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Deleterious background selection with recombination.
... for distinguishing between the background selection and the hitchhiking models. Many properties of genetic variation depend on the effective population size. The analysis th[r] ... See full document
13
The Evolution of Selfing Is Accompanied by Reduced Efficacy of Selection and Purging of Deleterious Mutations
... of selection in selfing populations will also be affected by how strongly recessive mutations are masked by ...their deleterious effects has been hy- pothesized (Simmons and Crow 1977; Crow and Simmons ... See full document
40
The evolution of recombination rates caused by recurrent deleterious mutations
... female deleterious mutation rate is lower than the male mutation rate may be unrealistic if the number of insertions and deletions is ...stronger selection than point mutations since they often disrupt open ... See full document
120
Effects of Recombination Rate on Human Endogenous Retrovirus Fixation and Persistence
... the deleterious gene product model (36), a solo-LTR does not express retroviral genes or form new viral particles that could be ...negative selection would act quickly against intact and active viruses, ... See full document
6
Selection Intensity Against Deleterious Mutations in RNA Secondary Structures and Rate of Compensatory Nucleotide Substitutions
... be deleterious but neutral in appropriate ...that selection increases the substitution time dramatically when selection intensity Ns ⬎ 1, where N is the diploid population size and s the ... See full document
11
Distinguishing the Hitchhiking and Background Selection Models
... Other interesting species to study are partially selfing plants, in which recombination is “effectively” reduced in the whole genome. We use two tomato species, Lyco- persicon pimpinellifolium and L. chmielewskii, ... See full document
6
Genomic Background and Generation Time Influence Deleterious Mutation Rates in Daphnia
... how selection shapes mutation rates over evolutionary time requires knowledge of the factors influencing mutation and its effects on quantitative ...genomic background and generation time, on ... See full document
22
Effect of Recombination on the Accuracy of the Likelihood Method for Detecting Positive Selection at Amino Acid Sites
... While recombination is erate purifying selection (Golding 1997; Przeworski an evolutionary force maintaining genetic diversity, in et ...by background selection (Charlesworth et ...positive ... See full document
8
Selection for Recombination in Structured Populations
... 1932)], deleterious mutations [as in Muller’s ratchet (M uller 1932)], or both (P eck ...and recombination to reduce negative associations among the most fit alleles generated by drift in the pres- ence of ... See full document
17
Weakly Deleterious Mutations and Low Rates of Recombination Limit the Impact of Natural Selection on Bacterial Genomes
... Background selection should drastically reduce the effective population size of ...of background selection, or the linkage between many alleles (24, ...slightly deleterious mutations ... See full document
10
Background Selection in Partially Selfing Populations
... the deleterious allele and the recombination rate are replaced by the effective pa- rameters hð1 2 FÞ þ F and rð1 2 FÞ: Similarly, Agrawal and Hartfield (2016) showed that in a population reproducing ... See full document
25
Joint Effects of Genetic Hitchhiking and Background Selection on Neutral Variation
... selected deleterious mutations, directional selection on favorable alleles (causing hitchhiking effects on linked neutral polymorphisms) is expected to occur while a deleteri- ous mutation-selection ... See full document
13
The effect of deleterious mutations on neutral molecular variation.
... Approximate formulas are derived for the reduction below classical neutral values resulting from such background selection against deleterious mutations, for the mean times [r] ... See full document
15
An Adaptive Hypothesis for the Evolution of the Y Chromosome
... that selection favors an increase in the expression of (fit) X-linked alleles and a decrease in the expression of (unfit) Y-linked ...of deleterious alleles on the Y by background ... See full document
6
Divergence of the yellow Gene Between Drosophila melanogaster and D. subobscura: Recombination Rate, Codon Bias and Synonymous Substitutions
... This pattern of divergence is consistent with the hitchhiking and background selection models that predict an increase in the fixation rate of slightly deleterious mutatio[r] ... See full document
11
Joint Prediction of the Effective Population Size and the Rate of Fixation of Deleterious Mutations
... that recombination hotspots account for around 70% of recombination events (average numbers taken from Myers et ...by selection, deleterious mutation rates for humans have been estimated to be ... See full document
28
Fixation of a deleterious allele under mutation pressure and finite selection intensity.
... In this work we have considered a model motivated by the problem of fixation in systems experiencing amorphic or hypermorphic mutations, and studied the dynamics of a panmictic diallelic population of diploid individuals ... See full document
27
Evidence for Abundant Slightly Deleterious Polymorphisms in Bacterial Populations
... synonymous polymorphisms in the process of being eliminated by purifying selection, as predicted to occur in populations with large effective size by the nearly neutral theory. The major exceptions to this trend ... See full document
6
The coalescent process in models with selection and recombination.
... The statistical properties of the process describing the genealogical history of a random sample of genes at a selectively neutral locus which is linked to a locus at w[r] ... See full document
10
SELECTION ON RECOMBINATION IN A MULTI-LOCUS SYSTEM
... WILLS and MILLER (1976) proposed “a model for outbreeding populations in which there can be selection for relatively free recombination,” which they claim “does not rely on [r] ... See full document
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