[PDF] Top 20 Comparative effects of A.T and G.C sequence selective DNA minor groove binding agents
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Comparative effects of A.T and G.C sequence selective DNA minor groove binding agents
... the DNA binding characteristics of the synthetic lexitropsins ARI 114 and ARI 144 in chapter 3 showed that the compounds have distinctive, but not overlapping DNA recognition patterns (This is also ... See full document
227
Interaction of DNA with groove binding ligands
... both DNA and RNA ...narrower groove of both DNA and RNA and appear more sequence dependent in the case of ...and minor groove sites and are strongly coupled to DNA bending ... See full document
235
Positive Impact Program Evaluation
... Minor groove DNA binding compounds hold great potential for new drugs, not only as anti-parasitics, but also as human genome regulators that can target other ...Although ... See full document
114
Molecular pharmacology of a series of nitrogen mustard containing-and AT- and GC- recognising minor groove binding agents related to distamycin
... o t perfect, m echloretham ine an d m elp h ala n reacted p refe ren tially w ith the m o st electro n eg ativ e g u an in es, w hile the m eth y latin g ag en t DMS sh o w ed little ... See full document
230
Protein and drug interactions in the minor groove of DNA
... of DNA, its minor ...non-covalent binding agents (1–3) and, in particular, for designed polyamide-based sequence-specific molecules ...the minor groove (5,6) and ... See full document
10
Constructing Empirical Likelihood Confidence Intervals for Medical Cost Data with Censored Observations
... of minor groove binding compounds, have been shown to inhibit interactions of transcription factors binding to genomic ...understand sequence specific recognition of DNA better ... See full document
218
Rationalising sequence selection by ligand assemblies in the DNA minor groove : the case for thiazotropsin A
... decamer DNA constructs used in ITC and NMR studies, respectively, present different peripheral DNA sequences (top) to the ligand compared with those of the two possible 15-mer binding sites (middle ... See full document
12
The antibacterial drug MGB-BP3 : from discovery to clinical trial
... and selective, high antibiotic activity ...the minor groove of DNA and details of the configuration of binding were known from X-ray crystallography ...new minor groove ... See full document
9
Entropic binding mode preference in cooperative homo-dimeric drug-DNA recognition
... the DNA double-helix structure in 1953 by Watson and ...side effects associated with DNA binding drugs, at least in part, are directly linked to their relatively weak DNA ... See full document
9
2D-IR spectroscopy shows that optimised DNA minor groove binding of Hoechst33258 follows an induced fit model
... in binding to proteins, but rarely invoked in small-molecule-DNA ...the sequence selectivity of ligand binding to the minor groove of target dsDNA ...the binding of H33258 ... See full document
24
Thiazotropsin aggregation and its relationship to molecular recognition in the DNA minor groove
... the DNA minor groove and classical small molecule DNA binders including Hoechst 33258 [1-234567] berenil [8,9] netropsin [10] distamycin A [11,12] and their derivatives ( ...peptide ... See full document
37
Microarray and Genome-wide Sequencing Approaches to Characterizing DNA Binding Molecules
... The sequence logo for polyamide 4 indicates that Im has modest preference for G·C or A·T over other base pairings—in this mutational study, however, imidazole is generally ...in binding affi nities is the ... See full document
223
Minor groove binders: some recent research in drug development
... of DNA on gene expression ...of minor groove DNA binding agents with the potential to “bend ...these agents consisted of connecting the sequence recognition ... See full document
11
Triplex Forming Oligonucleotides – Tool for Gene Targeting
... by binding to the minor groove of DNA in a sequence-specific manner, and usually refer to polymers containing N-methylimida- zole and N-methylpyrrole amino ...the minor ... See full document
6
Dinuclear polypyridyl ruthenium(II) complexes as stereoselective probes of nucleic acid secondary structures
... base sequence. Such a sequence might belong to a specific gene or its promoter or enhancer regions, with the subsequent binding resulting in some degree of modulation of the gene ...Selectively ... See full document
171
Towards a new methodology for the determination of sequence selectivity in small molecule-DNA binding
... the minor groove (although several van der Waals contacts were still ...alternative binding site in solution for the hexamer ...major groove to the hydroxyls still exist, but the lack of the ... See full document
254
Ranking ligand affinity for the DNA minor groove by experiment and simulation
... of minor-groove binders (MGBs) with DNA is not fully ...using DNA footprinting, nuclear magnetic resonance spectroscopy, isothermal titration calorimetry and molecular dynamics, we have ... See full document
13
Sequence-selective minor groove recognition of a DNA duplex containing synthetic genetic components
... While our MD calculations show that DNA7 adopts an overall B-type duplex (Figure 4a,b), there is a change in the shearing, stretching, and propeller twist at the site of the P · Z pair in DNA7 relative to the cognate ... See full document
9
Minor groove binders for DNA as antitypanosomal agents : the veterinary context
... diamidine minor groove binding trypanocidal drugs cause destruction of the kinetoplast, which is an essential component of their mechanism of ... See full document
19
Impact of pyrrolidine-bispyrrole DNA minor groove binding agents and chirality on global proteomic profile in Escherichia Coli
... and DNA protection during starvation ...Interestingly, selective proteins were differentially expressed in response to either PySSPy or PyRSPy ...subunit C and KHG/KDPG ... See full document
9
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