiency virus type 1 (HIV 1) and HIV 2 isolates by nonradioisotopic reverse transcriptase typing assay
... We tested whether human immunodeficiency virus type 1 HIV-1 could be differentiated from HIV-2 by a reverse transcriptase RT-typing assay that measured the reduction of enzyme activity o[r] ... See full document
6
Involvement of Novel Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutations in the Regulation of Resistance to Nucleoside Inhibitors
... in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) whose role in drug resistance is still unknown by analyzing 1,906 plasma-derived ... See full document
13
Comparison of Sequencing by Hybridization and Cycle Sequencing for Genotyping of Human Immunodeficiency Virus Type 1 Reverse Transcriptase
... in human immunodeficiency virus type 1 reverse transcriptase (RT) in viruses isolated from highly RT inhibitor-experienced ... See full document
7
Effects of Amino Acid Substitutions at Position 115 on the Fidelity of Human Immunodeficiency Virus Type 1 Reverse Transcriptase
... serum albumin per ml, 10 mM CHAPS {3-[(3-cholamidopropyl)-dimethylam- monio]-1-propanesulfonate}, and 20 M each dATP, dCTP, dGTP, and dTTP. One microgram of either wild-type HIV-1 RT or the Y115F ... See full document
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