[PDF] Top 20 Efficient Herpes Simplex Virus 1 Replication Requires Cellular ATR Pathway Proteins

... which ATR signaling could be ...with ATR path- way ...the virus-encoded exonuclease UL12 has recently been shown to interact with cellular repair machinery and to stimulate recombination by a ... See full document

... this pathway are deleterious to viral replication. Multiple ATR and Chk1 inhibitors show potent antiviral effects against HSV-1, exceeding 10-fold reductions in infectious virus ... See full document

... 2011 Herpes simplex virus 1 (HSV-1) is a double-stranded DNA virus that replicates in the nucleus of its human host cell and is known to interact with many cellular DNA ... See full document

... in herpes simplex virus 1-infected cells, ICP22 upregulates the accumulation of a subset of ␥ 2 proteins exemplified by the products of the U L 38, U L 41, and U S 11 ...dependent ... See full document

... the herpes simplex virus type 1 (HSV-1) genome might be expected to induce a DNA damage response, the ATR kinase is not activated in infected ...of ATR from its ... See full document

... Biology 1 and Department of Microbiology and Immunology, 2 University of North Carolina School of Medicine, Chapel Hill, North Carolina Received 10 May 2004/Accepted 28 July 2004 Infection by herpes ... See full document

... the herpes simplex virus (HSV) protein ICP0 has cytoplasmic roles in blocking antiviral sig- naling and in promoting viral replication in addition to its well-known proteasome-dependent ... See full document

... 50 cellular and viral proteins that are associated with the herpes simplex virus 1 (HSV-1) ICP8 single-stranded DNA-binding ...coprecipitating cellular ... See full document

... Herpes simplex virus 1 (HSV-1) mRNAs are exported to the cytoplasm through the export receptor TAP/ ...viral replication compartments, however, Aly/REF knockdown has little ... See full document

... Herpes simplex virus 1 (HSV-1) protein VP22, encoded by the UL49 gene, is a major virion tegument ...for efficient redistribution of viral proteins VP16, VP26, ICP0, ICP4, ... See full document

... The results of our experiments using cycloheximide and HSV-1 mutants demonstrate that the early delocalization of nucleolin from the nucleolus is not the consequence of the release of viral proteins from ... See full document

... and cellular factors that allows HSV-1 to enter host cells and establish ...for cellular cholesterol in the entry of HSV-1 into target ... See full document

... these proteins are related only by their modification by SUMO-1, we suggest that degradation occurs via a common pathway rather than by specific targeting of the individual susceptible ...homologue ... See full document

... the cellular response to a broad range of stress factors through its ability to regulate various cellular ...expressed herpes simplex virus 1 (HSV-1) regulatory protein ... See full document

... Membranes prepared from HEp-2 cells infected with herpes simplex virus and.. free from soluble proteins, virus, ribosomes, and other cellular constituents were.[r] ... See full document

... 1998/Accepted 1 April 1998 Several observations indicate that late-G 1 /S-phase-specific cellular functions may be required for herpes simplex virus (HSV) replication: (i) ... See full document

... Abstract Herpes simplex virus - 1 (HSV-1) is a common human double-stranded DNA virus that can cause a variety of pathologies, including recurrent oral lesions in the ... See full document

... The herpes simplex virus type 1 (HSV-1) origin of DNA replication, oriS, contains three binding sites for the viral origin binding protein (OBP) flanked by transcriptional ... See full document

... Of the HSV-1 gene sequences that contained potential homologs to the VP5 LBS (Table 2), good competition was observed by using excess unlabeled promoter fragments from the VP5 and glycop[r] ... See full document

... to replication of a virus or viral ...oncolytic virus, reduced replication capability would be expected to be directly reflected in lower oncolytic ...wild-type virus and an attenuated ... See full document