[PDF] Top 20 Effects of alterations of primer-binding site sequences on human immunodeficiency virus type 1 replication.
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Effects of alterations of primer-binding site sequences on human immunodeficiency virus type 1 replication.
... During early stages of infection, the two PBS mutants, in conjunction with tRNA1Ls and tRNAPhe, appar- An early, critical step in the human immunodeficiency virus type HIV-1 life cycle i[r] ... See full document
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Nucleotide substitutions within U5 are critical for efficient reverse transcription of human immunodeficiency virus type 1 with a primer binding site complementary to tRNA(His).
... in replication between viruses derived from pHXB2(His-AC-TGT) and pHXB2(His- AC-GAC) was magnified when they contained the M184V RT ...in replication could have been due to defects in one or multiple steps ... See full document
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Human immunodeficiency virus type 1 can use different tRNAs as primers for reverse transcription but selectively maintains a primer binding site complementary to tRNA(3Lys).
... RNA primer that remains following incomplete digestion by the viral RNase H activity at the polypurine tract located just upstream of the U3 region in the viral ...still-attached primer tRNA used to ... See full document
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Antigenic Variation within the CD4 Binding Site of Human Immunodeficiency Virus Type 1 gp120: Effects on Chemokine Receptor Utilization
... negligible binding to sCD4-Ig were cloned from both proviral DNA and viral RNA sources, suggesting that these variants were not derived from a latent proviral ...from replication- competent viruses and to ... See full document
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Identification of sequences downstream of the primer binding site that are important for efficient replication of human immunodeficiency virus type 1.
... (nt) primer binding site (PBS), located within the 5 * region of viral genomic RNA, to which the host cell-derived tRNA primer is annealed and also involves viral genomic sequences ... See full document
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Redundant Roles for Nucleocapsid and Matrix RNA-Binding Sequences in Human Immunodeficiency Virus Type 1 Assembly
... to binding of RNA by multiple Gags, which in turn organizes and stabilizes the Gag-Gag interactions that form the ...the human immunodeficiency virus type 1 (HIV-1) Gag ... See full document
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Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication.
... transfer in vitro (7, 43, 52), whereas the core domain is suffi- cient for disintegration activity (4, 32). The core domain is composed of two subdomains; one part, originally identified as a relatively protease ... See full document
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The hydrophobic pocket of cyclophilin is the binding site for the human immunodeficiency virus type 1 Gag polyprotein.
... observed binding properties may be due to the fact that CyPB possesses a 33-amino-acid hydrophobic leader peptide not found in CyPA (19); it is pos- sible that the in vitro binding properties of CyPB are ... See full document
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Identification of the Optimal DC-SIGN Binding Site on Human Immunodeficiency Virus Type 1 gp120
... 2G12 binding to gp120, but 2G12 does not inhibit ConA and CVN binding to gp120 (25, ...high-mannose binding lectins. While both ConA and CVN can bind to Man- ␣ -(1-2)-Man- ␣ moieties, they ... See full document
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Identification of an APOBEC3G Binding Site in Human Immunodeficiency Virus Type 1 Vif and Inhibitors of Vif-APOBEC3G Binding
... following binding of APOBEC3G to GST-Vif, whereas the signal obtained with GST-Vif(90–140) was similar to that of the GST control ...Vif-APOBEC3G binding by approximately 80% ...Vif-APOBEC3G binding ... See full document
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Identification of a sequence within U5 required for human immunodeficiency virus type 1 to stably maintain a primer binding site complementary to tRNA(Met).
... of virus from COS-1 cells transfected with the wild-type and mutant proviral ...released virus particles by quantitation of p24 antigen by ELISA ...infectious virus derived from ... See full document
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Human Immunodeficiency Virus Type 1 Infection and Replication in Normal Human Oral Keratinocytes
... (48). Binding studies have shown that the recognition site for GalCer is located in the V3 loop of gp120 (47), although the C2 domain (amino acids 266 to 275) may also be involved ...normal human ... See full document
7
Cyclophilin A-induced alterations of human immunodeficiency virus type 1 CA protein in vitro.
... antigenic site recognized by the anti-CyP A antibody was masked by interaction with ...CA sequences in the Gag precursor that occurs during incorporation of CyP A into the ... See full document
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The Human Immunodeficiency Virus Type 1 Gag Polyprotein Has Nucleic Acid Chaperone Activity: Possible Role in Dimerization of Genomic RNA and Placement of tRNA on the Primer Binding Site
... What is the biological significance of the nucleic acid chap- erone activity of Gag? Analysis of protease-deficient, imma- ture virions, in which the Gag polyprotein is not cleaved, shows that they contain dimers of ... See full document
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Differential Effects on Human Immunodeficiency Virus Type 1 Replication by α-Defensins with Comparable Bactericidal Activities
... The mechanism of enhanced HIV entry mediated by Crp3 is not known. Possibly, at nonlytic concentrations, the cationic Crp3 molecule may be juxtaposed between electronegative viral and cell membrane phospholipids and thus ... See full document
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Role of the DIS hairpin in replication of human immunodeficiency virus type 1.
... of human immunodeficiency virus type 1 consists of a noncovalently linked dimer of two identical, unspliced RNA ...initiation site (DIS), and the type of interaction is ... See full document
10
Transcription factor binding sites downstream of the human immunodeficiency virus type 1 transcription start site are important for virus infectivity.
... oligonucleotide primer corresponding to nt 489 to 510 (59-AGCTCTCTG GCTAACTAGGGAAC-39) and a 39 primer corresponding to nt 793 to 814 ...nucleotide sequences of all five clones were identical and ... See full document
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Effects of the simian virus 40 origin of replication on transcription from the human immunodeficiency virus type 1 promoter.
... induced replication or some closely related characteristic of T-antigen binding imparts positive effects on LTR-directed gene ...the replication function of the origin abrogated the ... See full document
6
Simple enzyme immunoassay for titration of antibodies to the CD4 binding site of human immunodeficiency virus type 1 gp120
... V3 sequences have already been developed ...CD4 binding to gp120 (1) or by an immu- noassay with specific antibody binding to conformational epi- ...several human MAbs derived from ... See full document
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Role of CD4 epitopes outside the gp120-binding site during entry of human immunodeficiency virus type 1.
... inhibited replication of HIV-1 and that this inhibition occurred at a step after virus ...inhibit virus replication and syncytium formation ...inhibit virus entry and syncytium ... See full document
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