[PDF] Top 20 Effect of interferon on replication of herpes simplex virus types 1 and 2 in human macrophages.

... 1 0022-538X/86/100037-06$02.00/0 Copyright © 1986, American Society for Microbiology Effect of Interferon Replication of Herpes Simplex Virus Types and 2 in Human Macrophages on 1 INGRID[r] ... See full document

... In order to determine the in vivo effect of IFNs on HSV-1 replication, three different cell lines, HEp-2 human epithelial fibroblasts, Vero African green monkey kidney, and WISH human am[r] ... See full document

... the human IFN-␤ transgene express pSTAT1 levels 24 h ...the human IFN-␣2 trans- gene is absent, similar to expression in nontransfected, infected cells, suggesting that IFN-␤ may counter the action ... See full document

... ␤ 1 or IFN- ␥ ...␤ 1 and signifi- cantly down-regulated by HSV-1 infection ...little effect in reversing the induction of these genes in cells pretreated with IFN- ␤ 1 and/or IFN- ␥ for ... See full document

... Herpes simplex virus 1 (HSV-1) is a common pathogen infecting the majority of people worldwide at some stage in their ...including macrophages. Here, we have characterized the ... See full document

... its effect on DCs, GM-CSF also has been reported to be an M1 stimulus ...M2 macrophages, may be more effective in reducing HSV-1 latency than IFN- ␥ treatment, at least in ...the macrophages ... See full document

... this effect in transfected cells, sug- gesting that other viral proteins may be involved ...among human herpesviruses and will clarify the potential role of UL12 orthologs in this process for viruses other ... See full document

... the human monocyte U937 cell line (ATCC ® Number ...the virus was grown and titrated by plaque assay on African green monkey kidney cells (Vero), as previously described ...of 1 and 10 plaque forming ... See full document

... 1354 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The replication of herpes simplex virus type 1 HSV-1 is not inhibited in either HeLa or HEp-2 cells treated with hu[r] ... See full document

... AAV2 multiplication was similarly efficient in HSV-1 coinfections of HeLa cells, whereas lower yields were obtained in HEp-2 and primary human embryonic kidney cells.. HSV-1 also support[r] ... See full document

... erpes simplex virus type-1 (HSV-1) is widely distributed in the human population and is the leading cause of acute sporadic viral encephalitis and viral induced blindness [1, ... See full document

... the human monocyte cell line U937, which lacks SAMHD1 expression ...FIG 1 Replication of HSV-1 is enhanced in SAMHD1-depleted ...progeny virus titers using plaque assays in Vero ... See full document

... that interferon was not produced during infection of HFL cells with wild-type HSV-1 or with mutants blocked such that IE gene products were not ex- pressed, based on the finding that medium from cells ... See full document

... gamma interferon (IFN- ␥ ) can directly inhibit the replication of herpes simplex virus type 1 ...HSV-1 replication in ...HSV-1 replication in vitro ... See full document

... Induced reactivation was also apparent in assays of gangli- onic sections for HSV-1 antigen by immunoperoxidase stain- ing. Two to four mice in each group (GKO, RGKO, and control 129/Sv//Ev mice) were euthanatized ... See full document

... robust replication in tumor cells, suggests that ΔN146 is a unique oncolytic ...EUs11 virus, which mediates an immunosuppressive ...synthase, interferon-inducible protein 16, and DEAD box helicase ... See full document

... a replication-competent controlled HSV may have significant ad- vantages over a vector such as ...controlled virus relies on spatiotemporal regulation rather than attenuation, such a virus could be ... See full document

... Of a series of temperature-sensitive mutants of HSV-2 strain HG52, ts9 and tsl3 failed to induce wild-type levels of the enzyme at nonpermissive temperature; ts9 was the most defective m[r] ... See full document

... The presence of HSV nucleocapsids in IFN-treated neuroblastoma cells and the expression of nucleocapsid proteins, including VP5, indicate that in this system, IFN blocks virus replicatio[r] ... See full document

... A Lane 1, modified gD-1 mock digested with trypsin and immunoprecipitated with anti-gD-1 serum; lane 2, modified gD-1 mock digested with trypsin and immunoprecipitated with group VII 170[r] ... See full document